Results 121 to 130 of about 34,339 (250)

Inhibition of HMGA2 Leads to Reduced Cell Proliferation and Increased Apoptosis in Human Embryonal Carcinoma Cell Lines

Andrology, EarlyView.
ABSTRACT Background The most prevalent solid tumors in young men are testicular germ cell tumors (TGCTs), and embryonal carcinoma is the most common subtype among non‐seminomatous germ cell tumors (NSGCTs). Despite the excellent cure rates of cisplatin‐based chemotherapy, resistance develops in 15%–30% of patients with metastatic cancer, which results ...
Marco De Martino, Matteo Lampitto, Alfredo Fusco, Marco Barchi, Francesco Esposito, Paolo Chieffi   +5 more
wiley   +1 more source

Endocytosis Occurs Independently Of Annexin-Vi In Human A431 Cells [PDF]

, 1994
Annexin VI is one of a family of calcium-dependent phospholipid-binding proteins. Although the function of this protein is not known, various physiological roles have been proposed, including a role in the budding of clathrin-coated pits (Lin et al ...
Jacob, S., Moss, S., Smith, P., Smythe, E., Theobald, J.   +4 more
core   +2 more sources

Transmembrane Protein GbTMEM209 Inhibits Fibre Elongation via Competitive Interaction With GbHOX3 in Gossypium barbadense

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sea Island cotton (Gossypium barbadense) produces premium‐quality fibres, yet the genetic basis underlying its fibre development remains elusive. Here, we identify two key non‐synonymous single nucleotide polymorphisms (SNPs, G/C and G/A) in the gene Gbar_D13G024080, which encodes the TRANSMEMBRANE PROTEIN 209 (TMEM209). These SNPs resulted in
Kaiyun Jiang, Nan Zhao, Jie Kong, Anhui Guo, Yuqi Liu, Meng Wang, Zixin Zhou, Mengling Sun, Weiran Wang, Jiahui Zhu, Daojun Yuan, Zhuanxia Pan, Pengbo Li, Suen Liu, Baosheng Guo, Huijing Li, Jingrou Zhang, Bin Li, Zhanghao Xia, Beibei Lv, Junyi Geng, Baoliang Wang, Alifu Aierxi, Xianlong Zhang, Lili Tu, Jinping Hua   +25 more
wiley   +1 more source

Tumour antigen expression in hepatocellular carcinoma in a low-endemic western area [PDF]

, 2015
Background: Identification of tumour antigens is crucial for the development of vaccination strategies against hepatocellular carcinoma (HCC). Most studies come from eastern-Asia, where hepatitis-B is the main cause of HCC.
A Ferrandez-Izquierdo, A Fujimoto, A Jemal, A Liu, AA Jungbluth, B Li, B Yan, BG Peng, C Brumm, C Landry, C Langner, C Liu, C Verhoef, CC Wang, CD Witjes, CH Chen, D Sprengers, DJ Brennan, DS Yee, DW Ho, E Schultz-Thater, E Yakaboski, F Monma, G Luo, GK Abou-Alfa, GR Yu, GY Chau, H Shirakawa, HA Vaughan, HB El-Serag, HB El-Serag, HM Lacy, HS Mohammad, I Mellman, J Filmus, J Frayne, J Kwekkeboom, J Liang, J N M IJzermans, JF Perz, JM Lang, JM Llovet, JR Peng, K Biermann, K Sideras, K Yorita, KJ Yong, KJ Yong, L Zheng, LQ Wu, M Deguchi, M J Bruno, M Kuang, M Tsuji, MA Cheever, MI Minervini, MO Riener, N Koide, NR dos Santos, O Hofmann, P Ganjei, P Kvistborg, P Li, P Zhao, PW Kantoff, PW Kantoff, Q Pan, QY Xia, R A de Man, R Kannangai, R Zhuang, S J Bots, S Nakamura, S Nakatsuka, S Sleijfer, SK Lau, SS Zeng, T Longerich, T Oikawa, T Sera, V Gerke, V Scharnhorst, W G Polak, W Zou, WC Lee, WJ Ma, WW Zhu, X Zhang, Y Cao, Y Sawada, Z Liu   +90 more
core   +5 more sources

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting

Scientific Reports, 2017
Cytoskeletal-associated proteins play an active role in coordinating the adhesion and migration machinery in cancer progression. To identify functional protein networks and potential inhibitors, we screened an internalizing phage (iPhage) display library
Daniela I. Staquicini, Roberto Rangel, Liliana Guzman-Rojas, Fernanda I. Staquicini, Andrey S. Dobroff, Christy A. Tarleton, Michelle A. Ozbun, Mikhail G. Kolonin, Juri G. Gelovani, Serena Marchiò, Richard L. Sidman, Katherine A. Hajjar, Wadih Arap, Renata Pasqualini   +13 more
doaj   +1 more source

Clofazimine Induced Suicidal Death of Human Erythrocytes

Cellular Physiology and Biochemistry, 2015
Background/Aims: The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis.
Arbace Officioso, Kousi Alzoubi, Caterina Manna, Florian Lang   +3 more
doaj   +1 more source

Oculomotor Nucleus [PDF]

, 2008
This report contains a gene expression summary of the oculomotor nucleus, derived from the Allen Brain Atlas (ABA) in situ hybridization mouse data set.
Allen Institute for Brain Science, Angela L. Guillozet-Bongaarts, Josh J. Burnell, Lydia L. Ng   +3 more
core   +2 more sources

Synthesis, Characterization, and Biological Evaluation of Aliphatic‐Substituted Benzimidazole Derivatives: Induction of Apoptosis, Cell Cycle Arrest, and Molecular Docking in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A new series of aliphatic‐substituted benzimidazole derivatives was synthesized and structurally characterized to evaluate their potential anticancer activity. Among the synthesized compounds, compound 4 exhibited the most potent cytotoxic effects against MCF‐7 and MDA‐MB‐231 breast cancer cell lines, with IC₅₀ values comparable to those of ...
Murat Keser, Çisil Çamlı Pulat, Harika Atmaca, Hakan Akgün, Canan Albay, Emre Menteşe, Hakan Bektaş, Suleyman Ilhan   +7 more
wiley   +1 more source

Chronic myelogenous leukaemia exosomes modulate bone marrow microenvironment through activation of epidermal growth factor receptor [PDF]

, 2016
Chronic myelogenous leukaemia (CML) is a clonal myeloproliferative disorder. Recent evidence indicates that altered crosstalk between CML and mesenchymal stromal cells may affect leukaemia survival; moreover, vesicles released by both tumour and non ...
Alessandro, R., Corrado, C, De Leo, G, Raimondo, S, Saieva, L, Santoro, A   +5 more
core   +1 more source