Results 11 to 20 of about 311,505 (261)

Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays

Toxins, 2020
Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs).
Maren Schenke, Brit-Maren Schjeide, Gerhard P. Püschel, Bettina Seeger   +3 more
doaj   +1 more source

Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells

Frontiers in Public Health, 2018
There is increased interest in using high throughput in vitro assays to characterize human population variability in response to toxicants and drugs. Utilizing primary human endothelial colony-forming cells (ECFCs) isolated from blood would be highly ...
Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J. Van Kanegan, John W. Ludlow, Dora Il'yasova, Alexander Kinev   +7 more
doaj   +1 more source

Survey of Canadian animal-based researchers' views on the Three Rs: replacement, reduction and refinement. [PDF]

PLoS ONE, 2011
The 'Three Rs' tenet (replacement, reduction, refinement) is a widely accepted cornerstone of Canadian and international policies on animal-based science.
Nicole Fenwick, Peter Danielson, Gilly Griffin   +2 more
doaj   +1 more source

Researchers' attitudes to the 3Rs-An upturned hierarchy? [PDF]

PLoS ONE, 2018
Animal use in biomedical research is generally justified by its potential benefits to the health of humans, or other animals, or the environment. However, ethical acceptability also requires scientists to limit harm to animals in their research. Training
Nuno Henrique Franco, Peter Sandøe, I Anna S Olsson   +2 more
doaj   +1 more source

Replacing Animal Use in Education and Training [PDF]

Alternatives to Laboratory Animals, 2018
In the USA, the general public want the use of animals in medical training to cease, but, at least in Australia, some teachers want it to continue, even when effective non-animal alternatives are available.
openaire   +2 more sources

Variação da pressão sistólica como indicadora precoce de hipovolemia e guia de reposição volêmica com solução hiperosmótica e hiperoncótica no cão Variación de la presión sistólica como indicadora precoz de hipovolemia y guía de reposición volemica con solución hiperosmótica e hiperoncótica en el perro Systolic pressure variation as an earlier hypovolemia indicator and a guide for volume replacement with hypertonic and hyperoncotic solution in dogs

Revista Brasileira de Anestesiologia, 2003
JUSTIFICATIVA E OBJETIVOS: Estudos introduziram novo método para avaliação da pré-carga, baseado na análise da variação da pressão sistólica (VPS) durante ventilação artificial.
Odilar de Paiva Filho, José Reinaldo Cerqueira Braz, Fredson de Paula e Silva, Tiago Otávio Pedro, Paulo do Nascimento Júnior   +4 more
doaj   +1 more source

Searching and review on the Three Rs information in Korea: time for quality assessment and continued education [PDF]

BMB Reports, 2013
Scientists planning research that involves the use of animals arerequired by international and/or national law to examine thepossibilities for the implementation of Replacement, Reductionand/or Refinement (the Three Rs principles of Russell and Burch)in ...
Gwi Hyang Lee, Byung In Choe
doaj   +1 more source

HE WAYS OF INCREASING THE BIOAVAILABILITY OF LEGUMES IN THE TECHNOLOGY OF FAST-PREPARATION FOOD CONCENTRATES

Современная наука и инновации, 2022
Globally, the replacement of animal protein with more available plant proteins in food is relevant from the point of view of a more sustainable food supply.
S. A. Urubkov, A. A. Korolev, S. O. Smirnov   +2 more
doaj   +1 more source

Opportunities for the replacement of animals in the study of nausea and vomiting [PDF]

British Journal of Pharmacology, 2009
Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments. Developing novel anti‐emetics and identifying emetic liability in novel chemical entities rely on models that can recreate the complexity of these multi‐system reflexes. Animal models (especially the ferret and dog)
A M, Holmes, J A, Rudd, F D, Tattersall, Q, Aziz, P L R, Andrews   +4 more
openaire   +2 more sources

Investigation of physicochemical and sensory characteristics of low calorie sponge cake made from flaxseed mucilage and flaxseed flour

Scientific Reports, 2023
This research aimed to extract flaxseed mucilage (FM) and investigate its rheological properties (static and dynamic tests) compared with animal oil. In the next stage, the D-optimal design was applied to investigate the effect of FM (0–60%) and FF (0–30%
Fariba Ahmadinia, Forogh Mohtarami, Mohsen Esmaiili, Sajad Pirsa   +3 more
doaj   +1 more source