Results 111 to 120 of about 27,267,955 (206)
Cell-specific mechanisms of TMEM16A Ca2+-activated chloride channel in cancer
Molecular Cancer, 2017 TMEM16A (known as anoctamin 1) Ca2+-activated chloride channel is overexpressed in many tumors. TMEM16A overexpression can be caused by gene amplification in many tumors harboring 11q13 amplification.
Hui Wang +6 more
doaj +1 more source
Context-dependent compensation among phosphatidylserine-recognition receptors [PDF]
, 2017 Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance.
Han, Claudia Z +11 more
core +3 more sources
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function [PDF]
Kidney International, 2014 The role of calcium-activated chloride channels for renal function is unknown. By immunohistochemistry we demonstrate dominant expression of the recently identified calcium-activated chloride channels, Anoctamin 1 (Ano1, TMEM16A) in human and mouse proximal tubular epithelial (PTE) cells, with some expression in podocytes and other tubular segments ...
Diana, Faria +11 more
openaire +2 more sources
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
Postnatal odorant exposure induces peripheral olfactory plasticity at the cellular level [PDF]
, 2014 Mammalian olfactory sensory neurons (OSNs) form the primary elements of the olfactory system. Inserted in the olfactory mucosa lining of the nasal cavity, they are exposed to the environment and their lifespan is brief.
AOUDE, Imad +6 more
core +3 more sources
Clinical &Translational Immunology, Volume 15, Issue 4, 2026.In samples collected before the onset of multiple sclerosis (MS), we show that seropositivity against rubella virus (RV) envelope protein 1 (E1) was associated with increased risk of developing MS. Furthermore, at group level, cases had higher seroreactivity against RV E1 compared to matched controls before a significant increase in neurofilament light
Jens Ingvarsson +12 more
wiley +1 more source
N-1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism [PDF]
, 2018 Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To
Ahlqvist, Emma +25 more
core +2 more sources
EBV Genome Variations and Association With Diseases
Journal of Medical Virology, Volume 98, Issue 4, April 2026.ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin +5 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous physiological processes including cell proliferation, migration, and extracellular matrix secretion. T16Ainh-A01 and CaCCinh-A01 are selective inhibitors of CaCCs.
Xiang-qin Tian +5 more
doaj +1 more source
Chondroprotection by urocortin involves blockade of the mechanosensitive ion channel Piezo1 [PDF]
, 2017 Osteoarthritis (OA) is characterised by progressive destruction of articular cartilage and chondrocyte cell death. Here, we show the expression of the endogenous peptide urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human ...
A Rosenhouse-Dantsker +62 more
core +1 more source