Results 111 to 120 of about 11,372 (280)

Isolation, identification and characterization of potential impurities of anidulafungin [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2017
Eight impurities ranging from 0.03 to 0.97% in anidulafungin bulk drug were detected by HPLC. Four impurities (Imp-I, Imp-II, Imp-III and Imp-VIII) among impurities were isolated from the self-prepared or marketed samples of anidulafungin bulk drug by means of preparative HPLC.
Lanning Zhao, Qilong Wang, Yi Bie, Xiaoxia Lu   +3 more
openaire   +3 more sources

Fungal infections of the central nervous system: A review of fungal pathogens and treatment [PDF]

, 2007
Multiple factors influence the outcome of fungal infection of the central nervous system (CNS). The host and the pathogen in concert with drug delivery across the blood-brain barrier and drug activity are key factors in outcome.
Dancer, C., Redmond, A., Woods, M. L.
core   +1 more source

Comparison of the Equivalence of Aspergillus Antigen and PCR Results Between Non‐Directed Bronchial Lavage and Bronchoalveolar Lavage—A Prospective Exploratory Pilot Study in Critically Ill Patients

Mycoses, Volume 68, Issue 2, February 2025.
ABSTRACT Background Obtaining non‐directed samples from the upper bronchial tree is easier to perform and poses fewer risks for critically ill patients than deep bronchoalveolar lavage (BAL). Since invasive pulmonary aspergillosis is associated with a high mortality in critically ill patients, timely diagnosis and rapid initiation of treatment are of ...
Maria Schroeder, Mohamad Abd Raboh, Annika Nuechtern, Dominic Wichmann, Johannes Stamm, Tim Hardel, Holger Rohde, Martin Christner, Ann‐Kathrin Ozga, Stefan Steurer, Claudia Jafari, Hans Klose, Stefan Kluge, Marcel Simon, Marlene Fischer   +14 more
wiley   +1 more source

Criteria for the administration of systemic antimicotic therapy in surgical intensive care units (literature review)

Тазовая хирургия и онкология, 2019
This review focuses on the practical aspects of prevention and treatment of fungal infections in surgical patients. It covers epidemiology and risk factors for invasive candidiasis, updates on the etiological structure of fungal infections in patients in
B. Z. Belotserkovskiy, E. B. Gelfand, A. O. Bykov, O. A. Mamontova, D. N. Protsenko   +4 more
doaj   +1 more source

Susceptibility of the Candida haemulonii Complex to Echinocandins: Focus on Both Planktonic and Biofilm Life Styles and a Literature Review

Journal of Fungi, 2020
Candida haemulonii complex (C. haemulonii, C. duobushaemulonii and C. haemulonii var. vulnera) is well-known for its resistance profile to different available antifungal drugs.
Lívia S. Ramos, Laura N. Silva, Marta H. Branquinha, André L. S. Santos   +3 more
doaj   +1 more source

Anidulafungin dosing during CRRT: do not underestimate adsorption! [PDF]

Critical Care, 2014
Two recent papers in Critical Care discuss the use of echinocandins in general [1], and anidulafungin in particular [2], during continuous renal replacement therapy (CRRT). Being highly protein bound and predominantly nonrenally eliminated drugs, echinocandins are barely removed by convection and thus require no dose adjustment during CRRT. Based on
Honoré, Patrick M, Jacobs, Rita, De Waele, Elisabeth, Spapen, Herbert D   +3 more
openaire   +4 more sources

Enhancing Flucytosine Anticandidal Activity Using PEGylated Squalene Nanocarrier

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
Our study focused on improving the effectiveness of the antifungal drug 5‐fluorocytosine (5FC) by loading it in micellar structures formed by PEGylated squalene copolymer. The obtained results for 5FC‐loaded micelles showed in vitro prolonged release under physiological conditions and improved in vitro antifungal activity without cytotoxicity for ...
Bogdan‐Florin Craciun, Irina Rosca, Dragos Peptanariu, Mariana Pinteala   +3 more
wiley   +1 more source

Evaluation of anidulafungin in the treatment of intra-abdominal candidiasis: a pooled analysis of patient-level data from 5 prospective studies

European Journal of Clinical Microbiology and Infectious Diseases, 2019
The incidence of nosocomial invasive fungal infections involving Candida spp. has increased markedly in recent years in patients undergoing abdominal surgery. This post hoc analysis aimed to determine the efficacy and safety of anidulafungin treatment in
G. Sganga, Minggui Wang, M. Capparella, M. Tawadrous, J. Yan, J. Aram, P. Montravers   +6 more
semanticscholar   +1 more source

FDA‐approved drugs featuring macrocycles or medium‐sized rings

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
This review presents 17 macrocyclic drugs approved by the U.S. Food and Drug Administration during the past 5 years, highlighting their importance and critical role in modern therapeutics, and the innovative synthetic approaches for the construction of these macrocycles.
Youlong Du, Anas Semghouli, Qian Wang, Haibo Mei, Loránd Kiss, Daniel Baecker, Vadim A. Soloshonok, Jianlin Han   +7 more
wiley   +1 more source

Anidulafungin compared with fluconazole for treatment of candidemia and other forms of invasive candidiasis caused by Candida albicans: a multivariate analysis of factors associated with improved outcome

BMC Infectious Diseases, 2011
Background Candida albicans is the most common cause of candidemia and other forms of invasive candidiasis. Systemic infections due to C. albicans exhibit good susceptibility to fluconazole and echinocandins.
Reisman Arlene L, Schlamm Haran T, Kett Daniel H, Pappas Peter G, Rotstein Coleman, Shorr Andrew F, Reboli Annette C, Biswas Pinaki, Walsh Thomas J   +8 more
doaj   +1 more source