Results 71 to 80 of about 282,052 (348)
The (misleading) role of animal models in drug development
Frontiers in Drug DiscoveryAnimals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
2001 Consultation of organic farming research priorities in the UK [PDF]
, 2001 The following reports a consultation of organic farming research priorities in the UK in 2001. The information was collated by Organic Centre Wales, Institute of Rural Studies, University of Wales, Aberystwyth on behalf of MAFF organic farming unit and
Lampkin, Nic +2 more
core
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Give meaning to alternative methods to animal testing
ALTEX, 2019 n ...
Arti Ahluwalia, Anna Maria Bassi
openaire +3 more sources
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Frontiers in Public HealthThe comprehensive identification of environmental and endogenous chemicals in human biospecimens is a critical bottleneck for realizing the Human Exposome Project.
Fenna C. M. Sillé +6 more
doaj +1 more source
Medical Devices Biological Safety Assessment: Towards Animal-free Testing
Derecho Animal, 2019 Animals have been used since a very long time as experimental subjects to support scientific progress and medical advances. Currently, various testing procedures implying animals are still being conducted within a broad range of scientific fields and ...
Nadège Sachot, Augusto Vitale
doaj +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Confronting the bias towards animal experimentation (animal methods bias)
Frontiers in Drug DiscoveryLaws and policies are in place around the world to promote the replacement and reduction of nonhuman animals in science. These principles are rooted not just in ethical considerations for animals, but also in scientific considerations regarding the ...
Catharine E. Krebs +2 more
doaj +1 more source
Giving meaning to alternative methods to animal testing
ALTEX, 2018 The 3 rd edition of the advanced theoretical-training course “ Giving meaning to alternative methods to animal testing ” was held in Genoa on July 6-7, 2017. The theoretical modules included talks by specialists from companies engaged in the field of advanced in vitro technologies, who offered participants the possibility to try out their technologies ...
Scanarotti C +7 more
openaire +3 more sources