Results 71 to 80 of about 923,548 (275)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Conscientious Objection to Animal Testing: A Preliminary Survey Among Italian Medical and Veterinary Students

Alternatives to laboratory animals : ATLA, 2019
The use of animals for educational and research purposes is common in both veterinary and human medicine degree courses, and one that involves important ethical considerations.
I. Baldelli, B. Biolatti, P. Santi, G. Murialdo, A. Bassi, G. Santori, R. Ciliberti   +6 more
semanticscholar   +1 more source

Confronting the bias towards animal experimentation (animal methods bias)

Frontiers in Drug Discovery
Laws and policies are in place around the world to promote the replacement and reduction of nonhuman animals in science. These principles are rooted not just in ethical considerations for animals, but also in scientific considerations regarding the ...
Catharine E. Krebs, Kathrin Herrmann, Kathrin Herrmann   +2 more
doaj   +1 more source

Prediction of Chemical Respiratory and Contact Sensitizers by OX40L Expression in Dendritic Cells Using a Novel 3D Coculture System

Frontiers in Immunology, 2017
The use of animal models in chemical safety testing will be significantly limited due to the recent introduction of the 3Rs principle of animal experimentation in research.
Izuru Mizoguchi, Mio Ohashi, Yukino Chiba, Hideaki Hasegawa, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto   +6 more
doaj   +1 more source

Rational arguments for regulatory acceptance of consistency testing: benefits of non-animal testing over in vivo release testing of vaccines

Expert Review of Vaccines, 2023
Introduction There are rational arguments to replace existing in vivo potency and safety assays for batch release testing of vaccines with more advanced non-animal techniques to measure critical quality attributes.
Marcel H.N. Hoefnagel, Paul Stickings, Dean Smith, Carmen Jungbäck, Wim Van Molle, Lorenzo Tesolin   +5 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Toxicity testing: the search for an in vitro alternative to animal testing

British Journal of Biomedical Science, 2009
Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to reduce the number of animals used for this purpose due to concerns such as the lack of concordance seen ...
Craig Donaldson, Jinsheng Xu, H. R. Morse, Neil D. Avent, Jennifer E. May   +4 more
openaire   +3 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

An Ontology To Represent Knowledge On Animal Testing Alternatives [PDF]

Nature Precedings, 2009
AbstractEU Directive 86/609/EEC for the protection of laboratory animals obliges scientists to consider whether a planned animal experiment can be replaced, reduced or refined (3Rs principle). To meet this regulatory obligation, scientists must consult the relevant scientific literature prior to any experimental study using laboratory animals.
Michael Schroeder, Andreas Doms, Michael R. Alvers, Barbara Grune, Thomas Wächter, Horst Spielmann, Ursula G. Sauer   +6 more
openaire   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source