Results 81 to 90 of about 2,584 (204)

Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Systems immunology provides a transformative framework for decoding human immune complexity. This review evaluates high‐throughput technologies and provides a roadmap for navigating analytical challenges—such as batch effects and interindividual heterogeneity—to successfully translate multimodal data into meaningful biological insights.
Lennart Riemann, Reinhold Förster
wiley   +1 more source

A post-Brexit agreement for research and innovation Outcomes from a simulated negotiation process. Bruegel Special Report 28 January 2020 [PDF]

, 2020
The UK will leave the European Union on 31 January 2020. Negotiators and commentators have spent more than three years discussing the terms on which the UK will withdraw, but comparatively little attention has been paid to the future relationship between
Leigh, Michael, Thompson, Beth, Veugelers, Reinhilde.   +2 more
core  

Mathematical Modelling of Metabolic Regulation in Aging [PDF]

, 2015
The underlying cellular mechanisms that characterize aging are complex and multifaceted. However, it is emerging that aging could be regulated by two distinct metabolic hubs.
Angell, Peter J., McAuley, Mark T., Mooney, Kathleen M, Wilkinson, Stephen J   +3 more
core   +5 more sources

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, Volume 13, Issue 11, 23 February 2026.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Examining Atopic Dermatitis Through the One Health Concept Lens

Allergy, Volume 81, Issue 2, Page 345-357, February 2026.
ABSTRACT This paper explores the application of the One Health framework to atopic dermatitis (AD), a complex, chronic skin disease, emphasizing interdisciplinary approaches to prevention and management. One Health integrates human, animal, environmental, and plant health, addressing challenges such as antimicrobial resistance, infectious diseases, and
Dijana Minić‐Pantić, Bernadette Abela, Jenni Lehtimäki, Alexander Zink, Erika Jensen‐Jarolim, Antonia Fettelschoss‐Gabriel, Claudia Traidl‐Hoffmann, Johannes Ring, Peter Schmid‐Grendelmeir, Pascal Prélaud, Alain Taïeb   +10 more
wiley   +1 more source

Liraglutide Ameliorates Injury‐Related Vascular Repair by Activating Autophagy Through Modulation of the PI3K–mTOR Signaling Pathway

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Liraglutide inhibits chronic stress‐induced vascular injury in mice by inhibiting the activation of the PI3K‐mTOR signaling pathway and promoting autophagy of smooth muscle cells or macroautophagy. ABSTRACT Chronic stress is a significant risk factor for postoperative restenosis and other cardiovascular diseases, as it can promote the intimal ...
Zongyi Zhang, Guixian Wu, Chaozhi Xu, Shanqian Li, Yulin Zhang, Yue Hu, Wanhua Wu, Hongyu Ding, Yuling Liu, Yue Huang, Wenjun Lu, Meimei Zheng, Yue Zhang, Hongxian Wu, Lina Hu   +14 more
wiley   +1 more source

The AD Exposome

International Journal of Biomedical Science, 2023
Efforts to find human genes for Alzheimer Disease and for longevity have generally neglected environmental influences. Brain aging and ADRDA may be understood in the AD Exposome framework, which includes external and endogenous interactions from embryo to old age (Finch and Kulminski 2019; Finch and Haghani 2021).
openaire   +1 more source

High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage [PDF]

In the modern “omics” era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a leading ...
Bessonneau, Vincent, Bowden, John, Castilla-Fernández, Delia, David, Arthur, Koelmel, Jeremy P., Lai, Yunjia, Manz, Katherine E., Nikiforov, Vladimir, Papazian, Stefano, Price, Elliott J., Walker, Douglas I   +10 more
core   +5 more sources

The fat‐heart entanglement and the role of ‘osteopontin mechanics’ in cardiometabolic senescence

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Abstract Background Residual cardiovascular (CV) risk persists despite therapeutic advances. Obesity is heterogeneous, and visceral adipose tissue (VAT) dysfunction (‘adiposopathy’) complicates risk stratification. Osteopontin (OPN) is a pleiotropic mediator implicated in VAT inflammation, senescence‐associated pathways, atherosclerosis and myocardial ...
Cristina Michelauz, Fabrizio Montecucco, Luca Liberale, Federico Carbone   +3 more
wiley   +1 more source