Results 71 to 80 of about 34,339 (250)

Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis [PDF]

, 2016
TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases.
Barrios, Bibiana Elisabet, Correa, Silvia Graciela, De Paula Silva, Marina, Maccio Maretto, Lisa, Oliani, Sonia María, Poliselli Farsky, Sandra Helena, Sena, Angela   +6 more
core   +1 more source

Annexin A2 and S100A10 in the mammalian oviduct [PDF]

Cell and Tissue Research, 2015
In many mammals, upon entry into the female reproductive tract, a subpopulation of sperm is stored in the oviduct forming a functional reservoir. In the oviducts of pig and cow, Annexin A2 (AnxA2) has been linked to the binding of sperm. This protein may exist as a monomer or bound to S100A10 and both forms are associated with different biological ...
Teijeiro, Juan Manuel, Roldán, María Lorena, Marini, Patricia Estela   +2 more
openaire   +5 more sources

Engineering Extracellular Vesicle Production Through Magnetic Ion Channel Activation for Bone Regeneration

Advanced Healthcare Materials, EarlyView.
Magnetic Ion Channel Activation (MICA) enables remote stimulation of mechanosensitive ion channels using functionalised magnetic nanoparticles, enhancing extracellular vesicle (EV) biogenesis is pre‐osteoblasts. MICA desrived EVs exhibit typical nano‐vesicular characteristics but display superior pro‐osteogeneic activity, promoting mesenchymal stem ...
Afeesh Rajan Unnithan, Kenny Man, Kritika, Lee A. Gethings, Christopher J. Hughes, Alicia Keenan, Liam Heaney, Sophie C. Cox, Owen G. Davies, Alicia J. El Haj   +9 more
wiley   +1 more source

Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction

Parasites & Vectors, 2015
Background Invasion of host cells by Trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. However, the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated.
Thaise Lara Teixeira, Lilian Cruz, Renato Arruda Mortara, Claudio Vieira Da Silva   +3 more
doaj   +1 more source

Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway

Parasites & Vectors, 2020
Background Angiostrongylus cantonensis can cause severe symptoms of central nervous system infections. In the host, this parasite localizes in the blood and cerebrospinal fluid, and its secreted components can impact immune responses.
Xiaomeng Shi, Mengran Xiao, Zhiyue Xie, Qing Shi, Yuanjiao Zhang, Jianmei W. Leavenworth, Baolong Yan, Huicong Huang   +7 more
doaj   +1 more source

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. [PDF]

PLoS ONE, 2011
Fluid flow through large interstitial spaces is sensed at the cellular level, and mechanistic responses to flow changes enables expansion or contraction of the cells modulating the surrounding area and brings about changes in fluid flow.
Manik Goel, Adam E Sienkiewicz, Renata Picciani, Richard K Lee, Sanjoy K Bhattacharya   +4 more
doaj   +1 more source

Expression of annexin A2 in adenomyosis and dysmenorrhea [PDF]

Archives of Gynecology and Obstetrics, 2019
To investigate the expression of annexin A2 (ANXA2) in ectopic and eutopic endometrium and serum of women with adenomyosis, and their relationships with adenomyosis-associated dysmenorrhea.The expression of ANXA2 was detected by immunohistochemical S-P method in ectopic and eutopic endometrium tissues from 30 patients with adenomyosis who underwent ...
Feng Liu, Lixue Liu, Jian Zheng
openaire   +2 more sources

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Inside-out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles [PDF]

, 2016
This is the author accepted manuscript. The final version is available from Science Matters via https://www.sciencematters.io/articles/201602000015Inside-out: unpredicted Annexin A2 localisation on the surface of extracellular vesicles Extracellular ...
Gessler, Florian, Moreau, Kevin, Pluchino, Stefano, Stewart, Sarah   +3 more
core   +3 more sources