Results 141 to 150 of about 2,978 (169)

Role of ANO1 in tumors and tumor immunity

Journal of Cancer Research and Clinical Oncology, 2022
Dysregulation of gene amplification, cell-signaling-pathway transduction, epigenetic and transcriptional regulation, and protein interactions drives tumor-cell proliferation and invasion, while ion channels also play an important role in the generation and development of tumor cells.
Zong-Tao Liu
exaly   +3 more sources

Investigating the regulatory function of the ANO1-AS2 on the ANO1 gene in infertile men with asthenozoospermia and terato-asthenozoospermia

Experimental and Molecular Pathology, 2020
Long non-coding RNAs (lncRNAs) have a particular expression in the testicular tissue and exhibit a regulatory function on the reproduction system. ANO1-AS2 (linc02584), as an lncRNA is located near the anoctamin1 (ANO1) gene. ANO1 is an important component of the transmembrane system exhibiting expression modifications in the idiopathic infertile men ...
Mohammadreza Saberiyan, Hossein Teimori, Leila Dehdehi   +2 more
exaly   +3 more sources

Involvement of TMEM16A/ANO1 upregulation in the oncogenesis of colorectal cancer

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2022
The Ca2+-activated Cl- channel ANO1 is widely expressed in epithelial cells, and ANO1 upregulation is implicated in the oncogenesis of many epithelium-originated cancers. However, whether ANO1 plays a causal role in the tumorigenesis of colorectal cancer remains largely unknown. Here, we show that ANO1 channel protein is upregulated in human colorectal
Kewei Wang, Zong-Tao Liu, Yani Liu
exaly   +3 more sources

TMEM16A (ANO1) as a therapeutic target in cystic fibrosis

Current Opinion in Pharmacology, 2022
Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface and to allow efficient mucociliary clearance.
openaire   +3 more sources

Transcriptional activation of ANO1 promotes gastric cancer progression

Biochemical and Biophysical Research Communications, 2019
The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. The GC-related molecular mechanisms underlying invasion and metastasis are not well understood. In this study, we investigated the functional role of ANO1 in GC progression.
Duyi Pan, Shiyao Chen, Hao Wu
exaly   +3 more sources

Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1 [PDF]

International Journal of Molecular Sciences, 2019
Receptor-type ion channels are critical for detection of noxious stimuli in primary sensory neurons. Transient receptor potential (TRP) channels mediate pain sensations and promote a variety of neuronal signals that elicit secondary neural functions (such as calcitonin gene-related peptide [CGRP] secretion), which are important for physiological ...
Sandra Derouiche, Makoto Tominaga, Kenta Maruyama   +2 more
exaly   +3 more sources

Understanding the Role of ANO1 in Oral Cancer

2021
In 2008, the gene ANO1 was discovered to encode a calcium activated chloride channel. This gene is located on the 11q13 locus, a locus that is commonly amplified in many cancers including cancer of the head and neck. ANO1 is situated in close proximity to genes associated with growth and apoptosis.
openaire   +1 more source

Regulation of ANO1/TMEM16A anion permeability

Pancreatology, 2013
Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung, Joo Hyun Nam, Hyun Woo Park, Uhtaek Oh, Joo-heon Yoon, Min Goo Lee   +5 more
openaire   +1 more source

Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms

2018
Primary sensory neurons detect potentially dangerous environmental situations via many "sensor" proteins located on the plasma membrane. Although receptor-type cation channels are thought to be the major sensors in sensory neurons, anion channels are also important players in the peripheral nervous system.
Y, Takayama, Makoto, Tominaga
openaire   +2 more sources

Functional analysis of the antisense long noncoding RNA ANO1-AS2 and the ANO1 gene in Iraqi men with idiopathic infertility

Asia Pacific Journal of Molecular Biology and Biotechnology
The leading causes of male infertility remain unclear. Men with average semen analysis results are diagnosed with idiopathic infertility. The ANO1-AS2 gene is a long noncoding RNA located close to the anoctamin1 (ANO1) gene. ANO1 regulates calcium-activated chloride channels, which regulate many cellular processes.
Shimaa Jumaa Abood, Maan Hasan Salih, Mohammad Mutlag Salih   +2 more
openaire   +1 more source