Results 31 to 40 of about 321,984 (308)

Alternative in vitro and in silico models to reduce animal use: a crucial technological advance in dermatological sciences

Expert Reviews in Molecular Medicine
Introduction Alternative models are tools to replace and reduce the number of animals used in biomedical sciences, for either research or tests of industrial products. Several new alternative models have been developed in the most diverse fields.
Carla Zanatelli, Luiza Pretto, Thaís Casagrande Paim, Márcia Rosângela Wink   +3 more
doaj   +1 more source

A brief history of the animals’ scientific research, international rules and Brazilian regulations [PDF]

Anais da Academia Brasileira de Ciências
Several countries and non-governmental organizations have discussed the use of animals in industry and biomedical areas. This work shows the progression of animal’ rights for scientific purposes in Brazil and how Brazilian Councils have advanced to ...
CARLA LORENA S. RAMOS, JOSÉ IVO A. BESERRA FILHO, DIEGO P. DE MENEZES, PAULO MICHEL P. FERREIRA   +3 more
doaj   +1 more source

The Promise of Behavioral Tracking Systems for Advancing Primate Animal Welfare [PDF]

, 2022
SIMPLE SUMMARY: Computerized tracking systems for primates and other animals are one of the great inventions of the 21st century. These systems have already revolutionized the study of primatology, psychology, neuroscience, and biomedicine.
Jan Zimmermann, Knaebe, Brenna, Weiss, Claudia C., Benjamin Y. Hayden, Zimmermann, Jan, Claudia C. Weiss, Brenna Knaebe, Hayden, Benjamin Y.   +7 more
core   +1 more source

Replacement of Animal Fat by Canola Oil in Chicken Meatball [PDF]

Brazilian Journal of Poultry Science
This work aimed to develop chicken meatballs with five levels of animal fat replacement by canola oil and to evaluate the product’s behavior during 120 days of storage.
ASP Vieira, XR Souza, EC Rodrigues, DC Sousa   +3 more
doaj   +2 more sources

Animal Welfare Ethics in Research and Testing: Implementation and its Barrier [PDF]

, 2020
Animals have an important role in research and testing to improve human and animal health. Animal usage must be balanced between science and ethical values of animal welfare.
Wahyuwardani, Sutiastuti, Noor, S M, Bakrie, B   +2 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Non-animal-based options for animal-based foods- towards a systematic terminology

Frontiers in Nutrition, 2023
The market has seen a rapid increase in animal-free products intended to replace animal-based foods due to concerns for human health and environmental sustainability.
Nazanin Abbaspour, Ruben Sanchez-Sabate, Ruben Sanchez-Sabate, Joan Sabaté   +3 more
doaj   +1 more source