Results 211 to 220 of about 9,634,082 (235)

Cholinergic Augmentation of Insulin Release Requires Ankyrin-B

Science Signaling, 2010
The scaffolding protein ankyrin-B is needed for maximal insulin release, and loss of function is a risk factor for diabetes.
Jane A, Healy, Kent R, Nilsson, Hans E, Hohmeier, Jelena, Berglund, Jonathan, Davis, Janis, Hoffman, Martin, Kohler, Luo-Sheng, Li, Per-Olof, Berggren, Christopher B, Newgard, Vann, Bennett   +10 more
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Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development

Neuron, 2020
Variants in the ANK3 gene encoding ankyrin-G are associated with neurodevelopmental disorders, including intellectual disability, autism, schizophrenia, and bipolar disorder. However, no upstream regulators of ankyrin-G at synapses are known.
Sehyoun Yoon, Euan Parnell, Maria Kasherman   +2 more
exaly   +3 more sources

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119-OR: Ankyrin-B Modulates Lipid Metabolism in Brown Adipocytes

Diabetes, 2021
Human variants in the membrane adaptor ankyrin-B (AnkB) present at frequencies from 0.05 to 7% across different ethnicities have been linked to obesity and type 2 diabetes (T2D). We reported that knock-in mice bearing T2D-linked human AnkB variants develop age- or diet-dependent obesity and insulin resistance (IR).
ASHLEY AGUILLARD, JOYCE TZENG, DAMARIS LORENZO   +2 more
openaire   +1 more source

Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons

Brain Structure and Function, 2012
Axons are subdivided into functionally organized microdomains, which are required for generation and propagation of action potentials (APs). In the central nervous system (CNS), APs are generated near the soma in the axon initial segment (AIS) and propagated by nodes of Ranvier (noR).
Maren, Engelhardt, Silke, Vorwald, Jürgen-Markus, Sobotzik, Vann, Bennett, Christian, Schultz   +4 more
openaire   +2 more sources

Regulation of Pancreatic Beta Cell Function by Ankyrin‐B

The FASEB Journal, 2017
Functional variants of the cytoskeletal protein ankyrin‐B (AnkB) have been implicated in human hereditary cardiac arrhythmia and type 2 diabetes (T2D).1–3 We recently showed that knock‐in mice expressing human AnkB variants p.R1788W (present in 0.2% Caucasians and associated with T2D) or p.L1622I (present in 7.5% of African ...
Damaris N Lorenzo, Janell Hostettler, Vann Bennett   +2 more
openaire   +1 more source

Inhibition of Ankyrin-B Expression Reduces Growth and Invasion of Human Pancreatic Ductal Adenocarcinoma

Pancreatology, 2010
In spite of the increasing knowledge of the molecular pathology of pancreatic ductal adenocarcinoma (PDAC), treatment of this tumor still remains an unresolved problem. Thus, the identification of 'novel' genes involved in pancreatic tumor progression is essential for early diagnosis and new treatment regimens of PDAC.
Ying, Chen, Matthias, Löhr, Ralf, Jesnowski   +2 more
openaire   +2 more sources

Mechanistic studies of ankyrin-B/ankyrin-G autoinhibition and regulation

2015
Ankyrins are a family of scaffold proteins, which serves to link great varieties of functional related but structurally diverse integral membrane proteins to the spectrin-based cytoskeletons. In vertebrates, the Ankyrin family consists of three members: ankyrin-R (AnkR), ankyrin-B (AnkB) and ankyrin-G (AnkG), encoded by ANK1, ANK2 and ANK3 ...
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Analysis of ankyrin-B gene mutations in patients with long QT syndrome.

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008
To identify the ankyrin-B gene mutations that cause long QT syndrome (LQTS) and determine the prevalence of such mutations in Japanese patients with LQTS.We conducted a search for ankyrin-B gene mutation in 78 unrelated patients with LQTS (28 males and 50 females, aged 2 to 89 years).
Xiang, Zhou, Masami, Shimizu, Tetsuo, Konno, Hidekazu, Ino, Noboru, Fujino, Katsuharu, Uchiyama, Tomohito, Mabuchi, Tomoya, Kaneda, Takashi, Fujita, Ei-ichi, Masuda, Hiromasa, Kato, Akira, Funada, Hiroshi, Mabuchi   +12 more
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Sequence and Structure-Based Analyses of Human Ankyrin Repeats

Molecules, 2022
Broto Chakrabarty, Nita Parekh, Parekh Nita   +2 more
exaly  

Identification of novel intracellular mechanisms in developmental spine pruning through Ankyrin B.

2019
Dendritic spines are the predominant site of glutamatergic inputs throughout the brain. Regulation of spines is therefore critical for refining cortical networks. This research sought to define mechanisms for determining spine fate during developmental synapse remodeling.
openaire   +1 more source