Results 71 to 80 of about 284,210 (304)
Next generation validation for next generation risk assessment
Frontiers in ToxicologyNext generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro methods, are increasingly inadequate ...
Karolina Kopańska +5 more
doaj +1 more source
International cooperation for alternatives to animal testing
Folia Pharmacologica Japonica, 2011 動物実験代替法（以下，代替法と記す）の開発を促すために各国に設立された代替法バリデーションセンターの協調を図るため，2009年に日米欧カナダの参加で，代替試験法協力国際会議（ICATM: International Cooperation on Alternative Test Methods）の覚書が交わされ，代替法の開発に国際協調がより重要視されることになった．さらに，2011年には韓国の追加参入が決まり，新たな覚書が交わされた．このICATMの取り決めに準じた日本動物実験代替法評価センター（JaCVAM: Japanese Center for the Validation of Alternative Methods）の活動状況および今後の国際対応についてまとめた．本来なら ...
openaire +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The (misleading) role of animal models in drug development
Frontiers in Drug DiscoveryAnimals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
Socio-economic impacts of alternative GIN control practices. Project deliverable 11 (WP4) [PDF]
, 2018 This report is a deliverable (WP4) from the EU-funded PrOPara project. The PrOPara project aspires to i) assess existing knowledge from research, development and benchmarking studies on alternatives to parasite control on organic ruminant farms, ii ...
Moakes, Simon, Quiédeville, Sylvain
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Give meaning to alternative methods to animal testing
ALTEX, 2019 n ...
Arti Ahluwalia, Anna Maria Bassi
openaire +4 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project
Frontiers in Public HealthThe Human Exposome Project aims to map the totality of environmental exposures, but its success relies on transforming qualitative detections into quantitative data.
Fenna C. M. Sillé +8 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source