Results 41 to 50 of about 809 (171)

Are rheumatoid factor, anti-citrullinated, and anti-carbamylated protein antibodies linked by post-translational modification of IgG? [PDF]

, 2016
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Accepted manuscript online: 2 August 2016No abstract is available.Support for this project was provided by the Cornwall Arthritis ...
Abedi-Valugerdi, Aho, Brink, Clavarino, Jin, Koppejan, Koro, Ling, Lugli, Rangel-Moreno, Tarcsa, Wang   +11 more
core   +1 more source

Clinical and etiological meaning of anti-carbamylated protein antibodies in rheumatoid arthritis

Immunological Medicine, 2019
Several autoantibodies against proteins with post-translational modifications have been detected in patients with rheumatoid arthritis (RA) and are called anti-modified protein antibodies (AMPAs).
Shuichiro Nakabo
doaj   +1 more source

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Arthritis Research & Therapy, 2017
Background Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have
Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw   +4 more
doaj   +1 more source

Serum rheumatoid factor IgA, anti-citrullinated peptide antibodies with secretory components, and anti-carbamylated protein antibodies associate with interstitial lung disease in rheumatoid arthritis

BMC Musculoskeletal Disorders, 2022
Objective Rheumatoid arthritis (RA) is often complicated with chronic lung diseases (CLD), including interstitial lung disease (ILD) and airway disease, which occur as extra-articular manifestations.
Shomi Oka, Takashi Higuchi, Hiroshi Furukawa, Kota Shimada, Akira Okamoto, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita, Shigeto Tohma   +13 more
doaj   +1 more source

Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se:a multicenter cohort study [PDF]

, 2016
BACKGROUND: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA).
Ajeganova, Sofia, Division of Musculoskeletal & Dermatological Sciences (L5), Hafström, Ingiäld, Huizinga, Tom W J, Humphreys, Jennifer, Karolinska Institutet, Karolinska University Hospital, Kyoto University, Leiden University, Leiden University Medical Center, Lund University, MacGregor, Alex J, Matsuda, Fumihiko, Mimori, Tsuneyo, Muhammad, Ammar, Svensson, Björn, Symmons, Deborah, Terao, Chikashi, Toes, René E M, Trouw, Leendert A, University of East Anglia, van der Helm-van Mil, Annette H M, Van Der Woude, Diane, van Wesemael, Tineke J, Verstappen, Suzanne   +24 more
core   +1 more source

Different Hierarchies of Anti–Modified Protein Autoantibody Reactivities in Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 72, Issue 10, Page 1643-1657, October 2020., 2020
Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of seropositive rheumatoid arthritis (RA). Yet, the precise disease‐relevant autoantigens that are targeted by ACPAs remains a matter of debate. This study utilized patient‐derived monoclonal ACPAs, rather than serum autoantibody analysis, to characterize the multireactivity to ...
Peter Sahlström, Monika Hansson, Johanna Steen, Khaled Amara, Philip J. Titcombe, Björn Forsström, Ragnhild Stålesen, Lena Israelsson, Luca Piccoli, Karin Lundberg, Lars Klareskog, Daniel L. Mueller, Anca I. Catrina, Karl Skriner, Vivianne Malmström, Caroline Grönwall   +15 more
wiley   +1 more source

Carbamylation reduces the capacity of IgG for hexamerization and complement activation

Clinical &Experimental Immunology, Volume 200, Issue 1, Page 1-11, April 2020., 2020
Carbamylation of both monomeric IgG and pre‐formed hexameric IgG greatly impaired the capacity to trigger complement activation. Upon carbamylation the pre‐formed hexameric IgG, dissociated into monomeric IgG in solution. Indicating that carbamylation does not only influence C1q binding, but also the ability to form hexamers. Summary Carbamylation is a
R. Lubbers, S. C. Oostindie, D. J. Dijkstra, P. W. H. I. Parren, M. K. Verheul, L. Abendstein, T. H. Sharp, A. de Ru, G. M. C. Janssen, P. A. van Veelen, E. T. J. van den Bremer, B. Bleijlevens, B.‐J. de Kreuk, F. J. Beurskens, L. A. Trouw   +14 more
wiley   +1 more source

Anti-carbamylated protein antibodies and skin involvement in patients with systemic sclerosis: An intriguing association.

PLoS ONE, 2018
Carbamylation is a post-translational modification that mostly affects proteins with low turnover, such as dermal proteins. Carbamylated proteins accumulate in skin in an age-dependent manner, contributing to tissue alterations.
Elvira Favoino, Marcella Prete, Serena Vettori, Addolorata Corrado, Francesco Paolo Cantatore, Gabriele Valentini, Federico Perosa   +6 more
doaj   +1 more source

Utility of anti-carbamylated protein antibodies in the diagnosis of early rheumatoid arthritis

Indian Journal of Rheumatology, 2019
Background: Anti-carbamylated protein (anti-CarP) antibodies are present in patients with Rheumatoid arthritis (RA) and may present before disease onset.
Ashraf H Mohamed, Asmaa Enein, Noha Abdelsalam, Mona Balata, Sameh Abdellatif, Ehsan Rizk, Ahmed Fathy   +6 more
doaj   +1 more source

Autoantibodies in inflammatory arthritis [PDF]

, 2016
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease characterized by extensive synovitis resulting in erosions of articular cartilage and marginal bone with joint destruction.
Chimenti, Ms, Conigliaro, P, Novelli, L, Perricone, C, Perricone, R, Sunzini, F, Triggianese, P   +6 more
core   +1 more source