Results 51 to 60 of about 923,548 (275)

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

Frontiers in Toxicology
Biocompatibility testing ensures the safety of medical devices by assessing their compatibility with biological systems and their potential to cause harm or adverse reactions.
H. Kanďárová, P. Pôbiš
semanticscholar   +1 more source

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment

Frontiers in Cellular and Infection Microbiology, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut, Laura S. Muñoz, Laura S. Muñoz, Georgina Harris, Dana Freeman, Lucio Gama, Lucio Gama, Carlos A. Pardo, Carlos A. Pardo, David Pamies, David Pamies   +10 more
doaj   +1 more source

Effects of chronic browsing on life‐history traits of an irruptive large herbivore population

Population Ecology, EarlyView.
This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji, Kazutaka M. Takeshita, Hiroshi Takahashi, Hiromasa Igota, Mayumi Ueno, Yukiko Matsuura, Takashi Ikeda, Ryo Yoshizawa, Hino Takafumi, Tsuyoshi Yoshida   +9 more
wiley   +1 more source

Combining transient dynamics and logistic‐asymptotic growth to study the recovery of two seabird populations after rat eradication

Population Ecology, EarlyView.
This study examines the demographic dynamics of two seabird populations on Tromelin Island, 15 years after the eradication of brown rats. The results indicate that these populations are in good health and are expected to continue growing until breeding sites are saturated in about a century.
Merlène Saunier, Christophe Barbraud, Maxime Amy, Sabine Orlowski, Jean Hivert, Gabrielle Dicque, Matthieu Le Corre   +6 more
wiley   +1 more source

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

Frontiers in Bioengineering and Biotechnology, 2020
When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation.
Dania Movia, Solène Bruni-Favier, A. Prina‐Mello   +2 more
semanticscholar   +1 more source

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Organoid intelligence for developmental neurotoxicity testing

Frontiers in Cellular Neuroscience
The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intelligence
Dowlette-Mary Alam El Din, Jeongwon Shin, Alexandra Lysinger, Matthew J. Roos, Erik C. Johnson, Timothy J. Shafer, Thomas Hartung, Thomas Hartung, Thomas Hartung, Lena Smirnova   +9 more
doaj   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends

Metabolites
Metabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology and drug development.
Fenna Sillé, Thomas Hartung
doaj   +1 more source