Results 141 to 150 of about 2,972 (170)

Functional roles of interstitial cells of Cajal in the GI tract of rats. [PDF]

open access: yesAm J Physiol Gastrointest Liver Physiol
Hwang SJ   +6 more
europepmc   +1 more source

A Cftr-independent, Ano1-rich seawater-adaptive ionocyte in sea lamprey gills.

open access: yesJ Exp Biol
Shaughnessy CA   +8 more
europepmc   +1 more source
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Role of ANO1 in tumors and tumor immunity

Journal of Cancer Research and Clinical Oncology, 2022
Dysregulation of gene amplification, cell-signaling-pathway transduction, epigenetic and transcriptional regulation, and protein interactions drives tumor-cell proliferation and invasion, while ion channels also play an important role in the generation and development of tumor cells.
Xueguo Sun, Zongtao Liu
exaly   +3 more sources

Involvement of TMEM16A/ANO1 upregulation in the oncogenesis of colorectal cancer

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2022
The Ca2+-activated Cl- channel ANO1 is widely expressed in epithelial cells, and ANO1 upregulation is implicated in the oncogenesis of many epithelium-originated cancers. However, whether ANO1 plays a causal role in the tumorigenesis of colorectal cancer remains largely unknown. Here, we show that ANO1 channel protein is upregulated in human colorectal
Chunhua Han, Zongtao Liu, Yani Liu
exaly   +3 more sources

TMEM16A (ANO1) as a therapeutic target in cystic fibrosis

Current Opinion in Pharmacology, 2022
Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface and to allow efficient mucociliary clearance.
openaire   +3 more sources

Regulation of ANO1/TMEM16A anion permeability

Pancreatology, 2013
Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung   +5 more
openaire   +1 more source

Understanding the Role of ANO1 in Oral Cancer

2021
In 2008, the gene ANO1 was discovered to encode a calcium activated chloride channel. This gene is located on the 11q13 locus, a locus that is commonly amplified in many cancers including cancer of the head and neck. ANO1 is situated in close proximity to genes associated with growth and apoptosis.
openaire   +1 more source

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