Results 51 to 60 of about 553,501 (299)

Functions of the Microbiota for the Physiology of Animal Metaorganisms [PDF]

Journal of Innate Immunity, 2018
Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner fulfils its versatile and crucial role.
Daniela Esser, Janina Lange, Georgios Marinos, Michael Sieber, Lena Best, Daniela Prasse, Jay Bathia, Malte C. Rühlemann, Kathrin Boersch, Cornelia Jaspers, Felix Sommer   +10 more
openaire   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Probing subicular inputs to the medial prefrontal cortex

iScience, 2021
Summary: The hippocampal formation is anatomically and functionally divided into a dorsal and a ventral part, being involved in processing cognitive tasks and emotional stimuli, respectively.
Sanne Beerens, Rozan Vroman, Jack F. Webster, Christian Wozny   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hydra as an animal model system in Physiology [PDF]

, 2021
Hydra has been used as a model in different topics in biology, including physiology. It pertains to the Phylum Cnidaria, an ancestral group of Metazoa that shares a common ancestor with Bilateria.
Gavazzi, Maria Victoria, Alzugaray, Maria Eugenia, Ronderos, Jorge Rafael   +2 more
core  

The Animal-Human Interface in Farm Animal Production: Animal Fear, Stress, Reproduction and Welfare

, 2022
A negative human-animal relationship (HAR) from the perspective of the animal is a limiting factor affecting farm animal welfare, as well as farm animal productivity.
Rutu Y. Acharya, Hemsworth, PH, Coleman, GJ, Paul H. Hemsworth, Grahame J. Coleman, Acharya, RY, James E. Kinder, Kinder, JE   +7 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Developing and validating the ACCA (Activation-Collaboration-Creation-Application) learning model to enhance students’ collaboration

Research and Development in Education
Collaboration skills are crucial for students to engage in teamwork, solve problems collectively, and construct deeper understanding through interactive discussions.
Andi Muharni, Susriyati Mahanal, Siti Zubaidah, Hendra Susanto, H. Hardianto   +4 more
doaj   +1 more source