Results 11 to 20 of about 68,407 (296)
Poxviral Ankyrin Proteins [PDF]
Viruses, 2015 Multiple repeats of the ankyrin motif (ANK) are ubiquitous throughout the kingdoms of life but are absent from most viruses. The main exception to this is the poxvirus family, and specifically the chordopoxviruses, with ANK repeat proteins present in all
Michael H. Herbert +2 more
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The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells [PDF]
Molecular Therapy: Methods & Clinical Development, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene. Despite the inclusion of these elements, the efficacy of
Zulema Romero +12 more
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Ankyrin‐2 genetic variants: A case of Ankyrin‐B syndrome [PDF]
Annals of Noninvasive Electrocardiology, 2022 Inherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin‐B or ankyrin‐2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to
Jin Song +2 more
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Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels [PDF]
Molecular Brain, 2019 Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epilepsy and autism spectrum disorder, but ...
Catherine S. W. Choi +5 more
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FEBS Letters, 2000 This review is focused on ankyrin which is a protein linker between the integral membrane proteins and spectrin‐based cytoskeleton. Structure and distribution of different ankyrin isoforms that are products of alternative‐spliced genes are described. Interaction of ankyrins with various membranes is considered.
Rubtsov, Alexander M, Lopina, Olga D
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eLife, 2021 Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in
Sharon R Stevens +10 more
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LQT4 Gene: The "Missing" Ankyrin [PDF]
Molecular Interventions, 2003 Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and the functions of several channels and pumps that normally interact with wild-type ankyrin-B are impaired in the ...
Sandro L. Yong
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Applied Sciences, 2020 Among the several tetratricopeptide (TPR) repeat-containing proteins encoded by the Arabidopsis thaliana genome, AtTPR10 exhibits an atypical structure with three TPR domain repeats at the C-terminus in addition to seven ankyrin (ANK) domain repeats at ...
Seol Ki Paeng +9 more
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Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis [PDF]
Science Advances, 2015 Paul Jenkins, Vann Bennett
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