Role of Anoctamin-1 and Bestrophin-1 in Spinal Nerve Ligation-Induced Neuropathic Pain in Rats [PDF]
Molecular Pain, 2015 Background Calcium-activated chloride channels (CaCCs) activation induces membrane depolarization by increasing chloride efflux in primary sensory neurons that can facilitate action potential generation. Previous studies suggest that CaCCs family members
Jorge Baruch Pineda-Farias +7 more
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Light conditions affect rhythmic expression of aquaporin 5 and anoctamin 1 in rat submandibular glands [PDF]
Heliyon, 2019 Circadian rhythms regulate various physiological functions and are, therefore, essential for health. Light helps regulate the master and peripheral clocks. The secretion rates of saliva and electrolytes follow a circadian rhythm as well.
Ryouichi Satou +3 more
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Transmembrane protein 16A/anoctamin 1 inhibitor T16A-A01 reversed monocrotaline-induced rat pulmonary arterial hypertension [PDF]
Pulmonary Circulation, 2020 Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it was considered as potential target for pulmonary arterial hypertension treatment.
Jianye Xie +9 more
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Anoctamin 1 Contributes to Inflammatory and Nerve-Injury Induced Hypersensitivity [PDF]
Molecular Pain, 2014 Background: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli.
Byeongjun Lee +5 more
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Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin [PDF]
Experimental and Molecular Medicine, 2019 Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee +12 more
doaj +2 more sources
Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
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Temporal Expression Patterns of Clock Genes and Aquaporin 5/Anoctamin 1 in Rat Submandibular Gland Cells [PDF]
Frontiers in Physiology, 2017 Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues.
Ryouichi Satou +6 more
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Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
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Anoctamin 1 (TMEM16A) is essential for testosterone-induced prostate hyperplasia [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Ho-Young Lee +2 more
exaly +2 more sources
Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
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