Results 31 to 40 of about 2,904 (115)

Generation of two TMEM16A knockout iPSC clones each from a healthy human iPSC line, from a Cystic Fibrosis patient specific line with p.Phe508del mutation and from the gene corrected iPSC line

Stem Cell Research, 2022
The Transmembrane member 16A (TMEM16A), also known as anoctamin-1 (ANO1), is a calcium-activated chloride channel present in the airway epithelium. It is known to be involved in the apical chloride secretion indicating that TMEM16A could be addressed for
Mark-Christian Jaboreck, Jonathan Lukas Lühmann, Mia Mielenz, Frauke Stanke, Gudrun Göhring, Ulrich Martin, Ruth Olmer, Sylvia Merkert   +7 more
doaj   +1 more source

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. [PDF]

PLoS ONE, 2013
Calcium (Ca(2+))-activated chloride (Cl(-)) channels (CaCCs) play a role in the modulation of action potentials and synaptic responses in the somatodendritic regions of central neurons. In the vertebrate retina, large Ca(2+)-activated Cl(-) currents (ICl(
Ji Hyun Jeon, Sun Sook Paik, Myung-Hoon Chun, Uhtaek Oh, In-Beom Kim   +4 more
doaj   +1 more source

Testosterone secretion is affected by receptor tyrosine kinase c-Kit and anoctamin 1 activation in mouse Leydig cells

Journal of Animal Reproduction and Biotechnology, 2022
Receptor tyrosine kinase c-Kit, a marker found on interstitial cells of Cajal (ICCs), is expressed in Leydig cells, which are testicular interstitial cells. The expression of other ICC markers has not yet been reported. In this study, we investigated the
Eun-A Ko, Min Seok Woo, Dawon Kang
doaj   +1 more source

Effects of protein diet on expression of Anoctamin1 of Cajal cell in the nervous plexus of the stomach in male mice

Journal of the Pakistan Medical Association
Objective: To determine the association between a protein-rich diet and the expression of anoctamin 1 in Interstitial cells of Cajal within the muscle layer of the stomach wall in male mice.
Khulood Ayad Majeed, Haider Abdal-Rasool Jaafar, Hiba Majed Rasol   +2 more
doaj   +1 more source

Discovery of 4-arylthiophene-3-carboxylic acid as inhibitor of ANO1 and its effect as analgesic agent

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) is a kind of calcium-activated chloride channel involved in nerve depolarization. ANO1 inhibitors display significant analgesic activity by the local peripheral and intrathecal administration. In this study, several thiophenecarboxylic
Yuxi Wang, Jian Gao, Song Zhao, Yan Song, Han Huang, Guiwang Zhu, Peili Jiao, Xiangqing Xu, Guisen Zhang, Kewei Wang, Liangren Zhang, Zhenming Liu   +11 more
doaj   +1 more source

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Nature Communications, 2019
The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells.
Anamika Dayal, Shu Fun J. Ng, Manfred Grabner   +2 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer

International Journal of General Medicine, 2022
Jun Chen,1,* Hongli Wang,2,* Fang Peng,3,* Haiyan Qiao,1 Linfeng Liu,1 Liang Wang,1 Bingbing Shang4 1Laboratory Animal Center, Dalian Medical University, Dalian, 116044, Liaoning Province, People’s Republic of China; 2Cardiology Department ...
Chen J, Wang H, Peng F, Qiao H, Liu L, Wang L, Shang B   +6 more
doaj  

ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers

Frontiers in Pharmacology, 2023
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growth and ...
SeonJu Park, Raju Das, Nguyen Xuan Nhiem, Nguyen Xuan Nhiem, Sung Baek Jeong, Minuk Kim, Dongguk Kim, Hye In Oh, Su-Hyeon Cho, Oh-Bin Kwon, Jae-Hyeog Choi, Chul Soon Park, Song-Rae Kim, Uk Yeol Moon, Boksik Cha, Dong Kyu Choi, Sungwoo Lee, Wan Namkung, Joohan Woo, Joohan Woo, Yohan Seo   +20 more
doaj   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source