Results 61 to 70 of about 34,211 (250)

Drug-Induced Heart Failure (Part 1: The Urgency of the Problem, the Prevalence, the Effect of Certain Groups of Drugs on the Risk of Development/Progression Heart Failure)

Безопасность и риск фармакотерапии, 2020
Despite all the achievements of modern medicine, heart failure remains one of the most prevalent, severe and prognostically unfavorable conditions that requires close attention of the medical community. The diversity of the clinical picture and the large
O. D. Ostroumova, I. V. Goloborodova
doaj   +1 more source

Asymmetric Synthesis of Anticancer Anthracyclines PhD thesis

, 2014
Some of the experimental part from my PhD thesis entitled 'Asymmetric Synthesis of Anticancer Anthracyclines', University of Manchester, U.K., 1994. Author Jonathan P. Miller.
Miller, Jonathan
core   +1 more source

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

Advanced Science, EarlyView.
The C3‐symmetric conjugate TASe, which integrates benzoselenadiazole, alanine, and acylhydrazone modules, self‐assembles into a chalcogen‐/hydrogen‐bonded porous framework in the solid state and uniform chiral nanospheres in aqueous media. These assemblies protect cardiomyocytes from doxorubicin‐induced oxidative injury by scavenging intracellular ...
Jinkui Teng, Renjing Yang, Yu Du, Jingzhong Duan, Yiming Xu, Zhihua He, Guanghui Wang, Wenjing Tian, Aijie Liu, Haifeng Chen, Yun‐Bao Jiang, Xiaosheng Yan   +11 more
wiley   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives

Biomolecules
Anthracyclines have been clinically well established in cancer chemotherapy for decades. The main limitations of this drug class are the development of resistance and severe side effects.
Rümeysa Yücer, Rossana Piccinno, Ednah Ooko, Mona Dawood, Gerhard Bringmann, Thomas Efferth   +5 more
doaj   +1 more source

State of Vegetative Homeostasis in Children with Anthracycline-Induced Cardiomyopathy

Zdorovʹe Rebenka, 2014
The paper presents the results of investigation of the autonomic nervous system in children with acute lymphoblastic leukemia, in whom as a result of protocol chemotherapy with anthracycline antibiotics application, toxic anthracycline-induced ...
T.V. Shatynska, O.B. Synoverska, S.B. Shkandriy   +2 more
doaj   +1 more source

Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer

, 2009
Background One of the most important adverse effects of anthracyclines is cardiotoxicity. A well-informed decision on the use of anthracyclines in the treatment of different types of childhood cancer should be based on the available evidence on both ...
Martine F Raphaël, Huib N Caron, Leontien CM Kremer, Raphaël, Martine F., Caron, Huib N., Kremer, Leontien C. M., Elvira C van Dalen, van Dalen, Elvira C.   +7 more
core   +1 more source

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

Folate homeostasis of cancer cells affects sensitivity to not only antifolates but also other non-folate drugs: effect of MRP expression

Pteridines, 2013
Sensitivity to antifolates can be decreased by endogenous or exogenous folates. Leucovorin protects cancer patients against toxicity of the dihydrofolate reductase inhibitor methotrexate (MTX), while folic acid is used to protect rheumatoid arthritis ...
Peters Godefridus J., Kathmann Ietje, Lemos Clara, Hooijberg Jan Hendrik, Losekoot Nienke, Jansen Gerrit   +5 more
doaj   +1 more source

Anthracyclines and mitochondria

, 2011
Anthracyclines remain the cornerstone in the treatment of many malignancies including lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent chemotherapeutics is severely limited by the development of a progressive dose ...
Giardina, Bruno, Martorana, Giuseppe Ettore, Mordente, Alvaro, Andrea Silvestrini, Silvestrini, Andrea, Meucci, Elisabetta, Bruno Giardina, Alvaro Mordente, Giuseppe Ettore Martorana, Elisabetta Meucci   +9 more
core   +1 more source