Results 11 to 20 of about 754,514 (306)

Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays

Toxins, 2020
Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs).
Maren Schenke, Brit-Maren Schjeide, Gerhard P. Püschel, Bettina Seeger   +3 more
doaj   +1 more source

Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue. [PDF]

, 2020
Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications.
Binette, Francois, Glickman, Randolph D, Nasonkin, Igor O, Petersen-Jones, Simon M, Seiler, Magdalene, Singh, Ratnesh K, Winkler, Paige   +6 more
core   +1 more source

Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells

Frontiers in Public Health, 2018
There is increased interest in using high throughput in vitro assays to characterize human population variability in response to toxicants and drugs. Utilizing primary human endothelial colony-forming cells (ECFCs) isolated from blood would be highly ...
Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J. Van Kanegan, John W. Ludlow, Dora Il'yasova, Alexander Kinev   +7 more
doaj   +1 more source

Effect of preoperative thoracic duct drainage on canine kidney transplantation [PDF]

, 1996
Chronic drainage of the thoracic duct to the esophagus was developed in dogs, and its efficacy in immunomodulation was tested using kidney transplantation. Compared to 9.7 days in the control, the mean animal survival was prolonged to 9.9 days, 17.8 days,
Archimbaud JP, Atsuhito Yagihashi, Depster WJ, Dumont AE, Fischer DC, Franksson C, Franksson C, Giuseppe Carrieri, Gowans JL, Harvey J, Janossy G, Johnson HK, Julius MH, Kawai T, Koep LJ, Kohler G, Krawiec DR, Lemke H, Machieder HI, McGregor DD, McKneally M, Medawar PB, Meeker W, Mukenzie JL, Murray JE, Mysliwietz JJ, Newton WT, Oh CY, Prendergast MM, Sales HE, Satoru Todo, Schwartz R, Shibata Y, Starzl TE, Starzl TE, Starzl TE, Thomas E. Starzl, Traeger J, Williamson E PM, Woodruff M FA, Wulff JC, Wulff JC, Yoichi Funakoshi, Yuichi Iwaki   +43 more
core   +1 more source

Survey of Canadian animal-based researchers' views on the Three Rs: replacement, reduction and refinement. [PDF]

PLoS ONE, 2011
The 'Three Rs' tenet (replacement, reduction, refinement) is a widely accepted cornerstone of Canadian and international policies on animal-based science.
Nicole Fenwick, Peter Danielson, Gilly Griffin   +2 more
doaj   +1 more source

EURL ECVAM Status Report on the Development, Validation and Regulatory Acceptance of Alternative Methods and Approaches (2016) [PDF]

, 2016
Replacement, Reduction and Refinement of animal testing is anchored in EU legislation. Alternative non-animal approaches facilitate a shift away from animal testing.
ASTURIOL BOFILL DAVID, BELZ SUSANNE, BERGGREN ELISABET, BERNASCONI Camilla, BOPP Stephanie, BOSTROEM Ann-Charlotte, BOUHIFD Mounir, CASATI Silvia, COECKE Sandra, COLE Thomas, CORVI Raffaella, HALDER MARIA ELISABETH, HOLLEY TRACEY, HORVAT TOMISLAV, JANUSCH ROI Annett, KIENZLER AUDE, LANDESMANN Brigitte, MADIA FEDERICA, MILCAMPS Anne, MUNN SHARON, PAINI ALICIA, PALOSAARI Taina, PRICE Anna, PRIETO PERAITA Maria Del Pilar, RICHARZ ANDREA, TRIEBE Jutta, VIEGAS BARROSO JOAO FILIPE, WHELAN Maurice, WITTWEHR Clemens, WORTH Andrew, ZUANG Valerie   +30 more
core   +1 more source

Researchers' attitudes to the 3Rs-An upturned hierarchy? [PDF]

PLoS ONE, 2018
Animal use in biomedical research is generally justified by its potential benefits to the health of humans, or other animals, or the environment. However, ethical acceptability also requires scientists to limit harm to animals in their research. Training
Nuno Henrique Franco, Peter Sandøe, I Anna S Olsson   +2 more
doaj   +1 more source

HE WAYS OF INCREASING THE BIOAVAILABILITY OF LEGUMES IN THE TECHNOLOGY OF FAST-PREPARATION FOOD CONCENTRATES

Современная наука и инновации, 2022
Globally, the replacement of animal protein with more available plant proteins in food is relevant from the point of view of a more sustainable food supply.
S. A. Urubkov, A. A. Korolev, S. O. Smirnov   +2 more
doaj   +1 more source

Variação da pressão sistólica como indicadora precoce de hipovolemia e guia de reposição volêmica com solução hiperosmótica e hiperoncótica no cão Variación de la presión sistólica como indicadora precoz de hipovolemia y guía de reposición volemica con solución hiperosmótica e hiperoncótica en el perro Systolic pressure variation as an earlier hypovolemia indicator and a guide for volume replacement with hypertonic and hyperoncotic solution in dogs

Revista Brasileira de Anestesiologia, 2003
JUSTIFICATIVA E OBJETIVOS: Estudos introduziram novo método para avaliação da pré-carga, baseado na análise da variação da pressão sistólica (VPS) durante ventilação artificial.
Odilar de Paiva Filho, José Reinaldo Cerqueira Braz, Fredson de Paula e Silva, Tiago Otávio Pedro, Paulo do Nascimento Júnior   +4 more
doaj   +1 more source

Searching and review on the Three Rs information in Korea: time for quality assessment and continued education [PDF]

BMB Reports, 2013
Scientists planning research that involves the use of animals arerequired by international and/or national law to examine thepossibilities for the implementation of Replacement, Reductionand/or Refinement (the Three Rs principles of Russell and Burch)in ...
Gwi Hyang Lee, Byung In Choe
doaj   +1 more source