Results 91 to 100 of about 321,984 (308)
Development of MicroRNA Therapeutics for Hepatocellular Carcinoma
Diagnostics, 2013 Hepatocellular carcinoma (HCC) is the most common form of liver cancer and is the third leading cause of cancer-related deaths worldwide. Treatment options for HCC are very limited, as it is often diagnosed at a late stage.
Rajagopal N. Aravalli
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
TAX REFORM AND BEEF COW REPLACEMENT STRATEGY [PDF]
This paper models optimal beef cow replacement strategy in a stochastic environment under U.S. income tax rules effective before and after the Tax Reform Act of 1986. Under each tax regime, the producer's buy versus raise decision and optimal culling age
Carman, Hoy F., Innes, Robert
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
NUTRITION AND THE ECONOMICS OF SWINE MANAGEMENT [PDF]
Current methods of formulating animal rations lead to excess nutrient excretion which can potentially lead to excess manure nutrients and an increase in economic costs. These methods do not recognize the impact of diminishing returns. The objective is to
Boland, Michael A. +2 more
core +1 more source
Dynamic programming applied to animal replacement decisions [PDF]
, 1975 This study of the economics of animal replacement lies on the border of two well developed areas of knowledge. On the one hand it draws on the theory of animal breeding and on the other on replacement theory.
McArthur, A. T. G.
core
Journal of Animal Law, Ethics and One HealthThe 3R principles (Replacement, Reduction, Refinement) have become a widely used regulatory framework for governing animal research worldwide. While widely endorsed as a moral baseline, its actual capacity to protect animals and to support a transition ...
Rosa Maria Cajiga +5 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The Role of the Three Rs in Improving the Planning and Reproducibility of Animal Experiments [PDF]
, 2019 Efforts to improve the design of animal studies have tended to focus on the more mathematical aspects, such as randomization, blocking and statistical analysis. There are, however, many other factors that affect the data from preclinical studies.
Adrian J. Smith +3 more
core +1 more source
[Corrigendum] Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer. [PDF]
Oncol Rep, 2023 Bauer N +3 more
europepmc +1 more source