Results 131 to 140 of about 5,358,841 (304)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Animal research [PDF]

Nature, 1995
A. W. Thomas, S. Hererra
openaire   +3 more sources

Building resilience in animal research: a two-year mixed methods survey of organizational support programs. [PDF]

Front Vet Sci
Young L, Thompson-Iritani S, Bellanca RU, Ferrara F, Bell K, Martin T, LaFollette MR.   +6 more
europepmc   +1 more source

Transfecting genes [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Drug tapering in animal research: current practices and challenges. [PDF]

Front Pharmacol
Zhang Y, Chen M, Jiang T, Fu Q, Ma R, Nie L, You Y, Gao S, Rong P.   +8 more
europepmc   +1 more source

Experiments with twin calves offer evidence that cytotoxic T cells can clear T. parva infections [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Developing more inclusive approaches to animal research and patient involvement. [PDF]

Med Health Care Philos
Azilagbetor DM, Davies G, Geneviève LD, Shaw DM, Elger BS.   +4 more
europepmc   +1 more source

Implementing the 3Rs in Laboratory Animal Research-From Theory to Practice. [PDF]

Animals (Basel), 2023
Azkona G.
europepmc   +1 more source