Results 41 to 50 of about 1,965 (197)

An Integrated Approach to the Exposome

Environmental Health Perspectives, 2012
The editorial by Lioy and Rappaport (2011) provides a timely addition to the discussion about the exposome and exposure science. We are encouraged by the recognition of the importance of combining measurements of personal exposure with measurements of biological markers of exposure.
van Tongeren, Martie; id_orcid 0000-0002-1205-1898, Cherrie, John W   +1 more
openaire   +3 more sources

Strengthening Causal Inference in Exposomics Research: Application of Genetic Data and Methods [PDF]

, 2022
Advances in technologies to measure a broad set of exposures have led to a range of exposome research efforts. Yet, these efforts have insufficiently integrated methods that incorporate genetic data to strengthen causal inference, despite evidence that ...
Avery, C.L., Engel, S.M., Buchanan, V.L., Lee, M.P., Downie, C.G., Ballou, A.F., Lilly, A.G., North, K.E., Staley, B.S., Rager, J.E., Gordon-Larsen, P., Lu, K., Howard, A.G., Graff, M., Collins, J.M., Highland, H.M.   +15 more
core   +2 more sources

Assessment of Exposure to Di-(2-ethylhexyl) Phthalate (DEHP) Metabolites and Bisphenol A (BPA) and Its Importance for the Prevention of Cardiometabolic Diseases

Metabolites, 2022
Exposomics analyses have highlighted the importance of biomonitoring of human exposure to pollutants, even non-persistent, for the prevention of non-communicable diseases such as obesity, diabetes, non-alcoholic fatty liver disease, atherosclerosis, and ...
Fabrizia Carli, Demetrio Ciociaro, Amalia Gastaldelli   +2 more
doaj   +1 more source

The influence of exposome on acne [PDF]

Journal of the European Academy of Dermatology and Venereology, 2018
AbstractBackgroundAcne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.AimTo assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome.MethodsTwo consensus meetings of five European ...
Dréno, Brigitte, Bettoli, Vincenzo, Araviiskaia, Elena, Sanchez Viera, Miguel, Bouloc, Anne   +4 more
openaire   +4 more sources

The alcohol exposome

Alcohol
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries.
Nousha H. Sabet, Todd A. Wyatt
openaire   +2 more sources

Adding open spectral data to MassBank and PubChem using open source tools to support non-targeted exposomics of mixtures [PDF]

, 2023
The term “exposome” is defined as a comprehensive study of life-course environmental exposures and the associated biological responses. Humans are exposed to many different chemicals, which can pose a major threat to the well-being of humanity.
Todor Kondić, Evan E. Bolton, Zhang, Jian, Kondić, Todor, SCHYMANSKI, Emma, Benjamin A. Shoemaker, Anjana Elapavalore, Elapavalore, Anjana, Paul A. Thiessen, Thiessen, Paul A., Emma L. Schymanski, Randolph R. Singh, Jian Zhang, Bolton, Evan E., Thiessen, Paul A, Singh, Randolph, Shoemaker, Benjamin A, Bolton, Evan E, Shoemaker, Benjamin A., Schymanski, Emma L.   +19 more
core   +1 more source

IDSL_MINT: a deep learning framework to predict molecular fingerprints from mass spectra

Journal of Cheminformatics
The majority of tandem mass spectrometry (MS/MS) spectra in untargeted metabolomics and exposomics studies lack any annotation. Our deep learning framework, Integrated Data Science Laboratory for Metabolomics and Exposomics—Mass INTerpreter (IDSL_MINT ...
Sadjad Fakouri Baygi, Dinesh Kumar Barupal   +1 more
doaj   +1 more source

Sinapic acid regulated the cardiometabolic and intestinal flora disorders to attenuate the myocardial fibrosis in HFD and STZ-induced diabetic mice

Food Science and Human Wellness
Myocardial fibrosis is a critical stage in the progression of diabetic cardiomyopathy (DCM). Sinapic acid (SA) is a plant phenolic acid compound with antimicrobial, antioxidant, and anti-inflammatory activities.
Chunxiang Huang, Keying Wang, Zhizhu Ke, Mingyu Zhang, Qiuping Huang, Chenxi Tong, Chuangzhi Yan, Zichun Song, Jiejing Xu, Tieming Jiang, Jiale Song   +10 more
doaj   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Biomonitoring in the Era of the Exposome [PDF]

Environmental Health Perspectives, 2017
The term "exposome" was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts.Our objectives were to describe why traditional and nontraditional ...
Dennis, Kristine K., Marder, Elizabeth, Balshaw, David M., Cui, Yuxia, Lynes, Michael A., Patti, Gary J., Rappaport, Stephen M., Shaughnessy, Daniel T., Vrijheid, Martine, Barr, Dana Boyd   +9 more
openaire   +2 more sources