Results 181 to 190 of about 42,034 (274)

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

Non-superagonist CD28-based dual-signal T cell engager targeting. [PDF]

J Immunother Cancer
Chen T, Wang Y, Chen X, Li Y, Guo J, Liu F, Shao J, Yan J, Li M, Nie J, Sun Q, Liu Q, Liu B.   +12 more
europepmc   +1 more source

NF-κB regulates neuronal ankyrin-G via a negative feedback loop.

, 2017
The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation ...
Jochen Prehn (7895672), Hans-Georg König (5168390), Sinéad Kinsella (5168381), Robert Schwamborn (7955165), Orla Watters (5168387), Beau Fenner (7955171), Silke Andresen (7955168)   +6 more
core  

Effects of Different SNP Calling and Sequence Mapping Choices on the Inference of Genetic Architecture Underlying Migration Tendency

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We re‐analysed RAD‐Seq data from brown trout using a conspecific reference genome and alternative SNP pipelines. Population structure was robust across methods, but using the brown trout reference improved detection of biologically relevant outlier SNPs. ABSTRACT Genome‐wide association studies with identification of biologically relevant genes rely on
Giovanna Mottola, Frank Panitz, Tuomas Leinonen, Alexandre Lemopoulos, Anssi Vainikka   +4 more
wiley   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia-Associated Behaviours in Mice. [PDF]

J Neurochem
Brum ES, Fialho MFP, de Araújo DSM, Landini L, Marini M, De Logu F, Nassini R, Oliveira SM.   +7 more
europepmc   +1 more source

Ankyrin Mutations in Hereditary Spherocytosis [PDF]

Acta Haematologica, 2019
openaire   +2 more sources

A non-canonical ARMS-GABARAP interaction modulates dendritic spine formation and synaptic development. [PDF]

EMBO J
Jiang W, Ye J, Chen J, Wang X, Li Y, Li J, Mei Y, Lyu Y, Hu W, Wang C.   +9 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment. [PDF]

Proc Natl Acad Sci U S A
Lopez AY, Jenkins PM.
europepmc   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source