Results 51 to 60 of about 281,616 (305)

Organoid intelligence for developmental neurotoxicity testing

Frontiers in Cellular Neuroscience
The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence
Dowlette-Mary Alam El Din, Jeongwon Shin, Alexandra Lysinger, Matthew J. Roos, Erik C. Johnson, Timothy J. Shafer, Thomas Hartung, Thomas Hartung, Thomas Hartung, Lena Smirnova   +9 more
doaj   +1 more source

2001 Consultation of organic farming research priorities in the UK [PDF]

, 2001
The following reports a consultation of organic farming research priorities in the UK in 2001. The information was collated by Organic Centre Wales, Institute of Rural Studies, University of Wales, Aberystwyth on behalf of MAFF organic farming unit and
Lampkin, Nic, Padel, Susanne, Powell, Jane   +2 more
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment

Frontiers in Cellular and Infection Microbiology, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut, Laura S. Muñoz, Laura S. Muñoz, Georgina Harris, Dana Freeman, Lucio Gama, Lucio Gama, Carlos A. Pardo, Carlos A. Pardo, David Pamies, David Pamies   +10 more
doaj   +1 more source

Female and male Wistar rats (Rattus norvegicus) discriminate diets according to energetic quantity [PDF]

, 2020
The food choice of animals is influenced by several factors including the quantity and nutrients available. It is not known, however, whether faced with alternatives that present the same amount of food, with similar flavor and obtained with the same ...
Aragon, Davi Casadele, Pansarim, Vítor, Schmidt, Andreia, Warisaia, Vinícius, Zucoloto, Fernando Sergio   +4 more
core  

Behavioral conservatism is linked to complexity of behavior in chimpanzees (Pan troglodytes):implications for cognition and cumulative culture [PDF]

, 2018
Cumulative culture is rare, if not altogether absent in nonhuman species. At the foundation of cumulative learning is the ability to modify, relinquish, or build upon previous behaviors flexibly to make them more productive or efficient.
Davis, Sarah J., Lambeth, Susan P., Schapiro, Steven J., Whiten, Andrew, Wood, Lara A.   +4 more
core   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends

Metabolites
Metabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology and drug development.
Fenna Sillé, Thomas Hartung
doaj   +1 more source

Social Context Modulates Tolerance For Pragmatic Violations In Binary But Not Graded Judgments [PDF]

, 2019
A common method for investigating pragmatic processing and its development in children is to have participants make binary judgments of underinformative (UI) statements such as Some elephants are mammals.
Grodner, Daniel J., Kim, M., Sikos, L.
core   +4 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source