Results 1 to 10 of about 32,098 (325)

Antagonism of the Human Thromboxane A2 Receptor by an Anti-asthmatic Agent AA-2414.

Biological and Pharmaceutical Bulletin, 1994
The human thromboxane A2 receptor (TXA2-R)-coding gene was introduced into Chinese hamster ovary cells and a cell line (TCHO-25) stably expressing TXA2-R, at a level of 3 x 10(5)/cell, was obtained. An anti-asthmatic agent AA-2414 [(+-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7- phenylheptanoic acid] competitively inhibited the specific binding of a ...
T Kurokawa, Takashi Matsumoto, Yuzuru Ashida, Reiko Sasada, Satoru Iwasa   +4 more
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Research on and developmental strategy of anti-asthmatic agents

Folia Pharmacologica Japonica, 2008
気管支喘息の基本となる病態が気道の慢性炎症であることから，吸入ステロイド薬を中心とした抗炎症療法の導入は喘息症状のコントロールを可能にし，喘息患者のquality of lifeを飛躍的に向上させた．その一方で，分子レベルでの病態への理解が深まり，特に気道炎症の発症・進展に関わる過程と関連する各種因子の解明が進むことで，より安全で効果的な治療薬の創製に向けた研究開発が試みられている．本稿では，気道炎症の制御を作用メカニズムとした新規喘息治療薬に焦点をあて，その概略を紹介する．
Ryuichi Totsuka, M. Kikuchi
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A Pharmacovigilance Study on Anti-Asthmatic Agent

International Journal for Research in Applied Science and Engineering Technology
Pharmacovigilance plays a critical role in ensuring the safety and efficacy of anti-asthmatic agents, including inhaled corticosteroids (ICS), long-acting beta-agonists (LABAs), and leukotriene receptor antagonists (LTRAs). This study evaluates adverse drug reactions (ADRs) associated with these medications, emphasizing their clinical impact, risk ...
Sandip Mande
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An Efficient Synthesis of the Anti-asthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.

Chemical and Pharmaceutical Bulletin, 2000
6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin- 4-yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti-asthmatic agent based on selective phosphodiesterase 4 inhibition. It was necessary for the further evaluation of 1 to develop an efficient synthetic route for 1, especially the construction of the 1-(2-methoxyethyl)-2-pyridone ...
M. Sugahara, Yuki Moritani, Takeshi Kuroda, K Kondo, Hideshi Shimadzu, T. UKITA   +5 more
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IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS

International Journal of Pharmaceutical Sciences and Drug Research, 2018
Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. The prevalence of asthma varies widely in different regions of the world due to distinct genetic, environmental and occupational risk factors.
Shashank Shekhar Mishra, Neeraj Kumar, Hamendra Pratap Singh, Shashi Ranjan, Chandra Shekhar Sharma   +4 more
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Pharmacological profiles of F-1322, a novel anti-asthmatic agent. (1). Mechanisms of action.

Folia Pharmacologica Japonica, 1995
The pharmacological effects of N-[2-(4-(benzhydryloxy)piperidino)ethyl]-3-hydroxy-5-(3-pyridyl methoxy)-2- naphthamide (F-1322), a novel anti-asthmatic agent, was investigated in vitro. The results obtained were as follows: 1) In the isolated trachea of guinea pigs, F-1322 showed a markedly potent antagonistic action against the contraction induced by ...
Bunsho Lee, K Takasaki, Akinori Mochizuki, Norihiko Tamura, Y Higashide, Tetsuaki Yamaura   +5 more
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Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent

Bioorganic & Medicinal Chemistry, 2006
The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route.
Edward C. Lawson, Rosemary J. Santulli, Alexey B. Dyatkin, Scott Ballentine, William M. Abraham, Sandra Rudman, Clive Page, Lawrence de Garavilla, Bruce P. Damiano, William A. Kinney, Bruce E. Maryanoff   +10 more
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Resveratrol as an anti-asthmatic agent: could this stilbenoid help against COVID-19 in any way? A meta-analysis

Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2021
Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders.
Ali Parlar, Amner Muñoz-Acevedo, Fatih Üçkardeş, Luisauris Jaimes, Ina Aneva, Bernardo Morales, Amina Unis, Maité Rodríguez-Díaz, Önder Yumrutaş, Raúl Vinet, Simona Bungău, José Luís Martínez   +11 more
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Anti-asthmatic Agent [PDF]

, 2020
National Cancer Institute
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Design, Development and Evaluation of Extended Release Tablets of Anti-asthmatic Agents using various Polymers

International Journal of Research and Development in Pharmacy & Life Sciences, 2018
The aim of this investigation was to define and assess Salbutamol sulphate and Theophylline framework tablets, prolonged discharge dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Powder blends of the drugs (Salbutamol sulphate and Theophylline) and polymers (HPMC K100M and Xanthan Gum) were evaluated for loose bulk ...
Anil Kumar, Naveen Goyal
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