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The term "exposome" describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body's response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin ...
Krutmann, Jean +4 more
openaire +2 more sources
Chemical Exposomics in Human Plasma by Lipid Removal and Large Volume Injection Gas Chromatography High-Resolution Mass Spectrometry [PDF]
For comprehensive chemical exposomics in blood, analytical workflows are evolving through advances in sample preparation and instrumental methods. We hypothesized that gas chromatography high-resolution mass spectrometry (GC-HRMS) workflows could be ...
Bénilde, Bonnefille +6 more
core +1 more source
EXPOsOMICS: final policy workshop and stakeholder consultation [PDF]
The final meeting of the EXPOsOMICS project "Final Policy Workshop and Stakeholder Consultation" took place 28-29 March 2017 to present the main results of the project and discuss their implications both for future research and for regulatory and policy ...
Vrijheid, Martine +4 more
core +2 more sources
Progress of metabolomics‐centric multi‐omics research in medicine
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang +6 more
wiley +1 more source
Background: Electronic and electrical waste (e-waste) production has emerged to be of global environmental public health concern. E-waste workers, who are frequently exposed to hazardous chemicals through occupational activities, face considerable health
Zhiqiang Pang +4 more
doaj +1 more source
ABSTRACT Elevated rates of major depressive disorder and anxiety disorders in neurodivergent populations are often interpreted as evidence that autism, attention‐deficit/hyperactivity disorder, and affective disorders share intrinsic neurobiological pathology.
Darko Sarovic
wiley +1 more source
The exposome in atopic dermatitis [PDF]
AbstractAtopic dermatitis (AD) is a complex inflammatory disorder with multiple interactions between genetic, immune and external factors. The sum of external factors that an individual is exposed to throughout their lifetime is termed the exposome. The exposome spans multiple domains from population to molecular levels and, in combination with genetic
Nicholas Stefanovic +2 more
openaire +4 more sources
Enabling Quantitative Analysis of Surface Small Molecules for Exposomics and Behavioral Studies [PDF]
Workplace chemical exposures are a major source of occupational injury. Although over half of these are skin exposures, exposomics research often focuses on chemical levels in the air or in worker biofluids such as blood and urine.
Zongyuan Liu (1525858) +13 more
core +1 more source
Phospholipid Removal for Enhanced Chemical Exposomics in Human Plasma [PDF]
The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics ...
Kalliroi Sdougkou (11402189) +5 more
core +3 more sources
Serum and plasma are the most widely used matrices in metabolomics and human biomonitoring studies; however, the optimal matrix for integrated non-targeted analysis (NTA) workflows combining metabolomics and exposomics has not been systematically ...
Xiaowen Ji +16 more
doaj +1 more source

