Evidence-based AI: from trailblazer to trustblazer?
Frontiers in Artificial IntelligenceAgentic AI systems can plan, call tools, and coordinate specialized sub-agents, enabling multi-step scientific workflows that exceed what single-model text generation can reliably deliver.
Thomas Luechtefeld +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Induced cytotoxicity revealed species diversity of rat and human lung tissue by repeated chemical exposure [PDF]
, 2022 S.53The use of high animal numbers and the suffering of animals in experiments such as repeated dose toxicity studies (RDT) demand for alternative test approaches. This can be done by grouping of chemicals to reduce in vivo studies.
Braubach, Peter +8 more
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Alternatives to the use of animals in safety testing as required by the EU-Cosmetics Directive 2009 [PDF]
, 2009 Ingredients of cosmetic products are no longer allowed to be tested by animal experimentation (EU-Cosmetics Directive 76/768 EEC). For several toxicological endpoints this testing ban applies since March 11, 2009, while repeated dose toxicity tests and ...
Vogel, R.
core
Cigarette smoke and cigarette smoke condensate induce cell injury and early biomarkers of inflammation in human and rodent Precision-Cut Lung Slices [PDF]
, 2022 S.173The use of high animal numbers and the suffering of animals in experiments such as repeated dose toxicity studies (RDT)demand for alternative test approaches. This can be done by grouping of chemicals to reduce in vivo studies.
Braubach, Peter +6 more
core
Science Communication in Alternatives to Animal testing: Raising awareness beyond the community [PDF]
, 2014 Session IX-6: Breaking down barriers and promoting international cooperation on 3RsSession IX-6: Breaking down barriers and promoting international cooperation on ...
Demortain, David, Busquet, François
core +4 more sources
AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project
Frontiers in Public HealthThe Human Exposome Project aims to map the totality of environmental exposures, but its success relies on transforming qualitative detections into quantitative data.
Fenna C. M. Sillé +8 more
doaj +1 more source
Give meaning to alternative methods to animal testing
ALTEX, 2019 n ...
Arti Ahluwalia, Anna Maria Bassi
openaire +4 more sources