Functional dynamics of the folded ankyrin repeats of I kappa B alpha revealed by nuclear magnetic resonance. [PDF]
, 2009 Inhibition of nuclear factor kappaB (NF-kappaB) is mainly accomplished by IkappaB alpha, which consists of a signal response sequence at the N-terminus, a six-ankyrin repeat domain (ARD) that binds NF-kappaB, and a C-terminal PEST sequence.
Cervantes, Carla F +5 more
core +3 more sources
Mechanical Anisotropy of Ankyrin Repeats [PDF]
Biophysical Journal, 2012 Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W +7 more
openaire +3 more sources
The Wolbachia Genome of Brugia malayi: Endosymbiont Evolution within a Human Pathogenic Nematode [PDF]
, 2005 Complete genome DNA sequence and analysis is presented for Wolbachia, the obligate alpha-proteobacterial endosymbiont required for fertility and survival of the human filarial parasitic nematode Brugia malayi. Although, quantitatively, the genome is even
+204 more
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Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. [PDF]
, 2013 International audienceSalmonella, a ubiquitous Gram-negative intracellular bacterium, is a food borne pathogen that infects a broad range of hosts.
Canonne-Hergaux, François +9 more
core +6 more sources
Deletion of small ankyrin 1 (SANK1) isoforms results in structural and functional alterations in aging skeletal muscle fibers [PDF]
, 2015 Muscle-specific ankyrins 1 (sAnk1) are a group of small ankyrin 1 isoforms, of which sAnk1.5 is the most abundant. sAnk1 are localized in the sarcoplasmic reticulum (SR) membrane from where they interact with obscurin, a myofibrillar protein.
Birkenmeier, C. +14 more
core +1 more source
Protein Repeats from First Principles [PDF]
, 2016 Some natural proteins display recurrent structural patterns. Despite being highly similar at the tertiary structure level, repeating patterns within a single repeat protein can be extremely variable at the sequence level. We use a mathematical definition
Becher, Veronica Andrea +4 more
core +1 more source
Axonal Spectrins: Nanoscale Organization, Functional Domains and Spectrinopathies
Frontiers in Cellular Neuroscience, 2019 Spectrin cytoskeletons are found in all metazoan cells, and their physical interactions between actin and ankyrins establish a meshwork that provides cellular structural integrity.
Cheng-Hsin Liu +2 more
doaj +1 more source
Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure [PDF]
, 2019 Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest 1352 healthy and failing human hearts directly from transplant center operating rooms, and ...
Ashley, Euan A. +34 more
core +2 more sources
LQT4 Gene: The "Missing" Ankyrin [PDF]
Molecular Interventions, 2003 Mutations in ion channels have been implicated in the formation of long QT syndrome (LQTS). However, Mohler et al. have recently uncovered a role for ankyrin-B, a non-ion channel protein, in type IV LQTS. Calcium signalling is altered, and the functions of several channels and pumps that normally interact with wild-type ankyrin-B are impaired in the ...
Sandro, Yong, Xiaoli, Tian, Qing, Wang
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Nanospring behaviour of ankyrin repeats [PDF]
Nature, 2006 Ankyrin repeats are an amino-acid motif believed to function in protein recognition; they are present in tandem copies in diverse proteins in nearly all phyla. Ankyrin repeats contain antiparallel alpha-helices that can stack to form a superhelical spiral. Visual inspection of the extrapolated structure of 24 ankyrin-R repeats indicates the possibility
Gwangrog, Lee +5 more
openaire +2 more sources