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Genetically Modified Animal Organs for Human Transplantation
World Journal of Surgery, 1997AbstractThe major barrier to successful discordant xenogeneic organ transplantation is the phenomenon of hyperacute rejection (HAR). Hyperacute rejection results from the deposition of high‐titer preformed antibodies that activate serum complement on the luminal surface of the vascular endothelium, leading to vessel occlusion and graft failure within ...
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Environmental safety issues for genetically modified animals
Journal of Animal Science, 1993Organisms modified by the techniques of modern biotechnology may differ significantly from normal organisms or organisms modified by other methods. Before transgenic organisms are introduced into the environment, the potential environmental effects should be assessed.
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Experimental animals, 2001
The Biosafety Committee of the Japanese Association of Laboratory Animal Facilities of National Universities (JALAN) investigated recent episodes of microbiological contamination in genetically modified mice (GMM), and the countermeasures taken when the ...
Hiroshi Yamamoto +11 more
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The Biosafety Committee of the Japanese Association of Laboratory Animal Facilities of National Universities (JALAN) investigated recent episodes of microbiological contamination in genetically modified mice (GMM), and the countermeasures taken when the ...
Hiroshi Yamamoto +11 more
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Genetically modified animals in pharmacological research: future trends
European Journal of Pharmacology, 1999The recognition of molecular control elements which govern cell and organ function is essential for the development of novel drug therapies and for an understanding of drug actions. Thus, a major interest is focused on methodologies which permit the identification of novel control elements. This is of particular relevance for the identification of drug
Hanns Möhler +3 more
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Insights into the role of deiodinases from studies of genetically modified animals.
Thyroid, 2005The deiodinases function at a pre-receptor level in tissues to modulate the concentrations, and thus the actions, of thyroid hormones. Although much has been learned in the last two decades about the biochemical properties and expression patterns of ...
D. S. St. Germain +3 more
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Genetically modified animals in molecular stroke research
2004Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a molecular type of injury which leads to delayed or secondary brain injury [15].
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A Menagerie of Moral Hazards: Regulating Genetically Modified Animals
Journal of Law, Medicine & Ethics, 2017Dairy cattle naturally grow long and dangerous horns. So as a protective measure, farmers permanently remove calves' small horns through a painful procedure. Recently, scientists have used modern genetic editing techniques to create dairy cattle that never develop horns, and so never need to be "dehorned".
Sarah Polcz, Anna C. F. Lewis
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Confidence in genetically modified animal research and regulation
Journal für Verbraucherschutz und Lebensmittelsicherheit, 2014Recent advances in animal biotechnology have opened up entirely new opportunities to address and make significant advances for mankind’s most pressing needs: sustainable and efficient food supply to feed a growing population; increasing demands for food safety and quality and new technologies to enhance human health.
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Special issue :Genetically modified animals. Introduction
2009International ...
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