Results 1 to 10 of about 2,362 (186)

The data substrate of exposome intelligence: an interoperability profile for untargeted metabolomics [PDF]

Frontiers in Artificial Intelligence
Untargeted metabolomics, anchored in high-resolution mass spectrometry, has matured into the central analytical platform of human exposomics. It can capture endogenous biology, diet, drugs, microbial chemistry, environmental contaminants, and their ...
Thomas Hartung, Thomas Hartung
doaj   +2 more sources

Plasma or Serum? A Pilot Evaluation of Matrix Selection for Integrated Metabolomics and Exposomics of Clinical Samples [PDF]

Toxics
Serum and plasma are the most widely used matrices in metabolomics and human biomonitoring studies; however, the optimal matrix for integrated non-targeted analysis (NTA) workflows combining metabolomics and exposomics has not been systematically ...
Xiaowen Ji, Julian Edwards, Miaomiao Wang, Juan C. Irwin, Binya Liu, Amanda M. Gutierrez, Lin Li, Jeannette C. Lager, Camran R. Nezhat, David K. Stevenson, Tomiko T. Oskotsky, Marina Sirota, Dimitri Abrahamsson, Linda C. Giudice, Tracey J. Woodruff, Joshua F. Robinson, June-Soo Park   +16 more
doaj   +2 more sources

JPA: Joint Metabolic Feature Extraction Increases the Depth of Chemical Coverage for LC-MS-Based Metabolomics and Exposomics

Metabolites, 2022
Extracting metabolic features from liquid chromatography-mass spectrometry (LC-MS) data has been a long-standing bioinformatic challenge in untargeted metabolomics.
Shipei Xing, Tao Huan, Mingliang Fang
exaly   +3 more sources

Environmental Chemical Exposomics and Metabolomics in Toxicology: Recent Advances [PDF]

Toxics
This editorial introduces the Special Issue titled “State-of-the-Art Environmental Chemical Exposomics and Metabolomics—2nd Edition [...]
Minjian Chen
doaj   +2 more sources

Exposomics as a discovery engine for emerging contaminants and hidden biological risks

Emerging Contaminants
Over the past decade, exposome science has evolved from a conceptual framework into a practical discovery engine for environmental health. By combining high-resolution mass spectrometry, non-targeted analysis, multi-omics integration, wearable sensors ...
Oluwatobi Kolawole, Atallah Elzein, Tim Marczylo   +2 more
doaj   +2 more sources

CCDB: A database for exploring inter-chemical correlations in metabolomics and exposomics datasets

Environment International, 2022
Inter-chemical correlations in metabolomics and exposomics datasets provide valuable information for studying relationships among chemicals reported for human specimens.
Susan L Teitelbaum, Manish Arora, Dinesh K Barupal   +2 more
exaly   +3 more sources

Development and Application of an LC-MS/MS Untargeted Exposomics Method with a Separated Pooled Quality Control Strategy

Molecules, 2022
Pooled quality controls (QCs) are usually implemented within untargeted methods to improve the quality of datasets by removing features either not detected or not reproducible.
Emma L. Schymanski, Silvia Fustinoni, Gianfranco Frigerio   +2 more
exaly   +3 more sources

AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project [PDF]

Frontiers in Public Health
The Human Exposome Project aims to map the totality of environmental exposures, but its success relies on transforming qualitative detections into quantitative data.
Fenna C. M. Sillé, Karolina Kopańska, Carsten Prasse, Carsten Prasse, Thomas Luechtefeld, Thomas Luechtefeld, Thomas Hartung, Thomas Hartung, Thomas Hartung   +8 more
doaj   +2 more sources

Big Data, epistemology and causality: Knowledge in and knowledge out in EXPOsOMICS

Big Data and Society, 2016
Recently, it has been argued that the use of Big Data transforms the sciences, making data-driven research possible and studying causality redundant. In this paper, I focus on the claim on causal knowledge by examining the Big Data project EXPOsOMICS ...
Stefano Canali
exaly   +2 more sources

From toxicogenomics to predictive toxicology and exposomics: defining the next decade of gene–environment research [PDF]

Frontiers in Genetics
Over the past 15 years, genetics has undergone a profound transformation driven by advances in next-generation sequencing, multi-omics technologies, single-cell analysis, genome editing, and artificial intelligence.
Douglas M. Ruden
doaj   +2 more sources