Results 61 to 70 of about 4,831,623 (248)
Evidence-based AI: from trailblazer to trustblazer?
Frontiers in Artificial IntelligenceAgentic AI systems can plan, call tools, and coordinate specialized sub-agents, enabling multi-step scientific workflows that exceed what single-model text generation can reliably deliver.
Thomas Luechtefeld +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut +10 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2008 The development of the nervous system is a rather complex process known to be affected by different drugs and chemicals. Therefore, regulatory test guidelines have been adopted for the prediction and assessment of developmental neurotoxicity (U.S.EPA ...
Slawik,B. +6 more
core
From reference epigenomes to response epigenomes: a public-health case built on the developing brain
Frontiers in Public HealthReference epigenome projects, such as the NIH roadmap, ENCODE, and the international human epigenome consortium, have started mapping the baseline regulatory states of human cell types with extraordinary detail.
Thomas Hartung, Thomas Hartung
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The (misleading) role of animal models in drug development
Frontiers in Drug DiscoveryAnimals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project
Frontiers in Public HealthThe Human Exposome Project aims to map the totality of environmental exposures, but its success relies on transforming qualitative detections into quantitative data.
Fenna C. M. Sillé +8 more
doaj +1 more source