Results 21 to 30 of about 2,904 (115)

Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
Daisuke Uta, Hidemasa Furue, Makoto Tominaga   +2 more
exaly   +2 more sources

TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis

Cells, 2021
Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator ...
Christie Mitri, Himanshu Sharma, Harriet Corvol, Olivier Tabary   +3 more
doaj   +1 more source

Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling

Frontiers in Physiology, 2020
Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj   +1 more source

Anoctamin-1 is induced by TGF-β and contributes to lung myofibroblast differentiation

American Journal of Physiology - Lung Cellular and Molecular Physiology
Nickolai Dulin, Mutlu Gm, Alexander A Mongin   +2 more
exaly   +2 more sources

Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f

Gastro Hep Advances, 2022
Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber, Ines Cabrita, Karl Kunzelmann   +2 more
doaj   +1 more source

Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility [PDF]

American Journal of Obstetrics and Gynecology, 2014
Joy Vink, Kyra Bernstein, Ronald Wapner   +2 more
exaly   +2 more sources

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

FASEB BioAdvances, 2020
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion across several transporting epithelia, including in the airways. Additional roles for TMEM16A have been proposed, which include regulating mucus production and secretion and
Henry Danahay, Roy Fox, Sarah Lilley, Holly Charlton, Kathryn Adley, Lee Christie, Ejaz Ansari, Camille Ehre, Alexis Flen, Michael J. Tuvim, Burton F. Dickey, Colin Williams, Sarah Beaudoin, Stephen P Collingwood, Martin Gosling   +14 more
doaj   +1 more source

MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Nature Communications, 2017
Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse ...
Florence Sonneville, Manon Ruffin, Christelle Coraux, Nathalie Rousselet, Philippe Le Rouzic, Sabine Blouquit-Laye, Harriet Corvol, Olivier Tabary   +7 more
doaj   +1 more source

Anoctamin 1 Inhibition Suppresses Cystogenesis by Enhancing Ciliogenesis and the Ciliary Dosage of Polycystins

Frontiers in Bioscience-Landmark, 2022
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu, Meihan Chen, Qingwen Xu, Cheng Xue, Lili Fu, Kun Ling, Jinghua Hu, Changlin Mei   +7 more
doaj   +1 more source

Chloride – The Underrated Ion in Nociceptors

Frontiers in Neuroscience, 2020
In contrast to pain processing neurons in the spinal cord, where the importance of chloride conductances is already well established, chloride homeostasis in primary afferent neurons has received less attention.
Bettina U. Wilke, Kai K. Kummer, Michael G. Leitner, Michaela Kress   +3 more
doaj   +1 more source