Challenges facing the elimination of sleeping sickness in west and central Africa: sustainable control of animal trypanosomiasis as an indispensable approach to achieve the goal [PDF]
Parasites & Vectors, 2015 African trypanosomiases are infectious diseases caused by trypanosomes. African animal trypanosomiasis (AAT) remains an important threat for livestock production in some affected areas whereas human African trypanosomiasis (HAT) is targeted for ...
Gustave Simo, Jean Baptiste Rayaisse
doaj +2 more sources
Bovine and small ruminant African animal trypanosomiasis in Nigeria – A review
Veterinary Parasitology: Regional Studies and Reports, 2018 Despite extensive attempts over many decades to control African Animal Trypanosomiasis (AAT) across the tsetse fly belt of Nigeria, AAT persists as major animal health problem causing severe morbidity and mortality in livestock. The large agricultural losses in turn have severe adverse impacts on sustainable agricultural development.
Paul Olalekan Odeniran +3 more
openalex +7 more sources
Combatting African Animal Trypanosomiasis (AAT) in livestock: The potential role of trypanotolerance [PDF]
Veterinary Parasitology, 2016 African Animal Trypanosomiasis (AAT) is endemic in at least 37 of the 54 countries in Africa. It is estimated to cause direct and indirect losses to the livestock production industry in excess of US$ 4.5 billion per annum. A century of intervention has yielded limited success, owing largely to the extraordinary complexity of the host-parasite ...
Mohammed Yaro +3 more
openalex +6 more sources
Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model [PDF]
Journal of Medicinal Chemistry, 2019 Animal African trypanosomiasis (AAT) is a significant socioeconomic burden for sub-Saharan Africa because of its huge impact on livestock health. Existing therapies including those based on minor groove binders (MGBs), such as the diamidines, which have been used for decades, have now lost efficacy in some places because of the emergence of resistant ...
Federica Giordani +7 more
openalex +7 more sources
Animal African Trypanosomiasis: Time to Increase Focus on Clinically Relevant Parasite and Host Species [PDF]
Trends in Parasitology, 2016 Animal African trypanosomiasis (AAT), caused by Trypanosoma congolense and Trypanosoma vivax, remains one of the most important livestock diseases in sub-Saharan Africa, particularly affecting cattle. Despite this, our detailed knowledge largely stems from the human pathogen Trypanosoma brucei and mouse experimental models.
Liam J. Morrison +3 more
openalex +6 more sources
A meta-analysis of the prevalence of African animal trypanosomiasis in Nigeria from 1960 to 2017 [PDF]
Parasites & Vectors, 2018 African animal trypanosomiasis is an economically significant disease that affects the livestock industry in Nigeria. It is caused by several parasites of the genus Trypanosoma. National estimates of the disease prevalence in livestock and tsetse flies are lacking, therefore a systematic review and meta-analysis were performed to understand the trend ...
Paul Olalekan Odeniran +1 more
openalex +5 more sources
Modelling to infer the role of animals in gambiense human African trypanosomiasis transmission and elimination in the DRC [PDF]
PLOS Neglected Tropical Diseases, 2022 Gambiense human African trypanosomiasis (gHAT) has been targeted for elimination of transmission (EoT) to humans by 2030. Whilst this ambitious goal is rapidly approaching, there remain fundamental questions about the presence of non-human animal transmission cycles and their potential role in slowing progress towards, or even preventing, EoT.
R. E. Crump +6 more
openalex +6 more sources
The role of domestic animals in the epidemiology of human african trypanosomiasis in Ngorongoro conservation area, Tanzania [PDF]
Parasites & Vectors, 2015 Trypanosomiasis is a neglected tropical disease caused by the trypanosome parasite and transmitted by the tsetse fly vector. In Sub-saharan Africa, both the human and animal variants of the disease are a great obstacle towards agriculture, development, and health.
Juan Pablo Ruíz +3 more
openalex +5 more sources
Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis [PDF]
, 2011 Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is ...
AA Poltera +45 more
core +66 more sources
Spatial distribution of African Animal Trypanosomiasis in Suba and Teso districts in Western Kenya [PDF]
BMC Research Notes, 2010 Los estudios sobre la epidemiología de la tripanosomiasis animal africana (AAT) rara vez consideran la dimensión espacial de la prevalencia de la enfermedad. Este problema se confunde con el uso de métodos de diagnóstico parasitológicos de baja sensibilidad en estudios de campo.
Samuel M. Thumbi +3 more
openalex +7 more sources