Results 111 to 120 of about 1,965 (197)

Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress

Toxics
Bisphenol S (BPS) is a typical endocrine disruptor associated with obesity. To observe BPS effects on lipid metabolism in HepG2 and SK-Hep-1 human HCC cells, a CCK-8 assay was used to assess cell proliferation in response to BPS, and the optimal ...
Kai-Xing Lin, Zi-Yao Wu, Mei-Lin Qin, Huai-Cai Zeng   +3 more
doaj   +1 more source

The role and mechanism of miR-425–3p regulating neuronal pyroptosis -mediated inorganic arsenic-induced generalized anxiety disorder

Ecotoxicology and Environmental Safety
Pyroptosis plays a critical role in the pathogenesis of mental disorders. However, its specific role and mechanism in arsenic (As)-induced generalized anxiety disorder (GAD) remain elusive.
Wei-Xing Lei, Lei Zhang, Jin-Li Chen, Gao-Hui Zheng, Lin-Nan Guo, Tao Jiang, Zi-yue Yin, Ming-Ying, Qi-ming Yu, Na Wang   +9 more
doaj   +1 more source

Exposomics by Liquid Chromatography-ESI-Drift-Tube Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry: A Proof-of-Principle Study [PDF]

, 2017
Exposomics is challenging due to the low abundance, vast dynamic range, and structural diversity of exposome molecules, and is further complicated by matrix effects.
Lai, Yunjia
core  

Functional genetic variants and susceptibility and prediction of gestational diabetes mellitus

Scientific Reports
The aetiological mechanism of gestational diabetes mellitus (GDM) has still not been fully understood. The aim of this study was to explore the associations between functional genetic variants screened from a genome-wide association study (GWAS) and GDM ...
Gongchen Huang, Yan Sun, Ruiqi Li, Lei Mo, Qiulian Liang, Xiangyuan Yu   +5 more
doaj   +1 more source

Exposome-wide Association Study for Metabolic Syndrome

Frontiers in Genetics, 2021
Peng Gao, Michael Snyder
doaj   +1 more source

Sequencing the exposome: A call to action

Toxicology Reports, 2016
The exposome is a complement to the genome that includes non-genetic causes of disease. Multiple definitions are available, with salient points being global inclusion of exposures and behaviors, and cumulative integration of associated biologic responses. As such, the concept is both refreshingly simple and dauntingly complex. This article reviews high-
openaire   +3 more sources

Mechanistic insights and ameliorative strategies: advances in DEHP-induced metabolic toxicity and intervention by natural bioactive compounds and probiotics

Lipids in Health and Disease
Di-(2-ethylhexyl) phthalate (DEHP) is a ubiquitous plasticizer and environmental contaminant linked to severe metabolic disorders. This review concisely elucidates the multi-organ mechanisms of DEHP-induced toxicity, highlighting its disruption of lipid,
Huanyu Cui, Yansong Hu, Ye Tang, Tingzhuang Yi, Shengkui Tan, Zhengbao Zhang, Xiaonian Zhu   +6 more
doaj   +1 more source

Pathways through the Exposome

The prevalence of cardiometabolic diseases (CMD), including type 2 diabetes (T2D), is increasing globally. The proportion of genetic predisposition explaining cardiometabolic disease risk is around 20%. Other contributors to CMD risk include lifestyle and environmental factors, such as diet, sleep quality and duration, stress, air pollution, and ...
openaire   +3 more sources

Exposomics Crosses the Rubicon: Let the Building Begin. [PDF]

Environ Sci Technol
Miller GW, Habre R, Patel CJ.
europepmc   +1 more source

Vision for Exposomics-Scale Investigation: A Heuristic for Exposure-Wide Association Studies (ExWAS). [PDF]

Environ Sci Technol
Patel CJ, Miller GW, Motsinger-Reif AA.
europepmc   +1 more source