Results 91 to 100 of about 2,362 (186)

Identification of environmental etiologies of neurodevelopmental disorders in children

生物医学转化
Neurodevelopmental disorders (NDDs) are a group of chronic developmental brain dysfunctions caused by various genetic or acquired factors, characterized by high disability rates and a lack of effective treatments.
Li Yuanyuan
doaj   +1 more source

Phospholipid Removal for Enhanced Chemical Exposomics in Human Plasma

The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics ...
Kalliroi Sdougkou (11402189), Stefano Papazian (11402186), Ingvar A. Bergdahl (7306061), Jonathan W. Martin (674096), Hongyu Xie (11304477), Bénilde Bonnefille (13840889)   +5 more
core   +2 more sources

AI redefines mass spectrometry chemicals identification: retention time prediction in metabolomics and for a Human Exposome Project

Frontiers in Public Health
The comprehensive identification of environmental and endogenous chemicals in human biospecimens is a critical bottleneck for realizing the Human Exposome Project.
Fenna C. M. Sillé, Carsten Prasse, Carsten Prasse, Thomas Luechtefeld, Thomas Luechtefeld, Thomas Hartung, Thomas Hartung   +6 more
doaj   +1 more source

Identifying Small Molecules in Untargeted Exposomics Data: A case study of Thirdhand Smoke

, 2019
Identifying Small Molecules in Untargeted Exposomics Data: A case study of Thirdhand ...
Schymanski, Emma, Noelia Ramirez, Noelia Ramirez (3117267), Torres, Sonia, Ramirez, Noelia, Sonia Torres, Sonia Torres (8294760), Schymanski, Emma (6548762)   +7 more
core   +1 more source

Microextraction Technologies as Exposomic Sensors for On-Site Environmental Air Monitoring of Volatile Organic Compounds: A Review of Commercially Available Technologies

Molecules
Microextraction Technologies (METs) have emerged as pivotal exposomic sensors for the on-site monitoring of Volatile Organic Compounds (VOCs) in ambient air.
Stefano Dugheri, Nicola Mucci, Ilaria Rapi, Giovanni Cappelli, Ettore Guerriero, Fabio Cioni, Domenico Cipriano, Ivana Stanimirova, Veronica Traversini, Antonio Baldassarre, Riccardo Gori   +10 more
doaj   +1 more source

Development of LC-MS/MS Database Based on 250 Potentially Highly Neuroactive Compounds and Their Metabolites

Metabolites
Background: Environmental chemicals are hypothesized to contribute to the development of neurodevelopmental disorders; however, only a fraction of the thousands of chemicals in common commercial use have validated assays.
Taylor Teitelbaum, Haoduo Zhao, Lauren E. Koval, Yun-Chung Hsiao, Chih-Wei Liu, Julia E. Rager, Stephanie M. Engel, Kun Lu   +7 more
doaj   +1 more source

Using Hydrogen/Deuterium Exchange in Untargeted LC-MS Analysis of Small Molecules

Analytica
Liquid chromatography–hydrogen/deuterium exchange–mass spectrometry (LC-HDX-MS) provides orthogonal structural information that complements conventional LC-MS and improves confidence in small-molecule structural elucidation.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Veronika Hola, Michaela Paucova, Michaela Novakova, Oliver Fiehn   +6 more
doaj   +1 more source

Lentinan Improves Sodium Arsenite-Induced Hepatic Lipid Accumulation and Ferroptosis: Role of AMPK Signaling Pathway

Toxics
Sodium arsenite (SA) is an environmental chemical toxin that induces hepatotoxicity and cellular ferroptosis under exposure. Ferroptosis is characterized by elevated ferrous ion levels and decreased glutathione peroxidase 4 (GPX4) activity. Lentinan (LNT)
Shunli Luo, Yekang Deng, Yan Lu, Yuan Yang   +3 more
doaj   +1 more source

Chemical- and effect-oriented exposomics: Three Gorges Reservoir (TGR)

, 2013
Exposomic studies of the rapidly changing environment of the Three Gorges Reservoir (TGR) after its impounding is elaborated as a novel field of human and environmental research.
Wang, Jingxian, Schramm, Karl-Werner, Temoka, Cedrique, Scherb, Hagen, Schramm, KW (reprint author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Mol EXpos MEX, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany., Pfister, Gerd, Henkelmann, Bernhard, Bi, Yonghong   +7 more
core   +1 more source

Exposome Shiny: a Toolbox for exposome data analysis

, 2021
The exposome is a collection of environmental factors, such as air pollution, stress and diet, to which an individual is exposed and which can have an effect on health. There are several large projects aimed at the study of the exposome and their impact on human traits such as HELIX, EXPOsOMICS and Hercules among others.
openaire   +1 more source