Results 81 to 90 of about 124,540 (297)

Tetralactam-based Anion Transporters

Chem
Synthetic anion transporters provide a promising avenue to treat diseases like cystic fibrosis and cancer. Anion binding site preorganisation is one aspect of transporter design which can be manipulated to enhance binding. Macrocycles possess preorganised binding cavities, enabling more stable, selective, and efficient anion binding and transport.
Alexander Gilchrist, Daniel McNaughton, Mohamed Fares, Xin Wu, Bryson Hawkins, Stephen Butler, David Hibbs, Philip Alan Gale   +7 more
openaire   +1 more source

Towards predictable transmembrane transport: QSAR analysis of anion binding and anion transport [PDF]

, 2013
The transport of anions across biological membranes by small molecules is a growing research field due to the potential therapeutic benefits of these compounds.
Horton, Peter, Herniman, Julie, Bradberry, S. J., Frey, Jeremy G., Costa, Paulo J., Wells, Neil, Gale, Philip A., Wenzel, Marco, Frey, J.G., Bradberry, Samuel J., Karagiannidis, Louise E., Kirby, Isabelle, Felix, Vitor, Light, Mark E., Hiscock, Jennifer R., Herniman, J., Langley, G. John, Marques, Igor, Haynes, Cally J. E., Haynes, Cally, Wells, Neil J., Busschaert, Nathalie, Basschaert, Natalie, Langley, John, Costa, Paulo Jorge, Costa, P.J., Moore, Stephen J., Kirby, Isabelle L., Langley, G. J., Felix, Victor, Horton, Peter N., Marques, I.   +31 more
core   +1 more source

A Simulation Model for the Non-Electrogenic Uniport Carrier-Assisted Transport of Ions across Lipid Membranes

Membranes, 2022
Impressive work has been completed in recent decades on the transmembrane anion transport capability of small synthetic transporters from many different structural classes.
Mariano Andrea Scorciapino, Giacomo Picci, Roberto Quesada, Vito Lippolis, Claudia Caltagirone   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Distal renal tubular acidosis developments in its diagnosis and pathophysiology [PDF]

, 2010
This thesis describes two groups of experiments, both relating to the condition of distal renal tubular acidosis (dRTA). In the first, an alternative diagnostic test of dRTA to the ‘gold standard’ short ammonium chloride (NH4Cl) test was assessed ...
Walsh, S.B.
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Rapid Photodeactivation of Squaramide Chloride Transporters: A Tool for Cytotoxicity Modulation

ChemistryEurope
Cytotoxic anion transporters with light‐regulation properties are highly interesting for the development of anticancer agents with reduced secondary effects.
Bartomeu Galmés, Manel Vega, Fatima Amine, Antonio Costa, Carmen Rotger, Luis Martínez‐Crespo   +5 more
doaj   +1 more source

Mutations conferring SO4 2− pumping ability on the cyanobacterial anion pump rhodopsin and the resultant unique features of the mutant

Scientific Reports, 2022
Membrane transport proteins can be divided into two types: those that bind substrates in a resting state and those that do not. In this study, we demonstrate that these types can be converted by mutations through a study of two cyanobacterial anion ...
Yuhei Doi, Jo Watanabe, Ryota Nii, Takashi Tsukamoto, Makoto Demura, Yuki Sudo, Takashi Kikukawa   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source