Results 91 to 100 of about 5,358,841 (304)

Alternative methods to animal experimentation in rabbit nutrition trials integrating the 3Rs principles

World Rabbit Science
Animal studies are essential to nutrition research, particularly in investigating the effects of dietary changes on animal growth, reproduction, health and metabolism.
María Cambra-López, Javier García, Juan José Pascual, Nuria Nicodemus   +3 more
doaj   +1 more source

Research involving animals [PDF]

Nature, 1995
C, Blakemore, K, Boyd, L, Ward
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Editorial: Looking at the Complete Picture: Tackling Broader Factors Important for Advancing the Validity of Preclinical Models in Disease

Frontiers in Behavioral Neuroscience, 2022
Tim Karl, Jess Nithianantharajah, Ulrike Weber-Stadlbauer, Ulrike Weber-Stadlbauer   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A New Decade of Veterinary Research: Societal Relevance, Global Collaboration, and Translational Medicine

Frontiers in Veterinary Science, 2015
Mary M Christopher
doaj   +1 more source

The development of laboratory animal science and animal care of legislation and the consummation [PDF]

, 2012
Laboratory animal science is the use of non-human animals in experiments to obtain new knowledge and new technologies in biomedical research and testing.
Shizhong, Zhou
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evaluation of animal welfare on organic dairy farms in Finland [PDF]

, 2000
The evaluation of animal welfare on organic dairy farms was carried out in connection with the first Finnish research study on animal healthcare and welfare in 1996 to 1998.
Roiha, Ulla
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source