Results 41 to 50 of about 2,362 (186)

Exposome in human health: Utopia or wonderland?

The Innovation, 2021
Summary: The current human exposome primarily emphasizes the total environmental exposure during an entire life. The characteristics of “lifelong” and “all environmental factors” make it very challenging to bring the exposomic study into real-life ...
Mingliang Fang, Ligang Hu, Da Chen, Yuming Guo, Jianmeng Liu, Changxin Lan, Jicheng Gong, Bin Wang   +7 more
doaj   +1 more source

Introduction to Exposomics

, 2019
Short course on Exposomics given at the Society of Environmental Toxicology and Chemistry (SETAC) 40th annual meeting November ...
elin ulrich (6671857)
core   +1 more source

PubChemLite for Exposomics

, 2020
PubChemLite is a subset of PubChem (https://pubchem.ncbi.nlm.nih.gov/) selected from major categories of the Table of Contents page at the PubChem Classification Browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=72).
Zhang, Jeff, Thiessen, Paul, SCHYMANSKI, Emma, Bolton, Evan, KONDIC, Todor, Zhang, Jian (Jeff)   +5 more
core   +1 more source

Large scale enzyme based xenobiotic identification for exposomics. [PDF]

, 2021
Advances in genomics have revealed many of the genetic underpinnings of human disease, but exposomics methods are currently inadequate to obtain a similar level of understanding of environmental contributions to human disease.
Woodworth, Michael H, Jones, Dean P, Castellanos, Francisco, Ziegler, Thomas R, Go, Young-Mi, Bais, Preeti, Lee, Choon M, Liu, Ken H, Singer, Grant, Miller, Gary W, Kraft, Colleen S, Morgan, Edward T, Li, Shuzhao   +12 more
core   +1 more source

The skin aging exposome [PDF]

Journal of Dermatological Science, 2017
The term "exposome" describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body's response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin ...
Krutmann, Jean, Bouloc, Anne, Sore, Gabrielle, Bernard, Bruno A., Passeron, Thierry   +4 more
openaire   +2 more sources

Assessing the Potential of Untargeted SWATH Mass Spectrometry-Based Metabolomics to Differentiate Closely Related Exposures in Observational Studies

Metabolites, 2022
Mass spectrometry (MS) is increasingly used in clinical studies to obtain molecular evidence of chemical exposures, such as tobacco smoke, alcohol, and drugs.
Frank Klont, Piotr Sosnowski, Daan Kremer, Tim J. Knobbe, Ron Bonner, Hans Blokzijl, Rinse K. Weersma, Stephan J. L. Bakker, TransplantLines Investigators, Eelko Hak, Daan J. Touw, Gérard Hopfgartner   +11 more
doaj   +1 more source

The alcohol exposome

Alcohol
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries.
Nousha H. Sabet, Todd A. Wyatt
openaire   +2 more sources

The exposome in atopic dermatitis [PDF]

Allergy, 2019
AbstractAtopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, in combination with genetic
Nicholas Stefanovic, Carsten Flohr, Alan D. Irvine   +2 more
openaire   +4 more sources

MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its high metastasis, high recurrence, and short survival time have always been a difficult and hot spot in clinical practice.
Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan, Xiaonian Zhu   +9 more
doaj   +1 more source

Sinapic acid regulated the cardiometabolic and intestinal flora disorders to attenuate the myocardial fibrosis in HFD and STZ-induced diabetic mice

Food Science and Human Wellness
Myocardial fibrosis is a critical stage in the progression of diabetic cardiomyopathy (DCM). Sinapic acid (SA) is a plant phenolic acid compound with antimicrobial, antioxidant, and anti-inflammatory activities.
Chunxiang Huang, Keying Wang, Zhizhu Ke, Mingyu Zhang, Qiuping Huang, Chenxi Tong, Chuangzhi Yan, Zichun Song, Jiejing Xu, Tieming Jiang, Jiale Song   +10 more
doaj   +1 more source