Results 11 to 20 of about 321,984 (308)

Alternative methods to animal experimentation in rabbit nutrition trials integrating the 3Rs principles [PDF]

World Rabbit Science
Animal studies are essential to nutrition research, particularly in investigating the effects of dietary changes on animal growth, reproduction, health and metabolism.
María Cambra-López, Javier García, Juan José Pascual, Nuria Nicodemus   +3 more
doaj   +3 more sources

Scientific and educational animal use [PDF]

, 2022
Few animal welfare issues are more controversial than scientific or educational animal use, partly because harms are sometimes deliberately inflicted on animals.
Knight, A
core   +1 more source

Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays

Toxins, 2020
Botulinum neurotoxins (BoNTs) are potent neurotoxins produced by bacteria, which inhibit neurotransmitter release, specifically in their physiological target known as motor neurons (MNs).
Maren Schenke, Brit-Maren Schjeide, Gerhard P. Püschel, Bettina Seeger   +3 more
doaj   +1 more source

Mealworm (Tenebrio molitor Larvae) as an Alternative Protein Source for Monogastric Animal : A Review [PDF]

, 2020
Simple Summary Tenebrio molitor (T. molitor) larvae, known as mealworm, have been considered a good protein source for monogastric animals. They have a high quantity and quality of protein content and amino acid profile. The inclusion of T.
Hong, Jinsu, Kim, Yoo Yong, Jinsu Hong, Taehee Han, Yoo Yong Kim, Han, Taehee   +5 more
core   +1 more source

Initial Assessment of Variability of Responses to Toxicants in Donor-Specific Endothelial Colony Forming Cells

Frontiers in Public Health, 2018
There is increased interest in using high throughput in vitro assays to characterize human population variability in response to toxicants and drugs. Utilizing primary human endothelial colony-forming cells (ECFCs) isolated from blood would be highly ...
Daria Filonov, Raymond Tice, Ruiyan Luo, Chad Grotegut, Michael J. Van Kanegan, John W. Ludlow, Dora Il'yasova, Alexander Kinev   +7 more
doaj   +1 more source

Fostering Animal Welfare and Advancing 3Rs Principles through the Establishment of a 3Rs Advisory Group [PDF]

, 2023
Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement of ...
Adeyemi O. Adedeji, Noel Dybdal, Becky Lee, Donna Lee, Aija Kusi, Jessica C. Graham, Lisa Wong   +6 more
core   +1 more source

Survey of Canadian animal-based researchers' views on the Three Rs: replacement, reduction and refinement. [PDF]

PLoS ONE, 2011
The 'Three Rs' tenet (replacement, reduction, refinement) is a widely accepted cornerstone of Canadian and international policies on animal-based science.
Nicole Fenwick, Peter Danielson, Gilly Griffin   +2 more
doaj   +1 more source

Leishmania Animal Models Used in Drug Discovery: A Systematic Review [PDF]

, 2023
Many different animal models are in use for drug development for leishmaniasis, but a universal model does not exist. There is a plethora of models, and this review assesses their design, quality, and limitations, including the attention paid to animal ...
Henk D. F. H. Schallig, Jacob van der Ende   +1 more
core   +1 more source

Replacing Animal Use in Education and Training [PDF]

Alternatives to Laboratory Animals, 2018
In the USA, the general public want the use of animals in medical training to cease, but, at least in Australia, some teachers want it to continue, even when effective non-animal alternatives are available.
openaire   +2 more sources

Variação da pressão sistólica como indicadora precoce de hipovolemia e guia de reposição volêmica com solução hiperosmótica e hiperoncótica no cão Variación de la presión sistólica como indicadora precoz de hipovolemia y guía de reposición volemica con solución hiperosmótica e hiperoncótica en el perro Systolic pressure variation as an earlier hypovolemia indicator and a guide for volume replacement with hypertonic and hyperoncotic solution in dogs

Revista Brasileira de Anestesiologia, 2003
JUSTIFICATIVA E OBJETIVOS: Estudos introduziram novo método para avaliação da pré-carga, baseado na análise da variação da pressão sistólica (VPS) durante ventilação artificial.
Odilar de Paiva Filho, José Reinaldo Cerqueira Braz, Fredson de Paula e Silva, Tiago Otávio Pedro, Paulo do Nascimento Júnior   +4 more
doaj   +1 more source