Results 1 to 10 of about 74,311 (234)
Mycophenolate Mofetil, an Inhibitor of Inosine Monophosphate Dehydrogenase, and Tofacitinib, a Janus Kinase Inhibitor, Attenuate Airway Inflammation and Hyperresponsiveness in a Mouse Model of Allergic Asthma [PDF]
MoleculesTreatment-resistant asthma remains an unresolved clinical problem and a challenge for current medical science. Consequently, there is a growing and urgent need to develop novel or alternative therapeutic options for the treatment of asthma.
Bernard Kravčenia, Tomasz Maślanka
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Antagonism of the Human Thromboxane A2 Receptor by an Anti-asthmatic Agent AA-2414.
Biological and Pharmaceutical Bulletin, 1994 The human thromboxane A2 receptor (TXA2-R)-coding gene was introduced into Chinese hamster ovary cells and a cell line (TCHO-25) stably expressing TXA2-R, at a level of 3 x 10(5)/cell, was obtained. An anti-asthmatic agent AA-2414 [(+-)-7-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-7- phenylheptanoic acid] competitively inhibited the specific binding of a ...
Susumu Iwasa +4 more
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Research on and developmental strategy of anti-asthmatic agents
Folia Pharmacologica Japonica, 2008 気管支喘息の基本となる病態が気道の慢性炎症であることから，吸入ステロイド薬を中心とした抗炎症療法の導入は喘息症状のコントロールを可能にし，喘息患者のquality of lifeを飛躍的に向上させた．その一方で，分子レベルでの病態への理解が深まり，特に気道炎症の発症・進展に関わる過程と関連する各種因子の解明が進むことで，より安全で効果的な治療薬の創製に向けた研究開発が試みられている．本稿では，気道炎症の制御を作用メカニズムとした新規喘息治療薬に焦点をあて，その概略を紹介する．
Matsuo Kikuchi, Ryuichi Totsuka
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Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2021 Resveratrol is a phenolic phytoconstituent found in many plants. This molecule has always caught the attention of scientists because of biological potentials such as inhibition of inflammation, oxidative stress and platelet aggregation as well as to prevent/protect against cardiovascular and neurodegenerative disease/disorders.
Ali Parlar +11 more
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A Pharmacovigilance Study on Anti-Asthmatic Agent
International Journal for Research in Applied Science and Engineering TechnologyPharmacovigilance plays a critical role in ensuring the safety and efficacy of anti-asthmatic agents, including inhaled corticosteroids (ICS), long-acting beta-agonists (LABAs), and leukotriene receptor antagonists (LTRAs). This study evaluates adverse drug reactions (ADRs) associated with these medications, emphasizing their clinical impact, risk ...
Sandip Mande
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IN SILICO PHARMACOKINETIC, BIOACTIVITY AND TOXICITY STUDY OF SOME SELECTED ANTI-ASTHMATIC AGENTS
International Journal of Pharmaceutical Sciences and Drug Research, 2018 Asthma is a disease affecting the airways that carry air to and from lungs. Exposure to various irritants and substances that trigger allergies (allergens) can trigger signs and symptoms of asthma. The prevalence of asthma varies widely in different regions of the world due to distinct genetic, environmental and occupational risk factors.
Neeraj Kumar +4 more
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Journal of Drug Delivery and Therapeutics, 2013 The objective of the present study was to develop matrix tablets of salbutmol sulphate sustained release dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Compatibility study was performed through Fourier Transformer Infrared spectroscopy revealed that there no interaction between drug and polymers.
Nityanand S. Zadbuke +5 more
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An Efficient Synthesis of the Anti-asthmatic Agent T-440: A Selective N-Alkylation of 2-Pyridone.
Chemical and Pharmaceutical Bulletin, 2000 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Masakatsu Sugahara +5 more
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International Journal of Research and Development in Pharmacy & Life Sciences, 2018 The aim of this investigation was to define and assess Salbutamol sulphate and Theophylline framework tablets, prolonged discharge dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). Powder blends of the drugs (Salbutamol sulphate and Theophylline) and polymers (HPMC K100M and Xanthan Gum) were evaluated for loose bulk ...
Anil Kumar, Naveen Goyal
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Pharmacological profiles of F-1322, a novel anti-asthmatic agent. (1). Mechanisms of action.
Folia Pharmacologica Japonica, 1995 The pharmacological effects of N-[2-(4-(benzhydryloxy)piperidino)ethyl]-3-hydroxy-5-(3-pyridyl methoxy)-2- naphthamide (F-1322), a novel anti-asthmatic agent, was investigated in vitro. The results obtained were as follows: 1) In the isolated trachea of guinea pigs, F-1322 showed a markedly potent antagonistic action against the contraction induced by ...
Yasushi Higashide +5 more
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