The varied functions of the giant muscle scaffold protein obscurin [PDF]
Frontiers in Cell and Developmental BiologyObscurin is a giant protein encoded by the OBSCN gene in human myocytes, known for its roles in sarcomere organization, elasticity, stretch response, and myofibrillogenesis.
James Novac Di Paola, Frieder Schöck
doaj +2 more sources
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells [PDF]
Molecular Therapy: Methods & Clinical Development, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene. Despite the inclusion of these elements, the efficacy of
Zulema Romero +12 more
doaj +6 more sources
Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53 [PDF]
Virology Journal, 2011 Background The carboxyl terminal of Epstein-Barr virus (EBV) ZEBRA protein (also termed BZLF-1 encoded replication protein Zta or ZEBRA) binds to both NF-κB and p53. The authors have previously suggested that this interaction results from an ankyrin-like
Ghoda Lucy Y +3 more
doaj +2 more sources
Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]
BiomoleculesThe axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu +4 more
doaj +2 more sources
Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. [PDF]
, 2015 Skeletal muscle is the major site for glucose disposal, the impairment of which closely associates with the glucose intolerance in diabetic patients. Diabetes-related ankyrin repeat protein (DARP/Ankrd23) is a member of muscle ankyrin repeat proteins ...
Chen, Ju +10 more
core +5 more sources
Viruses, 2022 A designed repeat scaffold protein (AnkGAG1D4) recognizing the human immunodeficiency virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we investigated the molecular mechanism of AnkGAG1D4 function during the late stages
Sutpirat Moonmuang +6 more
doaj +1 more source
Frontiers in Physiology, 2023 Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons.
Julie P. Gupta +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan +2 more
doaj +1 more source
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A
eLife, 2021 Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms.
Blake A Creighton +12 more
doaj +1 more source
Severe hereditary spherocytosis presenting with non-immune fetal hydrops
Indian Pediatrics Case Reports, 2023 Background: Hereditary spherocytosis (HS) is characterized by spherocytes on the peripheral smear and heterogeneous clinical presentation (mild, moderate, moderate/severe, and severe) depending upon the severity of hemolytic anemia, jaundice, and ...
Snehal Mallakmir +3 more
doaj +1 more source