Results 21 to 30 of about 2,584 (204)

The BDNF–TrkB–CREB Signalling Pathway Is Involved in Bisphenol S-Induced Neurotoxicity in Male Mice by Regulating Methylation

Toxics, 2022
Bisphenol S (BPS), the most common substitute for bisphenol A in manufacturing, is associated with neurotoxicity, but its molecular mechanisms are unclear.
Yi-Zhou Li, Zi-Yao Wu, Bi-Qi Zhu, Yu-Xiao Wang, Ya-Qi Kan, Huai-Cai Zeng   +5 more
doaj   +1 more source

The endogenous exposome [PDF]

DNA Repair, 2014
The concept of the Exposome, is a compilation of diseases and one’s lifetime exposure to chemicals, whether the exposure comes from environmental, dietary, or occupational exposures; or endogenous chemicals that are formed from normal metabolism, inflammation, oxidative stress, lipid peroxidation, infections, and other natural metabolic processes such ...
Nakamura, Jun, Mutlu, Esra, Sharma, Vyom, Collins, Leonard, Bodnar, Wanda, Yu, Rui, Lai, Yongquan, Moeller, Benjamin, Lu, Kun, Swenberg, James   +9 more
openaire   +4 more sources

Systematic Investigation of LC Miniaturization to Increase Sensitivity in Wide-Target LC-MS-Based Trace Bioanalysis of Small Molecules

Frontiers in Molecular Biosciences, 2022
Covering a wide spectrum of molecules is essential for global metabolome assessment. While metabolomics assays are most frequently carried out in microbore LC-MS analysis, reducing the size of the analytical platform has proven its ability to boost ...
Veronika Fitz, Veronika Fitz, Yasin El Abiead, Daniel Berger, Gunda Koellensperger, Gunda Koellensperger, Gunda Koellensperger   +6 more
doaj   +1 more source

Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches

Frontiers in Toxicology, 2023
Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid, Przemyslaw Piechota, Emily Golden, Mikhail Maertens, Thomas Hartung, Thomas Hartung, Alexandra Maertens   +6 more
doaj   +1 more source

Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth [PDF]

, 2022
BACKGROUND: Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing early-life exposures and
Alfano, R, Barros, H, Bustamante, M, Chatzi, L, De Kok, TM, Ghantous, A, Herceg, Z, Keski-Rahkonen, P, Nawrot, TS, Plusquin, M, Relton, CL, Richiardi, L, Robinson, O, Roumeliotaki, T, Scalbert, A, Vineis, P, Vrijheid, M, Zugna, D   +17 more
core   +4 more sources

A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events [PDF]

, 2022
Background: Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD).
Arpawong T. E., Cappozzo A., Chiodini P., Crimmins E. M., Fiorito G., Freni Sterrantino A., Iacoviello L., Ieva F., Kee F., Kenny R. A., Krogh V., McCrory C., McGuinness B., McKay G. J., McKnight A. J., O'Halloran A., Panico S., Polidoro S., Ricceri F., Robinson O., Sacerdote C., Sieri S., Solinas G., Tumino R., Vineis P., Young I. S.   +25 more
core   +5 more sources

A systematic comparison of linear regression-based statistical methods to assess exposome-health associations [PDF]

, 2016
BACKGROUND: The exposome constitutes a promising framework to better understand the effect of environmental exposures on health by explicitly considering multiple testing and avoiding selective reporting.
Benjamini Y, Benjamini Y, Bonferroni CE, Jelle Vlaanderen, Juan R. González, Lise Giorgis-Allemand, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Mark J. Nieuwenhuijsen, Martine Vrijheid, Oliver Robinson, Paolo Vineis, Roel Vermeulen, Rémy Slama, Tibshirani R, Valérie Siroux, Xavier Basagaña   +17 more
core   +7 more sources

Exposome Research in the Perspective of Longue Durée Political Epistemology [PDF]

Laboratorio dell'ISPF
Exposomics has become a leading framework for examining how lifelong environmental exposures shape human health. We draw on historical and philosophical scholarship to situate its political epistemology and outline possible future paths.
Thomas BONNIN , Stefano CANALI
doaj   +1 more source

Genetic variants of ERBB4 gene and risk of gestational diabetes mellitus: a susceptibility and diagnostic nomogram study

Frontiers in Endocrinology, 2023
IntroductionGestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of mothers and their offspring.
Ruiqi Li, Yukun Wang, Lin Yang, Ping Zhong, Gongchen Huang, Qiulian Liang, Xiangyuan Yu   +6 more
doaj   +1 more source

Assessing the Exposome with External Measures: Commentary on the State of the Science and Research Recommendations [PDF]

, 2017
The exposome comprises all environmental exposures that a person experiences from conception throughout the life course. Here we review the state of the science for assessing external exposures within ...
Anderson, Kim, Balshaw, David, Cui, Yuxia, Dunton, Genevieve, Hoppin, Jane A., Jerrett, Michael, Koutrakis, Petros, Nieuwenhuijsen, Mark J., Turner, Michelle C.   +8 more
core   +2 more sources