Results 41 to 50 of about 321,984 (308)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Human cardiomyocytes for drug discovery
Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018 Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi +14 more
doaj +7 more sources
Replacing animals in biomedical research [PDF]
Nature, 1978 Alternatives to Animal Experiments. By D. H. Smyth. Pp. 216. (Scolar Press: London, 1978.) Hardback £6; paperback £2.90.
openaire +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Applied Sciences, 2021 Fishmeal is the main source of dietary protein for most commercially farmed fish species. However, fishmeal prices have been raised even further because of competition with domestic animals, shortage in world fishmeal supply, and increased demand ...
Rendani Luthada-Raswiswi +2 more
doaj +1 more source
Husbandry of Dairy Animals | Goat: Replacement Management
, 2011 Raising replacement dairy kids begins with prenatal care of the doe. The doe needs to be properly vaccinated before kidding, be in proper body condition, and have good nutrition, including vitamins and minerals. A program to prevent caprine arthritis encephalitis must be instituted, which involves removal of the kid from the doe at birth, feeding heat ...
Hart, S., Delaney, C.
openaire +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Dr Hadwen Trust for humane research: 39 years of replacement science [PDF]
, 2009 The year 2009 will not be remembered mainly because it is the Chinese year of the ox, but probably, for many, because it is Charles Darwin’s bicentenary, the 150th anniversary of the publication of his masterpiece, The Origin of Species, the 50th ...
Farnaud, S.
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Exigência proteica e ingrediente alternativo em dietas para juvenis de cachara, Pseudoplatystoma reticulatum [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aquicultura, Florianópolis, 2013.Foi avaliada a exigência proteica e a utilização da farinha de vísceras de frango (FV) como ingrediente ...
Cornélio, Fernando Henrique Gomes
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