Results 31 to 40 of about 282,052 (348)

Does low-energy sweetener consumption affect energy intake and body weight? A systematic review, including meta-analyses, of the evidence from human and animal studies [PDF]

, 2015
By reducing energy density, low-energy sweeteners (LES) might be expected to reduce energy intake (EI) and body weight (BW). To assess the totality of the evidence testing the null hypothesis that LES exposure (versus sugars or unsweetened alternatives ...
de Graaf, C, Higgs, S, Hogenkamp, P S, Lluch, A, Mela, D J, Ness, A R, Penfold, C, Perry, R, Putz, P, Rogers, P J, Yeomans, M R   +10 more
core   +5 more sources

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source

Learning about a Moving Target in Resource Management: Optimal Bayesian Disease Control [PDF]

, 2017
Resource managers must often make difficult choices in the face of imperfectly observed and dynamically changing systems (e.g., livestock, fisheries, water, and invasive species).
Fackler, Paul L, MacLachlan, Matthew J, Springborn, Michael R   +2 more
core   +1 more source

Alternatives to animal testing: A review

Saudi Pharmaceutical Journal, 2015
The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern
Doke, Sonali K., Dhawale, Shashikant C.
openaire   +2 more sources

Casting a wide net: use of diverse model organisms to advance toxicology [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hahn, M. E., & Sadler, K. C. Casting a wide net: use of diverse model organisms to advance toxicology.
Hahn, Mark E., Sadler, Kirsten C.
core   +1 more source

EURL ECVAM Strategy to replace, reduce and refine the use of fish in aquatic toxicity and bioaccumulation testing [PDF]

, 2014
The assessment of aquatic toxicity and bioaccumulation are important components of the environmental hazard and risk assessment of all types of chemicals, and are therefore included in several pieces of European Union and international legislation.
HALDER MARIA ELISABETH, KIENZLER AUDE, WHELAN Maurice, WORTH Andrew   +3 more
core   +1 more source

Effect of sub-chronic exposure to cigarette smoke, electronic cigarette and waterpipe on human lung epithelial barrier function

BMC Pulmonary Medicine, 2020
Background Taking into consideration a recent surge of a lung injury condition associated with electronic cigarette use, we devised an in vitro model of sub-chronic exposure of human bronchial epithelial cells (HBECs) in air-liquid interface, to ...
Baishakhi Ghosh, Hermes Reyes-Caballero, Sevcan Gül Akgün-Ölmez, Kristine Nishida, Lakshmana Chandrala, Lena Smirnova, Shyam Biswal, Venkataramana K. Sidhaye   +7 more
doaj   +1 more source

Brain organoids and organoid intelligence from ethical, legal, and social points of view

Frontiers in Artificial Intelligence
Human brain organoids, aka cerebral organoids or earlier “mini-brains”, are 3D cellular models that recapitulate aspects of the developing human brain.
Thomas Hartung, Thomas Hartung, Itzy E. Morales Pantoja, Lena Smirnova   +3 more
doaj   +1 more source

First Organoid Intelligence (OI) workshop to form an OI community

Frontiers in Artificial Intelligence, 2023
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of power ...
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, David H. Gracias, David H. Gracias, David H. Gracias, David H. Gracias, David H. Gracias, Timothy D. Harris, Timothy D. Harris, Tzahi Cohen-Karni, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Alexander S. Szalay, Alexander S. Szalay, Fang Han, Donald J. Zack, Donald J. Zack, Donald J. Zack, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Daniel Tornero, Caroline Krall, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung, Thomas Hartung   +57 more
doaj   +1 more source

Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory

Communications Biology
Brain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova   +13 more
doaj   +1 more source