Results 51 to 60 of about 60,411 (263)

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Relationship between antibiotic exposure and subsequent mental health disorders in a primary care health system

Brain, Behavior, & Immunity - Health, 2022
Objective: To evaluate the relationship between antibiotic exposure and subsequent psychiatric disorders in a Pediatric primary care setting. Study design: We conducted a retrospective cohort study using electronic clinical record data for patients ages ...
Laura M. Prichett, Robert H. Yolken, Linxuan Wu, Emily G. Severance, Tina Kumra   +4 more
doaj  

A Phase 3 Multicenter, Double‐Blind Study Comparing Efficacy, Safety, Immunogenicity, and Pharmacokinetics of Alkem's Biosimilar Teriparatide Versus Reference Teriparatide in Postmenopausal Osteoporosis

AGING MEDICINE, EarlyView.
This phase III study demonstrated that Alkem's biosimilar teriparatide is noninferior to reference teriparatide in improving bone mineral density at the lumbar spine and femoral neck in postmenopausal osteoporosis patients, with comparable safety, pharmacodynamics, and immunogenicity profiles over 48 weeks of treatment.
Nitin Kapoor, Thomas Paul, Rajeshwar Nath Srivastava, Saurabh Singh, Sunil Maheshwari, Vishal Patil, Awadhesh Kumar Yadav, Girish Bhatia, Sushil H. Mankar, Joe Joseph Cherian, Surabhi Maheshwari, Sudeepti Srivastava, Dattatray Pawar, Roshan Pawar, Amol Aiwale, Amitrajit Pal, Yogesh Rane, Vinayaka Shahavi, Akhilesh Sharma   +18 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

An update on the pharmacological treatment of anxiety and related disorders

South African Family Practice, 2016
The anxiety disorders, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are common and debilitating, often coexist with medical and psychiatric conditions, and usually require long-term treatment.
K. Outhoff
doaj   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

How is therapeutic residential care constructed within key policy documents ?

Australian Journal of Social Issues, EarlyView.
Abstract Therapeutic residential care (TRC) is a mode of delivering out‐of‐home care (OOHC) that can help meet the needs of some of Australia's most vulnerable young people and their families. TRC programmes aim to support young people to develop positive relationship experiences in a safe and stable environment.
Lynne McPherson, Antonia Canosa, Kathomi Gatwiri, Donnah Anderson, Kylie Day, Robbie Gilligan, Anne Graham, Janise Mitchell, Tim Moore, Meaghan Vosz   +9 more
wiley   +1 more source

Study on the efficacy of compound porcine cerebroside and ganglioside injection in patients with ischemic stroke: A randomized, single‐center, open‐label, prospective study

Ibrain, EarlyView., 2023
Compound porcine perebroside and ganglioside injection (CPCGI) was used to treat ischemic stroke. However, there was no clinical evidence of low‐dose CPCGI. We conducted a clinical study to analyze whether the clinical results of low‐dose and standard‐dose CPCGI in patients with ischemic stroke were different.
Ya Chen, Xia Zhang, Hai‐Qing Zhang, Zhong Luo, Xue‐Jiao Zhou, Tao Liang, Fei Yang, Jun Zhang, Zu‐Cai Xu   +8 more
wiley   +1 more source

AB1040 CHARACTERIZATION OF ANXIETY AND DEPRESSION AND THEIR IMPACT ON DISEASE ACTIVITY, FATIGUE AND QUALITY OF LIFE IN SPONDYLARTHRITIS PATIENTS TREATED WITH ANTI-TUMOR NECROSIS FACTOR ALPHA AGENTS [PDF]

, 2023
D. Santos Oliveira, A. Martins, Rafaela Nicolau, Carlos Vaz, T. Martins-Rocha, A. Bernardo, M. Bernardes, L. Costa   +7 more
openalex   +1 more source

Caring Futures: Australian Attitudes About the Desirability of Care Work

Australian Journal of Social Issues, EarlyView.
ABSTRACT Amid increasing public and policy attention on the care and support sector, which millions of Australians rely upon for essential services, care workers continue to advocate for better pay and fairer conditions. This article draws on the concepts of recognition, value and social distribution from feminist ethics of care scholarship to explore ...
Laura Davy, Ariadne Vromen, Serrin Rutledge‐Prior, Molly Saunders   +3 more
wiley   +1 more source