Results 41 to 50 of about 2,806 (200)

Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]

, 2014
BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A, Clarke, Thomas H, Garb, Jessica E, Haney, Robert A, Hayashi, Cheryl Y   +4 more
core   +2 more sources

The multifunctional polydnavirus TnBVANK1 protein: impact on host apoptotic pathway [PDF]

, 2017
Toxoneuron nigriceps (Hymenoptera, Braconidae) is an endophagous parasitoid of the larval stages of the tobacco budworm, Heliothis virescens (Lepidoptera, Noctuidae). The bracovirus associated with this wasp (TnBV) is currently being studied.
Amoresano, A, Bufo, Sa, Carmosino, M, Falabella, P, Giangrande, C, Grossi, G, Laurenzana, I, Nardiello, M, Neunemann, D, Pucci, P, Ruggieri, V, Salvia, R, Scieuzo, C, Vinson, Sb, Vogel, H   +14 more
core   +3 more sources

Dysfunction in the βII Spectrin-Dependent Cytoskeleton Underlies Human Arrhythmia. [PDF]

, 2015
Background: The cardiac cytoskeleton plays key roles in maintaining myocyte structural integrity in health and disease. In fact, human mutations in cardiac cytoskeletal elements are tightly linked with cardiac pathologies including myopathies ...
Bhakta, Deepak, Binkley, Philip F., Bonilla, Ingrid M., Carnes, Cynthia A., Curran, Jerry, Dobrev, Dobromir, Higgins, Robert S., Hughes, Langston D., Hund, Thomas J., Janssen, Paul M., Kilic, Ahmet, Kline, Crystal F., Little, Sean C., Long, Victor P., Ma, Jianjie, Makara, Michael, Mohler, Peter J., Polina, Iuliia, Rasband, Matthew N., Smith, Sakima A., Spoonamore, Katherine G., Sturm, Amy C., Sun, Mingzhai, Vatta, Matteo, Voigt, Niels, Webb, Tyler R., Wei, Zhiyi, Weiss, Raul, Wright, Patrick, Zhang, Chuansheng, Zhang, Mingjie   +30 more
core   +1 more source

Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels [PDF]

Molecular Brain, 2019
Abstract Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epilepsy and autism spectrum disorder, but understanding of the underlying mechanisms is limited.
Catherine S. W. Choi, Ivana A. Souza, Juan C. Sanchez-Arias, Gerald W. Zamponi, Laura T. Arbour, Leigh Anne Swayne   +5 more
openaire   +5 more sources

Regulatory polymorphisms in the bovine Ankyrin 1 gene promoter are associated with tenderness and intramuscular fat content

BMC Genetics, 2010
Background Recent QTL and gene expression studies have highlighted ankyrins as positional and functional candidate genes for meat quality. Our objective was to characterise the promoter region of the bovine ankyrin 1 gene and to test polymorphisms for ...
Sweeney Torres, Aslan Ozlem, Mullen Anne, Hamill Ruth M   +3 more
doaj   +1 more source

Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. [PDF]

, 2012
Protein turnover through cullin-3 is tightly regulated by posttranslational modifications, the COP9 signalosome, and BTB/POZ-domain proteins that link cullin-3 to specific substrates for ubiquitylation.
Chen, Ju, Lange, Stephan, Perera, Sue, Teh, Phildrich   +3 more
core   +2 more sources

Evolution and comparative genomics of the most common Trichoderma species

BMC Genomics, 2019
Background The growing importance of the ubiquitous fungal genus Trichoderma (Hypocreales, Ascomycota) requires understanding of its biology and evolution. Many Trichoderma species are used as biofertilizers and biofungicides and T.
Christian P. Kubicek, Andrei S. Steindorff, Komal Chenthamara, Gelsomina Manganiello, Bernard Henrissat, Jian Zhang, Feng Cai, Alexey G. Kopchinskiy, Eva M. Kubicek, Alan Kuo, Riccardo Baroncelli, Sabrina Sarrocco, Eliane Ferreira Noronha, Giovanni Vannacci, Qirong Shen, Igor V. Grigoriev, Irina S. Druzhinina   +16 more
doaj   +1 more source

Obscurins: Goliaths and Davids take over non-muscle tissues.

PLoS ONE, 2014
Obscurins comprise a family of proteins originally identified in striated muscles, where they play essential roles in myofibrillogenesis, cytoskeletal organization, and Ca(2+) homeostasis.
Maegen A Ackermann, Marey Shriver, Nicole A Perry, Li-Yen R Hu, Aikaterini Kontrogianni-Konstantopoulos   +4 more
doaj   +1 more source

The Exposed Proteomes of Brachyspira hyodysenteriae and B. pilosicoli [PDF]

, 2016
Brachyspira hyodysenteriae y Brachyspira pilosicoli son bien conocidos como patógenos intestinales en cerdos. B. Hyodysenteriae es el agente causal de la disentería porcina, una enfermedad con un importante impacto en la producción de porcino, mientras ...
Vanessa Casas, Santiago Vadillo, Carlos San Juan, Montserrat Carrascal, Joaquin Abian   +4 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source