Results 71 to 80 of about 455 (211)

Medical Devices Biological Safety Assessment: Towards Animal-free Testing

Derecho Animal, 2019
Animals have been used since a very long time as experimental subjects to support scientific progress and medical advances. Currently, various testing procedures implying animals are still being conducted within a broad range of scientific fields and ...
Nadège Sachot, Augusto Vitale
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Toxicity testing: the search for an in vitro alternative to animal testing

British Journal of Biomedical Science, 2009
Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to reduce the number of animals used for this purpose due to concerns such as the lack of concordance seen ...
May, J. E., Xu, J., Morse, H. R., Avent, N. D., Donaldson, C.   +4 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

AI: the Apollo guidance computer of the Exposome moonshot

Frontiers in Artificial Intelligence
The Exposome—the totality of environmental exposures across a lifetime—remains one of the most significant challenges in understanding and preventing human disease.
Fenna C. M. Sillé, Thomas Hartung, Thomas Hartung, Thomas Hartung   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Animais em aulas práticas: podemos substituí-los com a mesma qualidade de ensino?

Revista Brasileira de Educação Médica
Com o objetivo de verificar a possibilidade de substituição de animais em aulas práticas, comparou-se o grau de aprendizagem entre duas turmas do curso de Medicina submetidas a aulas distintas, com e sem o uso de animais.
Renata Diniz, Ana Lúcia dos Anjos Duarte, Charles Artur Santos de Oliveira, Marcello Romiti   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Navigating the unseen peril: safeguarding medical imaging in the age of AI

Frontiers in Artificial Intelligence
In response to the increasing significance of artificial intelligence (AI) in healthcare, there has been increased attention – including a Presidential executive order to create an AI Safety Institute – to the potential threats posed by AI.
Alexandra Maertens, Steve Brykman, Thomas Hartung, Thomas Hartung, Andrei Gafita, Harrison Bai, David Hoelzer, Ed Skoudis, Channing Judith Paller   +8 more
doaj   +1 more source

New trends on alternative to animal testings in Japan

Folia Pharmacologica Japonica, 2018
Non-animal alternative test methods have developed in the field of genotoxicity, endocrine disrupter, irritation and skin sensitization, and these are used the safety evaluation of chemical, pesticide, pharmaceutical and cosmetic for regulatory use. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity, immunotoxicity and ...
openaire   +3 more sources