Results 31 to 40 of about 48,914 (162)

Assessment of Myocardial Work in Cancer Therapy-Related Cardiac Dysfunction and Analysis of CTRCD Prediction by Echocardiography

Frontiers in Pharmacology, 2021
No study has examined myocardial work in subjects with cancer therapy-related cardiac dysfunction (CTRCD). Myocardial work, as a new ultrasonic indicator, reflects the metabolism and oxygen consumption of the left ventricle.
Jingyuan Guan, Wuyun Bao, Yao Xu, Wei Yang, Mengmeng Li, Mingjun Xu, Yu Zhang, Mei Zhang   +7 more
doaj   +1 more source

Drug-Induced Interstitial Lung Disease after Anthracycline-Combined Chemotherapy for Breast Cancer: A Case Report and Literature Review

Case Reports in Oncology, 2021
Drug-induced interstitial lung disease (DILD) has been occasionally reported with various causative drugs. In the context of breast cancer, anthracycline infrequently causes pulmonary adverse events.
Hideko Hoshina, Hiroyuki Takei
doaj   +1 more source

Cardiac safety of trabectedin monotherapy or in combination with pegylated liposomal doxorubicin in patients with sarcomas and ovarian cancer

Cancer Medicine, 2021
Background As with other alkylating agents, cardiac dysfunction can occur with trabectedin therapy for advanced soft tissue sarcomas (STS) or recurrent ovarian cancer (ROC) where treatment options for advanced disease are still limited.
Robin L. Jones, Thomas J. Herzog, Shreyaskumar R. Patel, Margaret von Mehren, Scott M. Schuetze, Brian A. Van Tine, Robert L. Coleman, Roland Knoblauch, Spyros Triantos, Peter Hu, Waleed Shalaby, Tracy McGowan, Bradley J. Monk, George D. Demetri   +13 more
doaj   +1 more source

Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging

Frontiers in Cardiovascular Medicine, 2022
Anthracyclines are a widely used class of chemotherapy in pediatric and adult cancers, however, their use is hampered by the development of cardiotoxic side-effects and ensuing complications, primarily heart failure. Clinically used imaging modalities to
Jeremy Jong, James R. Pinney, James R. Pinney, James R. Pinney, René R. Sevag Packard, René R. Sevag Packard, René R. Sevag Packard, René R. Sevag Packard   +7 more
doaj   +1 more source

microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice

Frontiers in Cardiovascular Medicine, 2021
Doxorubicin (DOX, an anthracycline) is a widely used chemotherapy agent against various forms of cancer; however, it is also known to induce dose-dependent cardiotoxicity leading to adverse complications. Investigating the underlying molecular mechanisms
John Henderson, Praveen K. Dubey, Mallikarjun Patil, Sarojini Singh, Shubham Dubey, Rajasekaran Namakkal Soorappan, Ramaswamy Kannappan, Palaniappan Sethu, Gangjian Qin, Jianyi Zhang, Prasanna Krishnamurthy   +10 more
doaj   +1 more source

Anthracycline Cardiotoxicity in Children [PDF]

New England Journal of Medicine, 2004
More than 70 percent of children who are treated for childhood cancer can be cured. For long-term survivors, possible late effects of treatment and their consequences for the quality of life are a major concern. Cardiotoxic effects of anthracyclines are among the most frequent and serious adverse effects of the treatment of childhood cancer ...
Kremer, L.C.M., Caron, H.N.
openaire   +5 more sources

Local arterial stiffness measured by ultrafast ultrasound imaging in childhood cancer survivors treated with anthracyclines

Frontiers in Cardiovascular Medicine, 2023
BackgroundThere is conflicting literature regarding the long-term effect of anthracycline treatment on arterial stiffness. This study assessed local arterial stiffness using ultrafast ultrasound imaging (UUI) in anthracycline treated childhood cancer ...
Rahna Rasouli, Jerome Baranger, Cameron Slorach, Wei Hui, Maelys Venet, Minh B. Nguyen, Matthew Henry, Josh Gopaul, Paul C. Nathan, Luc Mertens, Olivier Villemain   +10 more
doaj   +1 more source

Case report: Complete atrio-ventricular block successfully reversed in newly diagnosed primary cardiac B-cell lymphoma

Frontiers in Medicine, 2023
Primary cardiac tumors are extremely uncommon and primary cardiac lymphoma (PCL) is an even rarer subset. A definite diagnosis can be delayed, which increases the likelihood of a poor prognosis. We report a case involving a 64-year-old male who presented
Jiahui Mao, Yitong Xu, Yitong Xu, Mingfang Zhu, Mingfang Zhu, Luqun Wang, Yu Hou, Yu Hou   +7 more
doaj   +1 more source

The Omission of Anthracycline Chemotherapy in Women with Early HER2-Negative Breast Cancer—A Systematic Review and Meta-Analysis

Current Oncology
Background: Anthracycline-taxane is the standard chemotherapy strategy for treating high-risk early breast cancer despite the potentially life-threatening adverse events caused by anthracyclines.
Danilo Giffoni de Mello Morais Mata, Mary-Beth Rush, Megan Smith-Uffen, Jawaid Younus, Ana Elisa Lohmann, Maureen Trudeau, Rebecca L. Morgan   +6 more
doaj   +1 more source

Pharmacokinetics of Anthracyclines [PDF]

Acta Oncologica, 1989
The plasma pharmacokinetics of the two commonly used anthracyclines doxorubicin and 4'epi-doxorubicin have been studied by reversed phase liquid chromatography with photometric detection. After intravenous administration the plasma pharmacokinetics of doxorubicin and 4'epi-doxorubicin are characterized by the three compartment open model.
openaire   +2 more sources