Results 51 to 60 of about 2,362 (186)

IDSL_MINT: a deep learning framework to predict molecular fingerprints from mass spectra

Journal of Cheminformatics
The majority of tandem mass spectrometry (MS/MS) spectra in untargeted metabolomics and exposomics studies lack any annotation. Our deep learning framework, Integrated Data Science Laboratory for Metabolomics and Exposomics—Mass INTerpreter (IDSL_MINT ...
Sadjad Fakouri Baygi, Dinesh Kumar Barupal   +1 more
doaj   +1 more source

Pollutants in Microenvironmental Cellular Interactions During Liver Inflammation Cancer Transition and the Application of Multi-Omics Analysis

Toxics
This study categorizes pollutant-induced inflammation–cancer transition into three stages: non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and hepatocellular carcinoma (HCC).
Yulun Jian, Yuhan Li, Yanfeng Zhou, Wei Mu   +3 more
doaj   +1 more source

Exposure to micro- and nano-plastics: From human internal burden to systems-level health-risk interpretation. [PDF]

Imeta
Micro‐ and nano‐plastics (MNPs) can enter the human body through inhalation, ingestion, contact with consumer products, and iatrogenic routes. The clinical relevance of MNP exposure should be interpreted at three levels: barrier interaction, cellular stress, and system‐level disruption, with key mechanisms including oxidative stress, mitochondrial ...
Tu C, Yang J, Liao J, Hu R, Feng Y, Wu D, Xia Y, Wang D, Tang J, Yuan X, Zhu D, Wei J, Xu L, Xu M, Guo X, Zhao J, Chen Q, Zhang Z, Li L, Ma Y, Jiang X, Zhang K, Peng C, Li M, Shen N, Peijnenburg WJGM, Rillig MC, White JC, Luo Y, Zhao N.   +29 more
europepmc   +2 more sources

Mass Spectrometry in Authentication and Forensic Approaches for Determining the Origin of Hazardous Chemicals

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi, Grégoire Delaporte, Christine Albaret, Emmanuel Joubert, Anne Bossée, Emilien L. Jamin, Laurent Debrauwer   +6 more
wiley   +1 more source

Biomarkers intersect with the exposome [PDF]

Biomarkers, 2012
The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies.
openaire   +2 more sources

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers

Metabolites
Background: Electronic and electrical waste (e-waste) production has emerged to be of global environmental public health concern. E-waste workers, who are frequently exposed to hazardous chemicals through occupational activities, face considerable health
Zhiqiang Pang, Charles Viau, Julius N. Fobil, Niladri Basu, Jianguo Xia   +4 more
doaj   +1 more source

Biomonitoring in the Era of the Exposome [PDF]

Environmental Health Perspectives, 2017
The term "exposome" was coined in 2005 to underscore the importance of the environment to human health and to bring research efforts in line with those on the human genome. The ability to characterize environmental exposures through biomonitoring is key to exposome research efforts.Our objectives were to describe why traditional and nontraditional ...
Dennis, Kristine K., Marder, Elizabeth, Balshaw, David M., Cui, Yuxia, Lynes, Michael A., Patti, Gary J., Rappaport, Stephen M., Shaughnessy, Daniel T., Vrijheid, Martine, Barr, Dana Boyd   +9 more
openaire   +2 more sources

Postcode‐Level Variation and Environmental Determinants of Respiratory Allergies in a Large German Cohort

Allergy, EarlyView.
Young children (0–9 years) and residents of urban areas appeared particularly vulnerable to respiratory allergy development and exacerbation. Incidence showed nonlinear associations with PM10, PM2.5, temperature, and alder/birch pollen, while DPMR showed similar patterns, except for NO2 and the interaction O3*NO2.
Trang Dao‐Siebel, Christoph Knote, Christoph Müller, Thilo Erbertseder, Elke Hertig, Roxana Halbleib, Evelyn Lamy   +6 more
wiley   +1 more source