Results 21 to 30 of about 48,914 (162)

Chidamide increases the sensitivity of refractory or relapsed acute myeloid leukemia cells to anthracyclines via regulation of the HDAC3 -AKT-P21-CDK2 signaling pathway

Journal of Experimental & Clinical Cancer Research, 2020
Background Induction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a relapse or exhibit refractory disease (R/R).
Hao Wang, Yu-chen Liu, Cheng-ying Zhu, Fei Yan, Meng-zhen Wang, Xiao-su Chen, Xiao-kai Wang, Bao-xu Pang, Yong-hui Li, Dai-hong Liu, Chun-ji Gao, Shu-jun Liu, Li-ping Dou   +12 more
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Evaluating the expression of heat shock protein 27 and topoisomerase II α in a retrospective cohort of patients diagnosed with locally advanced breast cancer and treated with neoadjuvant anthracycline-based chemotherapies

Frontiers in Oncology, 2023
BackgroundNeoadjuvant anthracycline-based chemotherapy (NAC) is a major regimen for the treatment of local advanced breast cancer (LABC), while resistance to NAC remains a paramount clinical obstacle.
Yixuan Zhuang, Yixuan Zhuang, Fan Zhang, Yue Xu, Lifang He, Wenhe Huang, Chaoqun Hong, Yukun Cui   +7 more
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Recent Advances in the Mechanisms of Cell Death and Dysfunction in Doxorubicin Cardiotoxicity

Reviews in Cardiovascular Medicine, 2023
Despite recent advances in cancer therapy, anthracycline-based combination therapy remains the standardized first-line strategy and has been found to have effective antitumor actions.
Tian-Hu Wang, Yan Ma, Shan Gao, Wei-Wei Zhang, Dong Han, Feng Cao   +5 more
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Cardiac Surveillance for Early Detection of Late Subclinical Cardiac Dysfunction in Childhood Cancer Survivors After Anthracycline Therapy

Frontiers in Oncology, 2021
BackgroundIn childhood cancer survivors (CCSs) anthracycline-related cardiotoxicity is an important cause of morbidity and late mortality, but the optimal modality of cardiac surveillance still remains to be defined.
Rosaria Sofia, Rosaria Sofia, Veronica Melita, Antonio De Vita, Antonio De Vita, Antonio Ruggiero, Antonio Ruggiero, Alberto Romano, Alberto Romano, Giorgio Attinà, Giorgio Attinà, Lisa Birritella, Lisa Birritella, Priscilla Lamendola, Priscilla Lamendola, Antonella Lombardo, Antonella Lombardo, Gaetano Antonio Lanza, Gaetano Antonio Lanza, Angelica Bibiana Delogu, Angelica Bibiana Delogu   +20 more
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Efficacy and safety of cardiac resynchronization therapy in chemotherapy‐induced cardiomyopathy: A systematic review

Annals of Noninvasive Electrocardiology, 2023
Objective The aim of the study was to assess the efficacy of cardiac resynchronization therapy (CRT) in patients with chemotherapy‐induced cardiomyopathy (CIC).
Muhammad Shehram, Hiba Khalid, Hafiz Muhammad Shafique, Bakht Umer, Awais Zafar, Asif Ullah, Syed Muhammad Jawad Zaidi, Jawad Basit, Amin Mehmoodi, Jahanzeb Malik   +9 more
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Severe Cardiac Toxicity Induced by Cancer Therapies Requiring Intensive Care Unit Admission

Frontiers in Cardiovascular Medicine, 2021
A steadying increase of cancer survivors has been observed as a consequence of more effective therapies. However, chemotherapy regimens are often associated with significant toxicity, and cardiac damage emerges as a prominent clinical issue.
Andrea Montisci, Vittorio Palmieri, Jennifer E. Liu, Maria T. Vietri, Silvia Cirri, Francesco Donatelli, Claudio Napoli, Claudio Napoli   +7 more
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3′,4′-Dihydroxyflavonol Modulates the Cell Cycle in Cancer Cells: Implication as a Potential Combination Drug in Osteosarcoma

Pharmaceuticals, 2021
New agents are demanded to increase the therapeutic options for osteosarcoma (OS). Although OS is the most common bone cancer in children and adolescents, it is considered a rare disorder.
José Miguel P. Ferreira de Oliveira, Joana Filipa D. Almeida, Maria Martins, Carina Proença, Helena Oliveira, Eduarda Fernandes, Conceição Santos   +6 more
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Effects of the Chinese herbal medicine Hong Huang decoction, on myocardial injury in breast cancer patients who underwent anthracycline-based chemotherapy

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo assess the effects of Hong Huang Decoction (HHD), a Chinese herbal medicine, on myocardial injury in breast cancer patients who underwent anthracycline (ANT)-based chemotherapy.MethodsA total of 51 patients with breast cancer who underwent an
Sihan Cao, Sihan Cao, Jingxian Xue, Lu Chen, Lu Chen, Yun Hao, Yun Hao, Meijuan Lu, Ming Feng, Ming Feng, Huanhuan Wang, Huanhuan Wang, Jun Zhou, Chang Yao   +13 more
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Use of integrated imaging and serum biomarker profiles to identify subclinical dysfunction in pediatric cancer patients treated with anthracyclines

Cardio-Oncology, 2018
Background Anthracycline induced cardiomyopathy is a major cause of mortality and morbidity among pediatric cancer survivors. It has been postulated that oxidative stress induction and inflammation may play a role in the pathogenesis of this process ...
Olga H. Toro-Salazar, Ji Hyun Lee, Kia N. Zellars, Paige E. Perreault, Kathryn C. Mason, Zhu Wang, Kan N. Hor, Eileen Gillan, Caroline J. Zeiss, Daniel M. Gatti, Brooke T. Davey, Shelby Kutty, Bruce T. Liang, Francis G. Spinale   +13 more
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Small cell lung cancer responds to immunogenic chemotherapy followed by PD-1 blockade

OncoImmunology, 2021
Sequential combination of immunogenic cell death (ICD)-induced interventions with subsequent immunotherapy has shown efficacy in preclinical models and clinical evaluation. Recently, a clinical trial enrolling small cell lung cancer patients treated with
Guido Kroemer, Oliver Kepp
doaj   +1 more source