Results 1 to 10 of about 356,007 (341)
IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS
International Journal of Pharmaceutical Sciences and Drug Research, 2018 Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma.
Shashank Shekhar Mishra +4 more
semanticscholar +4 more sources
Research on and developmental strategy of anti-asthmatic agents
Folia Pharmacologica Japonica, 2008 気管支喘息の基本となる病態が気道の慢性炎症であることから，吸入ステロイド薬を中心とした抗炎症療法の導入は喘息症状のコントロールを可能にし，喘息患者のquality of lifeを飛躍的に向上させた．その一方で，分子レベルでの病態への理解が深まり，特に気道炎症の発症・進展に関わる過程と関連する各種因子の解明が進むことで，より安全で効果的な治療薬の創製に向けた研究開発が試みられている．本稿では，気道炎症の制御を作用メカニズムとした新規喘息治療薬に焦点をあて，その概略を紹介する．
Ryuichi Totsuka, M. Kikuchi
semanticscholar +6 more sources
Synthesis and Biological Activity of Chalcone Derivatives as Anti - Asthmatics Agents [PDF]
Chemical Science Transactions, 2016 The objective of this study was to explore novel compounds with benzylideneactophenone moiety, which have potential for anti-asthmatic activity and can be potential candidates for PDE4 inhibitory activity.
Manuvesh Sangwan, Devender Pathak
semanticscholar +3 more sources
International Journal of Research and Development in Pharmacy & Life Sciences, 2018 The aim of this investigation was to define and assess Salbutamol sulphate and Theophylline framework tablets, prolonged discharge dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD).
Anil Kumar, Naveen Goyal
semanticscholar +3 more sources
The Role of Ginseng as an Anti-Asthmatic Agent
Acupuncture and Herbal MedicineGinseng is one of the most commonly used herbal medicines in Asia owing to its anti-inflammatory, cognitive, and immune effects. Many of these properties can be attributed to the ginsenosides, major pharmacological agents of ginseng.
Kailynn J. Yang +3 more
semanticscholar +3 more sources
European Journal of Medicinal Chemistry, 2017 A series of novel α-terpineol derivatives were designed and synthesized through structural derivatization of the tertiary hydroxyl moiety or reduction of the double bond. Of the resulting compounds, eight compounds enhanced relaxation of airway smooth muscle (ASM) compared to the α-terpineol precursor, and four compounds (4a, 4d, 4e, and 4i)were ...
Wanping Zhu +4 more
semanticscholar +6 more sources
Asian Journal of Pharmaceutical and Clinical Research, 2018 Objective: Adverse drug reactions (ADRs) are well known to occur with any class of drugs when used in normal doses for the management of diseases. The main aim of the study was to detect and analyze ADRs in patients with bronchial asthma in a Coimbatore ...
A. Muthukumar, Sundara Ganapathy R
semanticscholar +4 more sources
Mycophenolate Mofetil, an Inhibitor of Inosine Monophosphate Dehydrogenase, and Tofacitinib, a Janus Kinase Inhibitor, Attenuate Airway Inflammation and Hyperresponsiveness in a Mouse Model of Allergic Asthma [PDF]
MoleculesTreatment-resistant asthma remains an unresolved clinical problem and a challenge for current medical science. Consequently, there is a growing and urgent need to develop novel or alternative therapeutic options for the treatment of asthma.
Bernard Kravčenia, Tomasz Maślanka
doaj +2 more sources
Antagonism of the Human Thromboxane A2 Receptor by an Anti-asthmatic Agent AA-2414.
Biological and Pharmaceutical Bulletin, 1994 The human thromboxane A2 receptor (TXA2-R)-coding gene was introduced into Chinese hamster ovary cells and a cell line (TCHO-25) stably expressing TXA2-R, at a level of 3 x 10(5)/cell, was obtained. An anti-asthmatic agent AA-2414 [(+-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7- phenylheptanoic acid] competitively inhibited the specific binding of a ...
T Kurokawa +4 more
openalex +5 more sources
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2021 Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders.
Ali Parlar +11 more
openalex +4 more sources