Results 31 to 40 of about 923,548 (275)

Identifying Key Factors for Accelerating the Transition to Animal-Testing-Free Medical Science through Co-Creative, Interdisciplinary Learning between Students and Teachers

Animals, 2022
Simple Summary In 2021, the European Parliament called on the European Commission to create an action plan to phase out animal experiments in the European Union.
Fatima Zohra Abarkan, Anna M. A. Wijen, Rebecca M G van Eijden, Fréderique Struijs, Phoebe Dennis, M. Ritskes-Hoitinga, I. Visseren-Hamakers   +6 more
semanticscholar   +1 more source

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Frontiers in Cellular Neuroscience, 2020
Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development.
Xiali Zhong, Xiali Zhong, Georgina Harris, Lena Smirnova, Valentin Zufferey, Rita de Cássia da Silveira e Sá, Fabiele Baldino Russo, Patricia Cristina Baleeiro Beltrao Braga, Patricia Cristina Baleeiro Beltrao Braga, Megan Chesnut, Marie-Gabrielle Zurich, Helena T. Hogberg, Thomas Hartung, Thomas Hartung, David Pamies, David Pamies   +15 more
doaj   +1 more source

Upholding the EU's Commitment to ‘Animal Testing as a Last Resort' Under REACH Requires a Paradigm Shift in How We Assess Chemical Safety to Close the Gap Between Regulatory Testing and Modern Safety Science

Alternatives to laboratory animals : ATLA, 2021
Animal use for testing chemicals under REACH continues to increase, despite advances in non-animal safety science during the past 15 years. The application of modern science and technology, and the use of ‘next generation’ weight-of-evidence assessment ...
J. Fentem, I. Malcomber, G. Maxwell, C. Westmoreland   +3 more
semanticscholar   +1 more source

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response

Frontiers in Genetics, 2018
Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach
Alexandra Maertens, Vy Tran, Andre Kleensang, Thomas Hartung, Thomas Hartung, Thomas Hartung   +5 more
doaj   +1 more source

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Particle and Fibre Toxicology, 2019
Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Georgina Harris, David Pamies, Lisia Maria Gobbo dos Santos, José Mauro Granjeiro, Helena T. Hogberg, Thomas Hartung, Lena Smirnova   +8 more
doaj   +1 more source

Replacement Strategies for Animal Studies in Inhalation Testing

Sci, 2021
Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
doaj   +1 more source

Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods [PDF]

Genomics & Informatics, 2020
Finding publications that propose alternative methods to animal experiments is an important but time-consuming task since researchers need to perform various queries to literature databases and screen many articles to assess two important aspects: the ...
Mariana Neves
doaj   +1 more source

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

Frontiers in Microbiology, 2018
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions.
Celina Monteiro Abreu, Lucio Gama, Lucio Gama, Susanne Krasemann, Megan Chesnut, Shelly Odwin-Dacosta, Helena T. Hogberg, Thomas Hartung, Thomas Hartung, David Pamies   +9 more
doaj   +1 more source

RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies

Frontiers in Pharmacology, 2022
By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes ...
Mieke Van Mulders, Mieke Van Mulders, Nancy Liodo Missigba, Nancy Liodo Missigba, Birgit Mertens, Vera Rogiers   +5 more
doaj   +1 more source

Author Guide for Addressing Animal Methods Bias in Publishing

Advanced Science, 2023
There is growing recognition that animal methods bias, a preference for animal‐based methods where they are not necessary or where nonanimal‐based methods may already be suitable, can impact the likelihood or timeliness of a manuscript being accepted for
Catharine E. Krebs, Celean Camp, Helder Constantino, Lilas Courtot, Owen Kavanagh, Janine McCarthy, Melanie‐Jasmin Ort, Shaarika Sarasija, Emily R. Trunnell   +8 more
doaj   +1 more source