Results 91 to 100 of about 284,210 (304)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

AI: the Apollo guidance computer of the Exposome moonshot

Frontiers in Artificial Intelligence
The Exposome—the totality of environmental exposures across a lifetime—remains one of the most significant challenges in understanding and preventing human disease.
Fenna C. M. Sillé, Thomas Hartung, Thomas Hartung, Thomas Hartung   +3 more
doaj   +1 more source

In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria. [PDF]

, 2019
The objective of this study was to determine the in vitro antimicrobial activity of several organic acids and their derivatives against Gram-positive (G+) and Gram-negative (G-) bacteria.
Atwill, Edward Robert, Kovanda, Lauren, Li, Xunde, Liu, Yanhong, Luo, Jia, Vaessen, Stefan, Wei, Xiaohong, Wu, Xixi, Zhang, Wen   +8 more
core   +1 more source

Toxicity testing: the search for an in vitro alternative to animal testing

British Journal of Biomedical Science, 2009
Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to reduce the number of animals used for this purpose due to concerns such as the lack of concordance seen ...
May, J. E., Xu, J., Morse, H. R., Avent, N. D., Donaldson, C.   +4 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Animais em aulas práticas: podemos substituí-los com a mesma qualidade de ensino?

Revista Brasileira de Educação Médica
Com o objetivo de verificar a possibilidade de substituição de animais em aulas práticas, comparou-se o grau de aprendizagem entre duas turmas do curso de Medicina submetidas a aulas distintas, com e sem o uso de animais.
Renata Diniz, Ana Lúcia dos Anjos Duarte, Charles Artur Santos de Oliveira, Marcello Romiti   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Navigating the unseen peril: safeguarding medical imaging in the age of AI

Frontiers in Artificial Intelligence
In response to the increasing significance of artificial intelligence (AI) in healthcare, there has been increased attention – including a Presidential executive order to create an AI Safety Institute – to the potential threats posed by AI.
Alexandra Maertens, Steve Brykman, Thomas Hartung, Thomas Hartung, Andrei Gafita, Harrison Bai, David Hoelzer, Ed Skoudis, Channing Judith Paller   +8 more
doaj   +1 more source

Beyond Equal: From Same but Different to the Doctrine of Substantial Equivalence [PDF]

, 2008
A same-but-different dichotomy has recently been encapsulated within the ill-defined concept of “substantial equivalence”. By invoking this concept the genetically modified organism (GMO) industry has escaped the rigors of safety testing that might ...
Paull, John
core  

New trends on alternative to animal testings in Japan

Folia Pharmacologica Japonica, 2018
Non-animal alternative test methods have developed in the field of genotoxicity, endocrine disrupter, irritation and skin sensitization, and these are used the safety evaluation of chemical, pesticide, pharmaceutical and cosmetic for regulatory use. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity, immunotoxicity and ...
openaire   +3 more sources