Results 51 to 60 of about 1,965 (197)

MAZ-mediated N6-methyladenosine modification of ZEB1 promotes hepatocellular carcinoma progression by regulating METTL3

Journal of Translational Medicine
Background Hepatocellular carcinoma (HCC) has a hidden onset and high malignancy. Its high metastasis, high recurrence, and short survival time have always been a difficult and hot spot in clinical practice.
Di Li, Li Xu, Ruyuan Liu, Zhaonv Yao, Chuanjun Zheng, Song Jin, Xuefeng Guo, Zhengbao Zhang, Shengkui Tan, Xiaonian Zhu   +9 more
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Biomarkers intersect with the exposome [PDF]

Biomarkers, 2012
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies.
openaire   +2 more sources

Cheminformatics and High Resolution Mass Spectrometry in Historical Exposomics of the Minette Region [PDF]

, 2022
Platform Presentation for IMSC2022 in Maastricht Cheminformatics and High Resolution Mass Spectrometry in Historical Exposomics of the Minette Region Aurich D.1, Diderich P.2, Schymanski E.L.1 1 Luxembourg Centre for Systems Biomedicine (LCSB ...
Schymanski, Emma, Diderich, Philippe, Aurich, Dagny   +2 more
core   +1 more source

Puerarin Prevents Bisphenol S Induced Lipid Accumulation by Reducing Liver Lipid Synthesis and Promoting Lipid Metabolism in C57BL/6J Mice

Toxics, 2023
Bisphenol S (BPS) is an environmental pollutant that can accumulate in the human body and cause harm. Puerarin (PUE) is a flavonoid with anti-inflammatory and antioxidant effects.
Zi-Yao Wu, Li Luo, Ya-Qi Kan, Mei-Lin Qin, Hai-Ting Li, Qing-Zhi He, Huai-Cai Zeng   +6 more
doaj   +1 more source

Postcode‐Level Variation and Environmental Determinants of Respiratory Allergies in a Large German Cohort

Allergy, EarlyView.
Young children (0–9 years) and residents of urban areas appeared particularly vulnerable to respiratory allergy development and exacerbation. Incidence showed nonlinear associations with PM10, PM2.5, temperature, and alder/birch pollen, while DPMR showed similar patterns, except for NO2 and the interaction O3*NO2.
Trang Dao‐Siebel, Christoph Knote, Christoph Müller, Thilo Erbertseder, Elke Hertig, Roxana Halbleib, Evelyn Lamy   +6 more
wiley   +1 more source

The Alzheimer's Disease Exposome

Alzheimer's & Dementia, 2019
AbstractIntroductionEnvironmental factors are poorly understood in the etiology of Alzheimer's disease (AD) and related dementias. The importance of environmental factors in gene environment interactions (GxE) is suggested by wide individual differences in cognitive loss, even for carriers of AD‐risk genetic variants.Results and DiscussionWe propose ...
Caleb E, Finch, Alexander M, Kulminski
openaire   +4 more sources

The Exposome: Molecules to Populations

Annual Review of Pharmacology and Toxicology, 2019
Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the phenome of an individual. The measurement of complex environmental factors that exert pressure on our health has not kept pace with genomics and historically has not provided a similar level of ...
Niedzwiecki, Megan M., Walker, Douglas I., Vermeulen, Roel, Chadeau-Hyam, Marc, Jones, Dean P., Miller, Gary W.   +5 more
openaire   +4 more sources

Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis

Toxics
This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and hepatocellular carcinoma (HCC).
Yulun Jian, Yuhan Li, Yanfeng Zhou, Wei Mu   +3 more
doaj   +1 more source

The Educational Exposome: A life‐course socioenvironmental framework for advancing Alzheimer's disease and ADRD research

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The exposome encompasses all environmental exposures across the life course, yet educational environments, a critical socioenvironmental exposure, remain underexplored despite their role in cognitive aging and Alzheimer's disease and related dementias (AD/ADRD).
Kimson E. Johnson
wiley   +1 more source