Results 61 to 70 of about 2,362 (186)
The exposome for kidney stones [PDF]
Urolithiasis, 2015 The exposome is the assembly and measure of all the exposures of an individual in a lifetime. An individual's exposures begin before birth and include insults from environmental and occupational sources. The associated field is called exposomics, which relies on the application of internal and external exposure assessment methods.
openaire +2 more sources
Toxics, 2023 Bisphenol S (BPS) is an environmental pollutant that can accumulate in the human body and cause harm. Puerarin (PUE) is a flavonoid with anti-inflammatory and antioxidant effects.
Zi-Yao Wu +6 more
doaj +1 more source
The External Exposome and Food Allergy: How Environmental Exposures Shape Disease Risk
Allergy, EarlyView.ABSTRACT IgE‐mediated food allergy is a global health issue with rising prevalence that cannot be explained by genetic change alone, strongly suggesting that environmental exposures are a key driver. The external exposome encompasses several exposures that influence the developing immune system and modify food allergy risk.
Johanna M. Smeekens +5 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract External exposome research offers opportunities to evaluate complex relationships between multiple environmental determinants of Alzheimer's disease and related dementias (ADRD). However, selecting specific exposure domains, identifying metrics, and downloading, processing, and managing big data are key challenges in translating the potential ...
Zachary Popp +9 more
wiley +1 more source
Phospholipid removal for enhanced chemical exposomics in human plasma
, 2023 The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics ...
Xie, Hongyu +11 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Environmental exposures contribute substantially to Alzheimer's disease and related dementias (ADRD), yet comprehensive exposome‐wide investigations systematically evaluating multi‐domain environmental factors remain limited and lacking utility for precision medicine. METHODS We conducted an exposome‐wide association study (ExWAS)
Chenshuang Li +11 more
wiley +1 more source
Chemical Exposomics in Human Plasma by Lipid Removal and Large Volume Injection Gas Chromatography High-Resolution Mass Spectrometry [PDF]
For comprehensive chemical exposomics in blood, analytical workflows are evolving through advances in sample preparation and instrumental methods. We hypothesized that gas chromatography high-resolution mass spectrometry (GC-HRMS) workflows could be ...
Bénilde, Bonnefille +6 more
core +2 more sources
The Exposome: Molecules to Populations
Annual Review of Pharmacology and Toxicology, 2019 Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of ...
Niedzwiecki, Megan M. +5 more
openaire +4 more sources
Associations Between Kidney Function and Risk of Cognitive Impairment Among Chinese Older Adults
Geriatrics &Gerontology International, Volume 26, Issue 10, October 2026.This graphical abstract illustrates the association between kidney function and risk of cognitive impairment among Chinese older adults from the CLHLS cohort. Reduced eGFR and elevated ACR assessed at baseline were significantly associated with higher odds of both prevalent and incident cognitive impairment, after adjusting for sociodemographic and ...
Xin Wang +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei +18 more
wiley +1 more source