Results 71 to 80 of about 14,780 (225)

In Vitro and In Vivo Trypanocidal Efficacy of Synthesized Nitrofurantoin Analogs

Molecules, 2021
African trypanosomes cause diseases in humans and livestock. Human African trypanosomiasis is caused by Trypanosoma brucei rhodesiense and T. b. gambiense.
Linous Munsimbwe, Anna Seetsi, Boniface Namangala, David D. N’Da, Noboru Inoue, Keisuke Suganuma   +5 more
doaj   +1 more source

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II). [PDF]

, 2005
BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule.
Asumu, P, Bilenge, C M M, Burri, C, Chappuis, F, Doua, F, Josenando, T, Manthelot, C R, Nangouma, A, Richer, M, Schmid, C, Simarro, P   +10 more
core   +2 more sources

A review on the diagnosis of animal trypanosomoses

Parasites & Vectors, 2022
This review focuses on the most reliable and up-to-date methods for diagnosing trypanosomoses, a group of diseases of wild and domestic mammals, caused by trypanosomes, parasitic zooflagellate protozoans mainly transmitted by insects.
Marc Desquesnes, Marisa Gonzatti, Alireza Sazmand, Sophie Thévenon, Géraldine Bossard, Alain Boulangé, Geoffrey Gimonneau, Philippe Truc, Stéphane Herder, Sophie Ravel, Denis Sereno, Vincent Jamonneau, Sathaporn Jittapalapong, Philippe Jacquiet, Philippe Solano, David Berthier   +15 more
doaj   +1 more source

Bioactivity profiles of progressively ring‐fluorinated cyclohexyl motifs in the WKYMVm peptide as formylpeptide FPR2 agonists and in keto‐piperazines as anti‐trypanosome agents.

ChemBioChem, Accepted Article.
A series of all‐cis ring fluorinated cyclohexylalanines with progressively increasing levels of vicinal fluorines, as well as 4‐fluorophenylalanine and pentafluoroarylphenylalanine were introduced into the WKYMVm peptide in place of its tyrosine residue, for assays against the G‐protein coupled formylpeptide receptor, FPR2.
David O'Hagan, Mengfan He, Christina M Thomson, Dawn Thompson, Vytautus Kuodis, Terence K. Smith, Sergio Dall'Angelo   +6 more
wiley   +1 more source

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic Forms

mSphere, 2022
Trypanosoma brucei, the causative agent of human and animal African trypanosomiasis, cycles between a mammalian host and a tsetse fly vector. The parasite undergoes huge changes in morphology and metabolism during adaptation to each host environment ...
Ethan Ashby, Lucinda Paddock, Hannah L. Betts, Jingwen Liao, Geneva Miller, Anya Porter, Lindsey M. Rollosson, Carrie Saada, Eric Tang, Serenity J. Wade, Johanna Hardin, Danae Schulz   +11 more
doaj   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, EarlyView.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Counterflow dielectrophoresis for trypanosome enrichment and detection in blood [PDF]

, 2012
Human African trypanosomiasis or sleeping sickness is a deadly disease endemic in sub-Saharan Africa, caused by single-celled protozoan parasites. Although it has been targeted for elimination by 2020, this will only be realized if diagnosis can be ...
A Carlsson, F Chappuis, FH Labeed, J Vykoukal, JA Rodriguez, KS Ralston, M Jacob, M Murray, MP Barrett, NG Green, P Gascoyne, SC Welburn, SH Holm, U Kim, WH Lumsden, WT Freeman, X-B Wang, XB Wang, Y Huang, ZK Njiru   +19 more
core   +1 more source

Effect of Spiroplasma infection on the mating behavior of Glossina fuscipes fuscipes

Insect Science, EarlyView.
Abstract Tsetse flies are insects of significant public health and zoonotic importance as they are the main vectors of African trypanosomes. To date, an effective vaccine is unavailable and efforts to limit the spread of the disease primarily rely on controlling the tsetse populations.
Giulia Fiorenza, Riccardo Piccinno, Daniel J. Bruzzese, Francesca Scolari, Gloria Milanesi, Claudio Casali, Ludvik M. Gomulski, Francesco Lescai, Federico Forneris, Giuliano Gasperi, Kiswend‐sida M. Dera, Chantel de Beer, Adly M.M. Abd‐Alla, Serap Aksoy, Anna R. Malacrida   +14 more
wiley   +1 more source

Prevalence of trypanosomes associated with drug resistance in Shimba Hills, Kwale County, Kenya

BMC Research Notes, 2020
Objective Animal African trypanosomiasis (AAT) is a life-threatening vector-borne disease, caused by trypanosome parasites, which are principally transmitted by tsetse flies.
Benard W. Kulohoma, Sarah A. O. Wamwenje, Ibrahim I. Wangwe, Nicodemus Masila, Caroline K. Mirieri, Lillian Wambua   +5 more
doaj   +1 more source

Wing Interferential Patterns (WIPs) and machine learning, a step toward automatized tsetse (Glossina spp.) identification

Scientific Reports, 2022
A simple method for accurately identifying Glossina spp in the field is a challenge to sustain the future elimination of Human African Trypanosomiasis (HAT) as a public health scourge, as well as for the sustainable management of African Animal ...
Arnaud Cannet, Camille Simon-Chane, Mohammad Akhoundi, Aymeric Histace, Olivier Romain, Marc Souchaud, Pierre Jacob, Pascal Delaunay, Darian Sereno, Philippe Bousses, Pascal Grebaut, Anne Geiger, Chantel de Beer, Dramane Kaba, Denis Sereno   +14 more
doaj   +1 more source