Results 61 to 70 of about 47,221 (287)

Deciphering the Role of Cancer Stem Cells in Breast Cancer Brain Colonization Using a Novel Patient‐Derived Model

Advanced Healthcare Materials, EarlyView.
This study shows that stem‐like cells isolated from breast cancer brain metastases drive the spread and growth of tumors in the brain. Among them, a highly adhesive subgroup initiates metastasis and resists many drugs. By closely reflecting patient tumors, these models help identify new targets and improve the development of effective treatments ...
Stefania Faletti, Cristina Richichi, Daniela Osti, Elena Ceccacci, Giovanni Bertalot, Camilla Cerutti, Giuseppina Giardina, Adriana Marinaro, Brunella Costanza, Valentina Gambino, Elena Zaccheroni, Daniela Tosoni, Maria G. Filippone, Marcello Del Corvo, Yinxiu Zhan, Teresa Gravina, Davide Corà, Monica Patanè, Bianca Pollo, Maria Giovanna Jodice, Salvatore Pece, Babette B. Weksler, Ignacio A. Romero, Pierre‐Olivier Couraud, Elisabetta Munzone, Massimiliano Del Bene, Francesco DiMeco, Giuliana Pelicci   +27 more
wiley   +1 more source

Longitudinal strain analysis for assessment of early cardiotoxicity during anthracycline treatment in childhood sarcoma: A single center experience

Cancer Reports, 2023
Background The growing population of long‐term childhood cancer survivors encounter a substantial burden of cardiovascular complications. The highest risk of cardiovascular complications is associated with exposure to anthracyclines and chest radiation ...
Maria Sjöborg Alpman, Annica Jarting, Kerstin Magnusson, Aristomenis Manouras, Jan‐Inge Henter, Agneta Månsson Broberg, Nikolas Herold   +6 more
doaj   +1 more source

Cardioprotective Strategies for Doxorubicin-induced Cardiotoxicity: Present and Future

Рациональная фармакотерапия в кардиологии, 2022
The improvement of drugs and protocols of chemotherapeutic treatment has led to improved outcomes and survival in patients with cancer. But along with this, at first glance a positive point, there was another interdisciplinary problem, which is the need ...
A. M. Chaulin, D. V. Duplyakov
doaj   +1 more source

Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models [PDF]

, 2017
Purpose: Glioblastoma multiforme (GBM) is the most aggressive brain tumor. The activity of vosaroxin, a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, was investigated in GBM preclinical models as a ...
Colapietro, Alessandro, Di Cesare, Ernesto, Festuccia, Claudio, Fox, Judith A., Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mattei, Claudia, Rossi, Giulia, Ventura, Luca, Vetuschi, Antonella, Vitale, Flora   +11 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Novel schedule for treatment of inflammatory breast cancer [PDF]

, 2016
Inflammatory breast cancer (IBC) is the most aggressive form of this tumor, with the clinical and biological characteristics of a rapidly proliferating disease.
Cefalì, K, Corvino, R, D'Aniello, D, De Iuliis, F, Lanza, R, Scarpa, Susanna   +5 more
core  

Anthracycline-Induced Cardiotoxicity: Cardiac Monitoring by Continuous Wave-Doppler Ultrasound Cardiac Output Monitoring and Correlation to Echocardiography [PDF]

, 2012
Background: Anthracyclines are agents with a well-known cardiotoxicity. The study sought to evaluate the hemodynamic response to an anthracycline using real-time continuous-wave (CW)-Doppler ultrasound cardiac output monitoring (USCOM) and ...
Andreas Hausmann, Cardinale D, Cardinale D, Cardinale D, Cardinale D, Cheitlin MD, Cheitlin MD, Cooper LT, Cooper LT, Dey I, Dorothee Baur, Elliott P, Goorin AM, Gustafsson F, Hans Joachim Stemmler, Iwanaga Y, Jain D, Johanna Tischer, Kinnunen P, Knobloch K, Knobloch K, Knobloch K, Koh E, Lipshultz SE, Meinardi MT, Mueller C, Mueller C, Mueller T, Patricia Suhl, Petra Stieber, Rademaker MT, Ryberg M, Sandra Geiger, Sophia Horster, Steinherz LJ, Stemmler HJ, Tan HL, Urek R, van Lelyveld-Haas LE, Veronika Lange   +39 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives

Biomolecules
Anthracyclines have been clinically well established in cancer chemotherapy for decades. The main limitations of this drug class are the development of resistance and severe side effects.
Rümeysa Yücer, Rossana Piccinno, Ednah Ooko, Mona Dawood, Gerhard Bringmann, Thomas Efferth   +5 more
doaj   +1 more source

Zurich Consensus: Statement of German Experts on St. Gallen Conference 2011 on Primary Breast Cancer (Zurich 2011) [PDF]

, 2011
Every 2 years, the International Consensus Conference on the Treatment of Primary Breast Cancer takes place in St. Gallen. Given that the concept of the St.
Beckmann, Matthias W., Blohmer, Jens-Uwe, Costa, Serban-Dan, Diedrich, Klaus, Diel, Ingo, Eiermann, Wolfgang, Friese, Klaus, Gerber, Bernd, Harbeck, Nadia, Hilfrich, Jörn, Jackisch, Christian, Janni, Wolfgang, Jonat, Walter, Jänicke, Fritz, Kaufmann, Manfred, Kiechle, Marion, Kreienberg, Rolf, Köhler, Uwe, Maass, Nicolai, Marschner, Norbert, Minckwitz, Gunter von, Möbus, Volker, Nitz, Ulrike, Scharl, Anton, Schneeweiss, Andreas, Thomssen, Christoph, Untch, Michael, Wallwiener, Diethelm   +27 more
core   +1 more source