Results 61 to 70 of about 2,584 (204)

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

IDSL_MINT: a deep learning framework to predict molecular fingerprints from mass spectra

Journal of Cheminformatics
The majority of tandem mass spectrometry (MS/MS) spectra in untargeted metabolomics and exposomics studies lack any annotation. Our deep learning framework, Integrated Data Science Laboratory for Metabolomics and Exposomics—Mass INTerpreter (IDSL_MINT ...
Sadjad Fakouri Baygi, Dinesh Kumar Barupal   +1 more
doaj   +1 more source

Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS) [PDF]

, 2012
The goal of genome-wide association studies is to identify SNPs unique to disease. It usually involves a single sampling from subjects' lifetimes. While primary DNA sequence variation influences gene-expression levels, expression is also influenced by ...
Lahiri, Debomoy K., Maloney, Bryan
core   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers

Metabolites
Background: Electronic and electrical waste (e-waste) production has emerged to be of global environmental public health concern. E-waste workers, who are frequently exposed to hazardous chemicals through occupational activities, face considerable health
Zhiqiang Pang, Charles Viau, Julius N. Fobil, Niladri Basu, Jianguo Xia   +4 more
doaj   +1 more source

Epigenetic memory in response to environmental stressors [PDF]

, 2017
Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in several ways. Some exposures cause damage and alter the structure of DNA, but there is increasing evidence that the same or other environmental exposures ...
Aristotelis Chatziioannou, Dobrin R., James M. Flanagan, Joubert B. R., Lillycrop K. A., Mark Hanson, Micheline Kirsch‐Volders, Paolo Vineis, Soterios Kyrtopoulos, Vincent T. Cunliffe   +9 more
core   +1 more source

Progress of metabolomics‐centric multi‐omics research in medicine

iMetaOmics, EarlyView.
The graphical abstract illustrates a holistic roadmap for metabolomics‐centric multi‐omics integration in medical research. The upper panel depicts the technological transition from traditional bulk analysis to high‐resolution single‐cell and spatial methodologies, specifically addressing inherent challenges such as molecular complexity and dynamic ...
Ziyi Wang, Shiwen Deng, Xiaoxu Wang, Xiao Chang, Na Guo, Peng Chen, Hongjun Yang   +6 more
wiley   +1 more source

The alcohol exposome

Alcohol
Science is now in a new era of exposome research that strives to build a more all-inclusive, panoramic view in the quest for answers; this is especially true in the field of toxicology. Alcohol exposure researchers have been examining the multivariate co-exposures that may either exacerbate or initiate alcohol-related tissue/organ injuries.
Nousha H. Sabet, Todd A. Wyatt
openaire   +2 more sources

Empowering large chemical knowledge bases for exposomics: PubChemLite meets MetFrag

Journal of Cheminformatics, 2021
Compound (or chemical) databases are an invaluable resource for many scientific disciplines. Exposomics researchers need to find and identify relevant chemicals that cover the entirety of potential (chemical and other) exposures over entire lifetimes ...
Emma L. Schymanski, Todor Kondić, Steffen Neumann, Paul A. Thiessen, Jian Zhang, Evan E. Bolton   +5 more
doaj   +1 more source

Association between proximity to a lead‐releasing facility and cognition in diverse cohorts

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract BACKGROUND The associations between adult lead exposure and late‐life cognition are largely unknown. METHODS In two cohorts, Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE, n = 1638) and Study of Healthy Aging in African Americans (STAR, n = 741), we assessed residential proximity to lead‐releasing facilities for association with ...
Scarlet Cockell, Kelly M. Bakulski, Ai‐Lin Tsai, Yike Liu, Amanda J. Goodrich, Chinomnso N. Okorie, Stacey Alexeeff, Rachel A. Whitmer, Paola Gilsanz, Kathryn C. Conlon   +9 more
wiley   +1 more source