Results 61 to 70 of about 2,360,271 (295)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Thiosquaramides: pH switchable anion transporters [PDF]

Chem. Sci., 2014
Thiosquaramides show pH controlled anion transport properties in lipid bilayers.
Busschaert, Nathalie, Elmes, Robert B. P., Czech, Dawid D., Wu, Xin, Kirby, Isabelle L., Peck, Evan M., Hendzel, Kevin D., Shaw, Scott K., Chan, Bun, Smith, Bradley D., Jolliffe, Katrina A., Gale, Philip A.   +11 more
openaire   +7 more sources

Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]

, 2006
Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Role of Mouse Organic Anion Transporter 3 (mOat3) as a Basolateral Prostaglandin E2 Transport Pathway

Journal of Pharmacological Sciences, 2007
Renal organic anion transporters play an important role in the handling of a number of endogenous and exogenous anionic substances in the kidney. In this study, we investigated prostaglandin E2 (PGE2) transport properties and intrarenal localization of ...
Sirinun Nilwarangkoon, Naohiko Anzai, Katsuko Shiraya, Erkang Yu, Rafiqul Islam, Seok Ho Cha, Maristela Lika Onozato, Daisaku Miura, Promsuk Jutabha, Akihiro Tojo, Yoshikatsu Kanai, Hitoshi Endou   +11 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Transzcelluláris bikarbonát szekréció és intracelluláris pH reguláció polarizált epitheliás sejtekben = Transcellular bicarbonate secretion and intracellular pH regulation on polarized epithelial cells [PDF]

, 2009
Kutatásunk célja polarizált epitheliális sejtek elektrolit és folyadékszekréciójának molekuláris szintű vizsgálata volt. Jól differenciált hasnyálmirigy duktusz Capan-1 és HPAF, valamint nyálmirigy acinus ParC10 és SMIE sejtvonalakat vizsgáltunk ...
Burghardt, Beáta
core   +1 more source

Rate Constants for Anion Transport by Steroid-Based Synthetic Anion Transporters [PDF]

Biophysical Journal, 2012
Cholapods are steroid-based synthetic anion transporters that bind anions with high affinity and promote their efflux from liposomes. To understand better the mechanism of action of cholapods, we evaluated the rate constants for anion transport by the cholapods AS09, LJ09 and TL145 using the method developed by Lauger (Science.
Li, Hongyu, Magro, Germinal, Judd, Luke W., Brotherhood, Peter R., Sheppard, David N., Davis, Anthony P.   +5 more
openaire   +1 more source

Monitoring Cl- movement in single cells exposed to hypotonic solution

, 2005
Self-referencing ion--selective electrodes (ISEs), made with Chloride Ionophore I-Cocktail A (Fluka), were positioned 1-3 microm from human embryonic kidney cells (tsA201a) and used to record chloride flux during a sustained hyposmotic challenge. The ISE
Hubert, M., Smith, P.J.S, Messerli, M.A., Indyk, E., Lewis, R., Garber, S.S., Hammar, K.   +6 more
core   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source