Results 271 to 280 of about 282,052 (348)

One Health Approaches to Ethical, Secure, and Sustainable Food Systems and Ecosystems: Plant-Based Diets and Livestock in the African Context. [PDF]

Foods
Hosseini E, Tsegay ZT, Smaoui S, Elfalleh W, Antoniadou M, Varzakas T, Caraher M.   +6 more
europepmc   +1 more source

Use of alternatives to animal testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA partners’ forum

José Tarazona, Ana Fernandez-Agudo, Ondřej Adamovský, Marta Baccaro, Natalie Burden, Bruno Campos, Björn Hidding, Karen Jenner, David John, Katia Lacasse, Adam Lillicrap, Delina Y. Lyon, Samuel K. Maynard, Amelie Ott, Véronique Poulsen, M.M.M. Rasenberg, Katrin Schütte, M. Sobanska, James R. Wheeler   +18 more
openalex   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

Precision Medicine and the FDA Modernization Act 2.0: Catalyzing Innovation in Cardiovascular Therapy. [PDF]

Circ Genom Precis Med
Fullenkamp DE, Wilsbacher LD, Tadros HJ, Arora P, Cappola TP.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Bioengineered Humanoid-on-Chip Platforms: Tools for Evaluating the Effects of Environmental Exposure on Human Physiological Barriers. [PDF]

Thorac Res Pract
Saglam-Metiner P, Goksel O, Goksel T, Yilmaz OH, Erdal E, Yesil-Celiktas O.   +5 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The many facets of sustainability in medicinal chemistry: our personal experience. [PDF]

RSC Med Chem
Martinengo B, Diamanti E, Uliassi E, Bolognesi ML.   +3 more
europepmc   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

<i>Klebsiella pneumoniae</i> Infections in Dogs: A One Health Review of Antimicrobial Resistance, Virulence Factors, Zoonotic Risk, and Emerging Alternatives. [PDF]

Microorganisms
Mihu ML, Nadăş GC, Bouari CM, Fiț NI, Răpuntean S.   +4 more
europepmc   +1 more source