Results 101 to 110 of about 27,267,955 (206)

Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines. [PDF]

PLoS ONE, 2015
The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration.
Yohan Seo, Jinhong Park, Minseo Kim, Ho K Lee, Jin-Hee Kim, Jin-Hyun Jeong, Wan Namkung   +6 more
doaj   +1 more source

TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]

, 2016
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario, McGeown, J. Graham, Nagy, Istvan, Nilius, Bernd, Urban, Laszlo, White, John P M   +5 more
core   +1 more source

Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Cystic fibrosis (CF) airway epithelium is constantly subjected to injury events due to chronic infection and inflammation. Moreover, abnormalities in CF airway epithelium repair have been described and contribute to the lung function decline seen in CF patients. In the last past years, it has been proposed that anoctamin 1 (ANO1), a Ca(2+)-activated Cl(
Ruffin, Manon, Voland, Mélanie, Marie, Solenne, Bonora, Monique, Blanchard, Elise, Blouquit-Laye, Sabine, Naline, Emmanuel, Puyo, Philippe, Le Rouzic, Philippe, Guillot, Loic, Corvol, Harriet, Clement, Annick, Tabary, Olivier   +12 more
openaire   +4 more sources

Molecular Mimicry Between Epstein‐Barr Virus and Human Herpesvirus‐6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background The Epstein‐Barr virus (EBV) and human herpesvirus 6 (HHV‐6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis. These viruses may induce autoimmune reactions by molecular mimicry, leading to damage to self‐epitopes in the central nervous
Abbas F. Almulla, Muslimbek G. Normatov, Thitiporn Supasitthumrong, Michael Maes   +3 more
wiley   +1 more source

TMEM16A in Cystic Fibrosis: Activating or Inhibiting?

Frontiers in Pharmacology, 2019
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction due to mucus hypersecretion, airway plugging, and bronchoconstriction.
Karl Kunzelmann, Jiraporn Ousingsawat, Inês Cabrita, Tereza Doušová, Andrea Bähr, Andrea Bähr, Melanie Janda, Rainer Schreiber, Roberta Benedetto   +8 more
doaj   +1 more source

Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor [PDF]

, 2013
The biolipid sphingosine-1-phosphate (S1P) is an essential modulator of innate immunity, cell migration, and wound healing. It is released locally upon acute tissue injury from endothelial cells and activated thrombocytes and, therefore, may give rise to
Andratsch, Manfred, Benetti, Camilla, Beroukas, Dimitra, Camprubi-Robles, Maria, Ferrer-Montiel, Antonio V, Haberberger, Rainer Viktor, Kress, Michaela, Langeslag, Michiel, Mair, Norbert, Proia, Richard L, Rukwied, Roman, Schmelz, Martin   +11 more
core   +1 more source

Neuroinflammation as a result of non‐neurotropic herpesvirus infection

Immunology &Cell Biology, Volume 104, Issue 5, Page 443-451, May‐June 2026.
Atypical memory B cells (ABCs) might stimulate autoreactive T cells to cause neuroinflammation and CNS myeloid cell activation during MS. Abstract The non‐neurotropic Epstein Barr virus (EBV) has been suggested to initiate the prodromal phase of multiple sclerosis (MS), often years before the first clinical symptoms. This review discusses mechanisms by
Christian Münz
wiley   +1 more source

Extrinsic primary afferent signalling in the gut [PDF]

, 2013
Visceral sensory neurons activate reflex pathways that control gut function and also give rise to important sensations, such as fullness, bloating, nausea, discomfort, urgency and pain.
A Akbar, A Iggo, A Paintal, A Willis, AD Craig, AG Meehan, AG Meehan, AJ Page, AJ Page, AJ Page, AM Binshtok, AM Brunsden, AM Brunsden, AS Paintal, AV Keita, B Feng, B Feng, B Feng, B Nilius, B Nilius, BC Tassicker, BF Leek, BS Ray, BZ Sirotin, C Eastwood, C Feinle, C Olsson, C Olsson, CL Kwan, CR Abbott, D Denny-Brown, D Grundy, DA Cockayne, DF Cottrell, DR Robinson, EA Fox, EA Mayer, F Cattaruzza, F Zhong, FB Wang, G Hewson, G Rindi, G Wynn, GA Hicks, GD Clarke, GJ Sanger, GP Smith, H Blumberg, H Cho, H Kawasaki, H Sann, HE Raybould, HR Berthoud, HR Berthoud, HR Berthoud, HU De Schepper, IL Gibbins, J Doerffler-Melly, J Gibbs, JA Slattery, JB Furness, JC Longhurst, JC Longhurst, JF Morrison, JM Gschossmann, JN Sengupta, JN Sengupta, JX Zhu, K Dembowsky, K Floyd, K Hillsley, KA Petersen, KA Sharkey, L Bartho, L Rinaman, L Van Oudenhove, LA Blackshaw, LA Blackshaw, LA Blackshaw, M Andratsch, M Dutsch, M Figini, M Kyloh, M Peiris, M Steinhoff, M Takaki, M Takaki, M Yamanouchi, Marcello Costa, MD Gershon, ME Kreis, MJ Beyak, MP Jones, MR Matthews, N Cenac, Nick J. Spencer, NJ Spencer, NJ Spencer, P Bessou, P Forsythe, P Haupt, P Holzer, P Holzer, P Lynn, PA Hughes, PA Lynn, PA Lynn, PA Lynn, PL Andrews, PLR Andrews, Q Sang, R Melzack, R Miyamoto, R Uddman, RE Steinert, RJ Traub, RL Batterham, S Carmagnola, S Kentish, S Koda, S Lal, S Vanner, S Yu, SA Malin, SD Smid, Simon J. H. Brookes, SJH Brookes, SK Suckow, SM Brierley, SM Brierley, SM Brierley, SM Brierley, SM Collins, SM Ward, SP Cook, SSC Rao, T Hayakawa, T Lembo, TJ Hibberd, TJ Hibberd, TJ Ness, TL Powley, TL Powley, Vladimir P. Zagorodnyuk, VP Zagorodnyuk, VP Zagorodnyuk, VP Zagorodnyuk, VP Zagorodnyuk, W Janig, W Jiang, WC De Groat, WEB Sipe, WL Neuhuber, WL Neuhuber, WM Bayliss, X Song, X Zhang, Y Li, Y Li, Y Yiangou, YC Woo   +160 more
core   +2 more sources

Identification and characterization of a novel Anoctamin 1 inhibitor and its anticancer effects

The FASEB Journal, 2020
Anoctamin 1 (ANO1 also known as TMEM16A) is a calcium‐activated chloride channel that is amplified in various carcinomas including prostate cancer, esophageal cancer, breast cancer, and pancreatic cancer, and its overexpression promotes cell ...
S. Jo, Yohan Seo, W. Namkung
semanticscholar   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females?

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn, Nuria Alvarez‐Sanchez, Lawrence Steinman   +2 more
wiley   +1 more source