Results 41 to 50 of about 2,738 (207)

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]

, 2012
Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju, Lange, Stephan, Perera, Sue, Teh, Phildrich   +3 more
core   +2 more sources

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels [PDF]

Molecular Brain, 2019
Abstract Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epilepsy and autism spectrum disorder, but understanding of the underlying mechanisms is limited.
Catherine S. W. Choi, Ivana A. Souza, Juan C. Sanchez-Arias, Gerald W. Zamponi, Laura T. Arbour, Leigh Anne Swayne   +5 more
openaire   +5 more sources

Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intramuscular fat content

BMC Genetics, 2010
Background Recent QTL and gene expression studies have highlighted ankyrins as positional and functional candidate genes for meat quality. Our objective was to characterise the promoter region of the bovine ankyrin 1 gene and to test polymorphisms for ...
Sweeney Torres, Aslan Ozlem, Mullen Anne, Hamill Ruth M   +3 more
doaj   +1 more source

Dysfunction in the βII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia. [PDF]

, 2015
Background: The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked with cardiac pathologies including myopathies ...
Bhakta, Deepak, Binkley, Philip F., Bonilla, Ingrid M., Carnes, Cynthia A., Curran, Jerry, Dobrev, Dobromir, Higgins, Robert S., Hughes, Langston D., Hund, Thomas J., Janssen, Paul M., Kilic, Ahmet, Kline, Crystal F., Little, Sean C., Long, Victor P., Ma, Jianjie, Makara, Michael, Mohler, Peter J., Polina, Iuliia, Rasband, Matthew N., Smith, Sakima A., Spoonamore, Katherine G., Sturm, Amy C., Sun, Mingzhai, Vatta, Matteo, Voigt, Niels, Webb, Tyler R., Wei, Zhiyi, Weiss, Raul, Wright, Patrick, Zhang, Chuansheng, Zhang, Mingjie   +30 more
core   +1 more source

Evolution and comparative genomics of the most common Trichoderma species

BMC Genomics, 2019
Background The growing importance of the ubiquitous fungal genus Trichoderma (Hypocreales, Ascomycota) requires understanding of its biology and evolution. Many Trichoderma species are used as biofertilizers and biofungicides and T.
Christian P. Kubicek, Andrei S. Steindorff, Komal Chenthamara, Gelsomina Manganiello, Bernard Henrissat, Jian Zhang, Feng Cai, Alexey G. Kopchinskiy, Eva M. Kubicek, Alan Kuo, Riccardo Baroncelli, Sabrina Sarrocco, Eliane Ferreira Noronha, Giovanni Vannacci, Qirong Shen, Igor V. Grigoriev, Irina S. Druzhinina   +16 more
doaj   +1 more source

Tissue-specific Expression of Distinct Spectrin and Ankyrin Transcripts in Erythroid and Nonerythroid Cells [PDF]

, 1985
cDNA probes for three components of the erythroid membrane skeleton, α spectrin, β spectrin, and ankyrin, were obtained by using monospecific antibodies to screen a λgt11 expression vector library containing cDNA prepared from chicken erythroid poly(A)^+
Lazarides, Elias, Moon, Randall T., Ngai, John, Wold, Barbara J.   +3 more
core   +3 more sources

Obscurins: Goliaths and Davids take over non-muscle tissues.

PLoS ONE, 2014
Obscurins comprise a family of proteins originally identified in striated muscles, where they play essential roles in myofibrillogenesis, cytoskeletal organization, and Ca(2+) homeostasis.
Maegen A Ackermann, Marey Shriver, Nicole A Perry, Li-Yen R Hu, Aikaterini Kontrogianni-Konstantopoulos   +4 more
doaj   +1 more source

Advances in the design and engineering of peptide-binding repeat proteins [PDF]

, 2017
The specific recognition of peptides, which we define to include unstructured regions or denatured forms of proteins, is an intrinsic part of a multitude of biochemical assays and procedures. Many cellular interactions are also based on this principle as
Ernst, Patrick, Plückthun, Andreas
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier

Frontiers in Cellular Neuroscience, 2017
Neurons are highly specialized cells of the nervous system that receive, process and transmit electrical signals critical for normal brain function.
Andrew D. Nelson, Paul M. Jenkins, Paul M. Jenkins   +2 more
doaj   +1 more source