Results 121 to 130 of about 27,267,955 (206)

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
wiley   +1 more source

Anoctamin‐1 channel localization in excitable domains of the heart (893.23)

The FASEB Journal, 2014
Calcium‐activated chloride (Cl Ca ) currents are widely distributed in cardiac tissues and have been implicated to play a role in cardiac physiology and pathophysiology. Anoctamin‐1 (Ano1) is a membrane protein that functions as a Cl Ca channel and has ...
Fiona Britton, Kate O'Driscoll, William Hatton   +2 more
openaire   +1 more source

TMEM16A Contributes to Calcium‐Activated Chloride Currents and Membrane Potential Changes in the Mouse Oocyte

Journal of Cellular Physiology, Volume 241, Issue 3, March 2026.
ABSTRACT Oscillations in intracellular Ca2+ [Ca2+]i are essential for mouse oocyte activation following fertilization. These [Ca2+]i oscillations also induce repetitive hyperpolarizations in the membrane potential (Em). The present study aimed to identify the channels underlying the Em hyperpolarizations.
Sarah Dalati, Vanessa J. Jones, Margot L. Day   +2 more
wiley   +1 more source

Treg cells retain stable lineage commitment during pregnancy in mice after late gestation inflammatory challenge

Immunology &Cell Biology, Volume 104, Issue 3, Page 276-311, March 2026.
In this study, we used Foxp3‐fatemapping mice to examine the cell lineage stability of Treg cells in pregnancy. Ex‐Foxp3 cells were identified in gestational tissues. However, Treg cells retained lineage stability with no increased ex‐Foxp3 generation, regardless of inflammatory challenges that induce preterm birth.
Kerrie L Foyle, Ella S Green, Jessie R Walker‐Rogers, Ha M Tran, David M Olson, Lachlan M Moldenhauer, Sarah A Robertson   +6 more
wiley   +1 more source

Rare variants in ANO1, encoding a calcium-activated chloride channel, predispose to moyamoya disease [PDF]

, 2023
Moyamoya disease, a cerebrovascular disease leading to strokes in children and young adults, is characterized by progressive occlusion of the distal internal carotid arteries and the formation of collateral vessels. Altered genes play a prominent role in
Aloui, Chaker, Alyemni, Saleh Omar, Bamshad, Michael J, Boerio, Maura L, Cecchi, Alana C, Fraser, Stuart M, Guey, Stéphanie, Guo, Dongchuan, Haider, Shozeb, He, Mu, Hickey, Scott E, Jan, Lily Yeh, Jin, Sheng Chih, Kahle, Kristopher T, Kraemer, Markus, Lee, Kwanghyuk, Milewicz, Dianna M, Nickerson, Deborah A, Pichurin, Pavel, Pinard, Amélie, Rosenfeld, Jill A, Smith, Edward R, Tournier-Lasserve, Elisabeth, Ye, Wenlei   +23 more
core   +1 more source

Characterization of TMEM16F-Specific Affibodies and Their Cellular Effects

Membranes
The TMEM16 (Anoctamin) family comprises a group of transmembrane proteins involved in diverse physiological processes, including ion transport and phospholipid scrambling.
Eunyoung Kim, Jinho Bang, Sunghyun Kim, Byoung-Cheol Lee   +3 more
doaj   +1 more source

Differential expression of anoctamin 1 in human epithelial ovarian cancer.

, 2021
Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of ...
openaire   +2 more sources

Anoctamin 1 is Apically Expressed on Thyroid Follicular Cells and Contributes to ATP- and Calcium-Activated Iodide Efflux

Cellular Physiology and Biochemistry, 2014
Background/Aims: Iodide efflux from thyroid cells into the follicular lumen is essential for the synthesis of thyroid hormones, however, the pathways mediating this transport have only been partially identified.
Carmela Iosco, Cristina Cosentino, Laura Sirna, Roberta Romano, Silvia Cursano, Alessandra Mongia, Giampaolo Pompeo, Julie di Bernardo, Claudio Ceccarelli, Giovanni Tallini, Kerry J. Rhoden   +10 more
doaj   +1 more source

LOCALISATION OF THE INTERSTITIAL CELLS OF CAJAL IN RAINBOW TROUT [PDF]

, 2022
The interstitial cells of Cajal (ICC) are primarily placed in the gastrointestinal tract, where they play a crucial role in the initiation and control of motility by operating as pacemaker cells. They also have a role in neurotransmission.
Nilsson, Ellen
core  

Control of Ion Transport by Tmem16a Expressed in Murine Intestine

Frontiers in Physiology, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann, Raquel Centeio, Podchanart Wanitchakool, Inês Cabrita, Roberta Benedetto, Tultul Saha, Kazi Mirajul Hoque, Kazi Mirajul Hoque, Rainer Schreiber   +8 more
doaj   +1 more source